The Analysis of Evolutionary Changes in the System of Higher Medical Education in Ukraine in the First Half of the Xx-th Century

The article is devoted to the development of the higher medical education in Ukraine in 1900–1940. The actuality of the history of educational establishments\u27 system generalization for the theoretical understanding of educational process peculiarities within a certain brunch of education is revealed. The state of the higher medical education in Ukraine at the beginning of the XX century is depicted. The development of universities\u27 medical departments in the first two decades of the XX century is analyzed. The common features and differences of university education in Russian and Austrian parts of Ukraine are described. Organizational forms of medical educational establishments are analyzed. The tendency of increasing the system of educational establishments by the foundation of the higher courses for women is stated. The changes in the system of medical education after the establishment of the soviet power in Ukraine are analyzed. Soviet government activities in the sphere of higher education in general and its medical branch in particular are depicted. The dynamics of medical institutes as well as the system of higher education administration development in 1920–1930-s is revealed. New organizational forms were established that reflected the search for the optimal educational system corresponding to the new epoch challenges and the goals of the new state. The influence of ideological conceptions on all branches of higher education in that time is obvious. It was especially strong in 1920-s in comparison with more pragmatic 1930-s. The general conclusion is made about the unification and strengthening of the state control in the educational process, especially in the soviet period. It is stated that, though the organs of self-administration in higher school were functioning, the educational process was to the great extent centralized. The formation of the soviet higher medical education system in Ukraine in general till the end of 1930-s is noted

The University Digital Library as a Center for Increasing the Digital Competences of Students

This paper aims to outline the advantages of increasing the quality of education at the University by describing some important organizational approaches and methodological guidelines for the development of digital competences among students. The study focuses on the level of digital (library) competencies among students and their need to use scientific information sources in the University Library. A survey was conducted using the direct individual inquiry method through a pre-designed questionnaire comprising 20 questions. The statistical apparatus includes statistical methods - frequency, mean value and confidence level – 95 %. The survey results suggest that in today's digital society it is particularly important for the Library to become an information-communicative center for improving the students' skills by using the rich collection of information and digital resources and increasing the quality of education and training at the University. The presented study seeks to offer new approaches and ways to motivate students toward effective use of digital information and of new tools for working in the digital environment

Substantiation Of Hot Smoking Parameters Based On Sensory Researches In Hot Fish Marinades Technology In The Jelly Pouring

Modern technologies of food products provide creation of healthy, tasty and safe products, characterized by high organoleptic properties, balance by main food factors and structural-mechanical parameters of a product.The main technological process in the technology of fish marinades and a jelly pouring is the hot smoking. Technological parameters of the hot smoking have been scientifically grounded on the base of the statistical processing of data of sensory studies. Organoleptic assessment of semi-products after the thermal processing was carried out by 5-point system corresponding to the elaborated scale. The quantitative assessment of organoleptic parameters of the quality of experimental samples was determined by the totality of all assessment points, taking into account chosen weight coefficients depending on the importance degree of a given parameter at forming consumer qualities of a product. The generalizing quality parameter was calculated as a sum of assessments of organoleptic parameters – taste, consistence and appearance. Individual assessments of separated quality parameters of products (in points) were put in degustation lists and statistically processed by the averaging method.The smoking process realization, according to scientifically grounded parameters allows to produce the new type of tasty, healthy and presentable culinary products of a perspective object of Ukrainian aquaculture – silver carp of a prolonged storage term

Mathematical Development Program for Calculation of Fatty Acid Composition Blend of Vegetable Oils

The method of solution of the problem of polyunsaturated fatty acids (PUFA) lack in milk products is offered in the work. It is offered to create the milk-containing products (sour cream product) with adjusted fatty acid composition. The possibility of replacement of the mass part of milk fat (50 %) by the blend of natural vegetable oils was studied. For the solution of this problem the program within MatLab mathematical package was elaborated. The recommended fatty acids (FA) ratio [3] is selected as optimization parameter. The optimized blend was created using the elaborated program. The data, received by mathematical calculations, were experimentally proved using the method of gas-liquid chromatography [7]. On the based of the results, received at the studies, it can be stated, that 50 % replacement of mass part of fat (m.p.f.) in milk products (sour cream product) by elaborated blend, allows partially adjust its FA composition

The Long and Viscous Road: Uncovering Nuclear Diffusion Barriers in Closed Mitosis

