How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome

Thrombotic thrombocytopenic purpura (TTP) and atypical haemolytic uraemic syndrome (aHUS) are acute, rare life-threatening thrombotic microangiopathies that require rapid diagnosis and treatment. They are defined by microangiopathic haemolytic anaemia and thrombocytopenia, with renal involvement primarily in aHUS and neurological and cardiological sequelae in TTP. Prompt treatment for most cases of both conditions is with plasma exchange initially and monoclonal therapy (rituximab in TTP and eculizumab in aHUS) as the mainstay of therapy. Here we discuss the diagnosis and therapy for both disorders

A dynamic scheme for generating number squeezing in Bose-Einstein condensates through nonlinear interactions

We develop a scheme to generate number squeezing in a Bose-Einstein condensate by utilizing interference between two hyperfine levels and nonlinear atomic interactions. We describe the scheme using a multimode quantum field model and find agreement with a simple analytic model in certain regimes. We demonstrate that the scheme gives strong squeezing for realistic choices of parameters and atomic species. The number squeezing can result in noise well below the quantum limit, even if the initial noise on the system is classical and much greater than that of a poisson distribution.Comment: 4 pages, 3 figure

Corrected Table for the Parametric Coefficients for the Optical Depth of the Universe to Gamma-rays at Various Redshifts

Table 1 in our paper, ApJ 648, 774 (2006) entitled "Intergalactic Photon Spectra from the Far IR to the UV Lyman Limit for 0 < z < 6 and the Optical Depth of the Universe to High Energy Gamma-Rays" had erroneous numbers for the coefficients fitting the parametric form for the optical depth of the universe to gamma-rays. The correct values for these parameters as described in the original text are given here in a corrected table for various redshifts for the baseline model (upper row) and fast evolution (lower row) for each individual redshift. The parametric approximation is good for optical depths between 0.01 and 100 and for gamma-ray energies up to ~2 TeV for all redshifts but also for energies up to ~10 TeV for redshifts less than 1.Comment: Table 1 corrected and new gamma-ray energy range of validity give

An Empirical Determination of the Intergalactic Background Light from UV to FIR Wavelengths Using FIR Deep Galaxy Surveys and the Gamma-ray Opacity of the Universe

We have previously calculated the intergalactic background light (IBL) as a function of redshift in the far ultraviolet to near infrared range, based purely on data from deep galaxy surveys. Here we utilize similar methods to determine the mid- and far infrared IBL out to a wavelength of 850 microns. Our approach enables us to constrain the range of photon densities, based on the uncertainties from observationally determined luminosity densities and colors. By also including the effect of the 2.7 K cosmic background photons, we determine 68% confidence upper and lower limits on the opacity of the universe to gamma-rays up to PeV energies. Our direct results on the IBL are consistent with those from complimentary gamma-ray analyses using observations from the Fermi $\gamma$-ray space telescope and the H.E.S.S. air Cherenkov telescope. Thus, we find no evidence of previously suggested processes for the modification of gamma-ray spectra other than that of absorption by pair production alone.Comment: 33 pages, 11 figures, replacement matches article published in ApJ 827:6 (2016

Collapsible reflector Patent

Self erecting parabolic reflector design for use in spac

An Empirical Determination of the Intergalactic Background Light Using NIR Deep Galaxy Survey Data out to 5 microns and the Gamma-ray Opacity of the Universe

We extend our previous model-independent determination of the intergalactic background light (IBL), based purely on galaxy survey data, out to a wavelength of 5 microns. Our approach enables us to constrain the range of photon densities, based on the uncertainties from observationally determined luminosity densities and colors. We further determine a 68% confidence upper and lower limit on the opacity of the universe to gamma-rays up to energies of 1.6/(1+z) TeV. A comparison of our lower limit redshift-dependent opacity curves to the opacity limits derived from the results of both ground-based air Cherenkov telescope and Fermi-LAT observations of PKS 1424+240 allows us to place a new upper limit on the redshift of this source, independent of IBL modeling.Comment: version accepted for publication in the Astrophysical Journal, 23 pages, 4 figure

Lorentz Invariance Violation and the Observed Spectrum of Ultrahigh Energy Cosmic Rays

There has been much interest in possible violations of Lorentz invariance, particularly motivated by quantum gravity theories. It has been suggested that a small amount of Lorentz invariance violation (LIV) could turn off photomeson interactions of ultrahigh energy cosmic rays (UHECRs) with photons of the cosmic background radiation and thereby eliminate the resulting sharp steepening in the spectrum of the highest energy CRs predicted by Greisen Zatsepin and Kuzmin (GZK). Recent measurements of the UHECR spectrum reported by the HiRes and Auger collaborations, however, indicate the presence of the GZK effect. We present the results of a detailed calculation of the modification of the UHECR spectrum caused by LIV using the formalism of Coleman and Glashow. We then compare these results with the experimental UHECR data from Auger and HiRes. Based on these data, we find a best fit amount of LIV of $4.5^{+1.5}_{-4.5} \times 10^{-23}$,consistent with an upper limit of $6 \times 10^{-23}$. This possible amount of LIV can lead to a recovery of the cosmic ray spectrum at higher energies than presently observed. Such an LIV recovery effect can be tested observationally using future detectors.Comment: corrected proof version to be published in Astroparticle Physic

Is the Universe More Transparent to Gamma Rays Than Previously Thought?

The MAGIC collaboration has recently reported the detection of the strong gamma-ray blazar 3C279 during a 1-2 day flare. They have used their spectral observations to draw conclusions regarding upper limits on the opacity of the Universe to high energy gamma-rays and, by implication, upper limits on the extragalactic mid-infrared background radiation. In this paper we examine the effect of gamma-ray absorption by the extragalactic infrared radiation on intrinsic spectra for this blazar and compare our results with the observational data on 3C279. We find agreement with our previous results, contrary to the recent assertion of the MAGIC group that the Universe is more transparent to \gray s than our calculations indicate. Our analysis indicates that in the energy range between ~80 and ~500 GeV, 3C279 has a best-fit intrinsic spectrum with a spectral index ~1.78 using our fast evolution model and ~2.19 using our baseline model. However, we also find that spectral indices in the range of 0.0 to 3.0 are almost as equally acceptable as the best fit spectral indices. Assuming the same intrinsic spectral index for this flare as for the 1991 flare from 3C279 observed by EGRET, viz., 2.02, which lies between our best fit indices, we estimate that the MAGIC flare was ~3 times brighter than the EGRET flare observed 15 years earlier.Comment: version accepted for publication in ApJ Letter

On the spectrum of Ultrahigh Energy Cosmic Rays and the Gamma Ray Burst Origin Hypothesis

It has been suggested that cosmological gamma-ray bursts (GRBs) can produce the observed flux of cosmic rays at the highest energies. However, recent studies of GRBs indicate that their redshift distribution likely follows that of the average star formation rate and that GRBs were more numerous at high redshifts. As a consequence, we show that photomeson production energy losses suffered by ultrahigh energy cosmic rays coming from GRBs would produce too sharp a spectral high energy cutoff to be consistent with the air shower data. Furthermore, we show that cosmological GRBs fail to supply the energy input required to account for the cosmic ray flux above 10 EeV by a factor of 100-1000.Comment: final version with minor changes, Astroparticle Physics, in pres