Intra-arterial induction high-dose chemotherapy with cisplatin for oral and oropharyngeal cancer: long-term results

Intra-arterial (IA) chemotherapy for curative treatment of head and neck cancer experienced a revival in the last decade. Mainly, it was used in concurrent combination with radiation in organ-preserving settings. The modern method of transfemoral approach for catheterisation, superselective perfusion of the tumour-feeding vessel, and high-dose (150 mg m−2) administration of cisplatin with parallel systemic neutralisation with sodium thiosulphate (9 g m−2) made preoperative usage feasible. The present paper presents the results of a pilot study on a population of 52 patients with resectable stage 1–4 carcinomas of the oral cavity and the oropharynx, who were treated with one cycle of preoperative IA chemotherapy executed as mentioned above and radical surgery. There have been no interventional complications of IA chemotherapy, and acute side effects have been low. One tracheotomy had to be carried out due to swelling. The overall clinical local response has been 69%. There was no interference with surgery, which was carried out 3–4 weeks later. Pathological complete remission was assessed in 25%. The mean observation time was 3 years. A 3-year overall and disease-free survival was 82 and 69%, respectively, and at 5 years 77 and 59%, respectively. Survival results were compared to a treatment-dependent prognosis index for the same population. As a conclusion, it can be stated that IA high-dose chemotherapy with cisplatin and systemic neutralisation in a neoadjuvant setting should be considered a feasible, safe, and effective treatment modality for resectable oral and oropharyngeal cancer. The low toxicity of this local chemotherapy recommends usage especially in stage 1–2 patients. The potential of survival benefit as indicated by the comparison to the prognosis index should be controlled in a randomised study

The impact of siblings during talent development: A longitudinal examination in sport

Recent studies have begun to explore the potentially positive impact of siblings on sporting talent development. This study aimed to explore potential mechanisms through which siblings impact on this process. Bi-monthly interviews were conducted with four families over a 1 year period (parents and siblings; N = 14) during the talent development process. Findings revealed several themes (regularity of interaction, emotional interpersonal skills, rivalry, resilience, and separation) aligning with previous studies, alongside two new themes; communication and skill development. The study’s longitudinal nature exposed important differences of potential mechanisms across families, highlighting the complex nature of the sibling relationship

The Role of Husbands’ and Wives’ Emotional Expressivity in the Marital Relationship

The current investigation was designed to examine the role of positive and negative emotional expressivity in the marital relationship. Data from 58 married couples were used to assess spouses’ levels of emotional expressivity and how these levels predicted reports of marital functioning. Regression analyses indicated that positive emotional expressivity had limited influence on marital functioning. Negative expressivity, however, had a strong impact on marital love, conflict, and ambivalence. Post-hoc analyses revealed significant differences between pairings in which the husband was high in negative expressivity, irrespective of wives’ negative emotional expressivity, and pairings in which both partners were low in negative emotional expressivity. These findings are discussed with respect to previous research that suggests that wives’ emotional expressivity is the major determinant of marital functioning.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45641/1/11199_2005_Article_3726.pd

Brothers and sisters in China: no longer the one-child family

Following the end of the one-child-policy in China in 2016 and the gradual relaxation of only-one child per family in selected areas prior to that, family composition and relationship dynamics, especially siblings relationship within the Chinese familial context has gone through a rapid growth and some significant changes as a result of the introduction of the two-child policy. This policy change, with the possibility of adding another child into the family may have profound implications on the family system, its functioning and care relations among those living in China (Chen in The second child: Family transition and adjustment. Shanghai Educational Publishing House, Shanghai, China, 2018). First, this chapter considers the existing studies related to Chinese familial culture within the context of its population policy that has dominated family life in China in the past three decades. This chapter will then review empirical findings on role of Chinese parents in the development of sibling's relationships such as sibling conflict and social comparison; how their co-parenting behaviour and personal siblings experience may hinder or promote better siblings' relations. The chapter will also draw on existing research findings on the adaptation and adjustments of Chinese firstborn children during this transition into siblinghood. Finally, the chapter summarises and discusses the unique characteristics of sibling relationships within the Chinese context and its implication for family dynamics and the development of the new generation in China. Themes for future investigation are also suggested

Anxiety as a cause of attachment avoidance in women with Turner Syndrome

Working models of attachment are internal depictions of self relative to others and have been described in terms of two dimensions: (1) attachment avoidance and (2) attachment anxiety. An exploratory qualitative study was carried out to build understandings about women with Turner Syndrome (TS) and the psychosocial impact their infertility has upon salient relationships. In one-to-one semi-structured interviews, five women with TS were asked: How do you perceive your womanhood and infertility status has affected your relationships with: (1) the opposite sex, (2) siblings and (3) peers? In opposite-sex relationships, infertility status was found to arouse fear of ending up alone and anxiety over engaging in romantic relationships. In sibling relationships, jealousy was expressed in relation to disparity with sister(s) more natural maturation to womanhood, and, within peer relationships, consequences from divulging infertility status created attachment avoidance with friends. Further investigation in this area is merited