During Saccharomyces cerevisiae closed mitosis, parental identity is sustained by the asymmetric segregation of ageing factors. Such asymmetry has been hypothesized to occur via diffusion barriers, constraining protein lateral exchange in cellular membranes. Diffusion barriers have been extensively studied in the plasma membrane, but their identity and organization within the nucleus remain unknown. Here, we propose how sphingolipid domains, protein rings, and morphological changes of the nucleus may coordinate to restrict protein exchange between nuclear lobes. Our spatial stochastic model is based on several lines of experimental evidence and predicts that, while a sphingolipid domain and a protein ring could constitute the barrier during early anaphase; a sphingolipid domain spanning the bridge between lobes during late anaphase would be entirely sufficient. Additionally, we explore the structural organization of plausible diffusion barriers. Our work shows how nuclear diffusion barriers in closed mitosis may be emergent properties of simple nanoscale biophysical interactions.Comment: 21 pages, 6 figures and supplementary material (including 8 additional figures and a Table

A Selection Criterion for Patterns in Reaction-Diffusion Systems

Alan Turing's work in Morphogenesis has received wide attention during the past 60 years. The central idea behind his theory is that two chemically interacting diffusible substances are able to generate stable spatial patterns, provided certain conditions are met. Turing's proposal has already been confirmed as a pattern formation mechanism in several chemical and biological systems and, due to their wide applicability, there is a great deal of interest in deciphering how to generate specific patterns under controlled conditions. However, techniques allowing one to predict what kind of spatial structure will emerge from Turing systems, as well as generalized reaction-diffusion systems, remain unknown. Here, we consider a generalized reaction diffusion system on a planar domain and provide an analytic criterion to determine whether spots or stripes will be formed. It is motivated by the existence of an associated energy function that allows bringing in the intuition provided by phase transitions phenomena. This criterion is proved rigorously in some situations, generalizing well known results for the scalar equation where the pattern selection process can be understood in terms of a potential. In more complex settings it is investigated numerically. Our criterion can be applied to efficiently design Biotechnology and Developmental Biology experiments, or simplify the analysis of hypothesized morphogenetic models.Comment: 19 pages, 10 figure

The Analysis of Indices of Cerebral Blood Circulation in Women-smokers

The results of rheoencephalography of female smokers 17–21 years old and control group were studied and analyzed. The aim of this work was to explain and analyze physiological features of smoking effect on functional changes of regional hemodynamics in smoking women.The study of cerebral hemodynamics was carried out by the method of rheoencephalography (REG) – automated system of complex examination “Askold”, intended for automation of medical tasks processing with input of information in “online” regime (insertion of data directly from examined person). The recording of rheogram was carried out in front-mastoid branches that allowed register REG separately in both hemispheres of brain and determine the main amplitude-temporal characteristics of cerebral blood circulation and changes of vascular tone.Analyzing the main indices of regional hemodynamics in female smokers, the statistically lower values of time of rheowave delay (Ra) were noted. There was also revealed a decrease of volumetric cerebral blood circulation and increase of resistant arteries tone. There were fixed the moderate asymmetry (from 15 to 25 %) of blood filling in vertebral-basilar vascular basin (basin of spinal and internal carotid arteries) and the signs of complicated venous outflow in both hemispheres.Such changes of indices indicate the decrease of volumetric blood circulation of cerebral hemodynamics, striking volume of blood and increase of tone of distribution arteries that testify to the decrease of blood circulation in main vessels, and also smoking is a cause of hypoxia (oxygen deprivation) of cerebral cells as a result of decrease of blood inflow. In the women of control group all indices are within norm that testifies to the normal course of physiological processes in organism

Order Reduction of the Chemical Master Equation via Balanced Realisation

We consider a Markov process in continuous time with a finite number of discrete states. The time-dependent probabilities of being in any state of the Markov chain are governed by a set of ordinary differential equations, whose dimension might be large even for trivial systems. Here, we derive a reduced ODE set that accurately approximates the probabilities of subspaces of interest with a known error bound. Our methodology is based on model reduction by balanced truncation and can be considerably more computationally efficient than the Finite State Projection Algorithm (FSP) when used for obtaining transient responses. We show the applicability of our method by analysing stochastic chemical reactions. First, we obtain a reduced order model for the infinitesimal generator of a Markov chain that models a reversible, monomolecular reaction. In such an example, we obtain an approximation of the output of a model with 301 states by a reduced model with 10 states. Later, we obtain a reduced order model for a catalytic conversion of substrate to a product; and compare its dynamics with a stochastic Michaelis-Menten representation. For this example, we highlight the savings on the computational load obtained by means of the reduced-order model. Finally, we revisit the substrate catalytic conversion by obtaining a lower-order model that approximates the probability of having predefined ranges of product molecules.Comment: 12 pages, 6 figure