XR Technology Deployment in Value Creation

With increasing computing power and data transmission performance of information technologies, the application scenarios for Extended Reality (XR) technologies in industries are growing. Despite the ongoing scientific investigation of industrial XR applications for over 25 years, these technologies are still considered emerging. Within this paper, we present an industry- and business-process agnostic approach for classifying the deployment purposes of XR technologies in value creation. We identified two major research streams regarding the role of XR technologies in value creation: (1) the research initiatives focusing on business-process-specific use case analysis and (2) industry-oriented research reviews. This results in limited identification of suitable application scenarios for new use cases and restricted transferability of the existing use case to future deployments. First, we provide a qualitative analysis of the current research streams. Then, in the second step, by abstracting the XR technology from the existing business processes and the industry-specific context, the generic purposes for XR technologies in value creation are identified and defined. The summary of these deployment purposes results in a taxonomy that enables the identification and transfer of potential use cases of XR technologies in value creation

A Digital One Degree of Freedom Model of an Electromagnetic Position Sensor

The purpose of this project was to improve an existing system currently in use by NASA Langley Research Center (LaRC). The 6-inch Magnetic Suspension and Balance System (MSBS) built at MIT is operational with control in three degrees of freedom, with two additional degrees of freedom exhibiting passive stability. The means for measuring model displacement within the magnetic environment is an Electromagnetic Position Sensor (EPS), consisting of excitation coils at 20 kHz and multiple sets of pickup coils. The pickup coil voltages are proportional to model displacement in each degree of freedom. However, the EPS electronic signal processing system is analog and outdated; setup and adjustment are time consuming. The task was to construct a one degree of freedom model of the EPS including its electronics system in order to explore digital signal processing. The model core is allowed only axial displacement for simplicity; this model coil set is essentially a Linear Variable Differential Transformer (LVDT). The source signal was chosen to be 2.36 kHz for convenience, with scaling up to the full size system at 20 kHz possible. An amplification and filtering circuit board was constructed to modify the signal for the proper functionality of the model EPS. By comparing the reference or excitation coil signal and the measured or pickup coil signal by means of a digital phase measurement method using cross-correlation analysis, the digital algorithm resolves the phase shift between the two signals and their amplitude ratio. The key proof of concept is the digital signal processing algorithm; since the defining characteristics of any signal are the amplitude and phase this algorithm can be adapted to suit various control and setup needs of the MSBS and EPS. By proving that a digital interface with the EPS is possible, the analog interface can be replaced with a digital system

Initial results of a flight investigation of the wing and tail loads on an airplane equipped with a vane-controlled gust-alleviation system

Results are given of an analysis of wing and horizontal-tail spar strains measured on a twin-engine light transport airplane which was modified for the installation of a control system to alleviate airplane motions in turbulent air and thus improve passenger comfort. From a sample of the measurements obtained in flight through clear-air turbulence, normal acceleration at the airplane center of gravity was reduced 43 percent, wing main-spar bending strains were reduced, and wing-spar shear strains were increased. Horizontal-tail shear and bending strains were increased. Measurements of aerodynamic loads obtained in a pull-up with the gust-alleviation system in operation are also presented

Self-forces on extended bodies in electrodynamics

In this paper, we study the bulk motion of a classical extended charge in flat spacetime. A formalism developed by W. G. Dixon is used to determine how the details of such a particle's internal structure influence its equations of motion. We place essentially no restrictions (other than boundedness) on the shape of the charge, and allow for inhomogeneity, internal currents, elasticity, and spin. Even if the angular momentum remains small, many such systems are found to be affected by large self-interaction effects beyond the standard Lorentz-Dirac force. These are particularly significant if the particle's charge density fails to be much greater than its 3-current density (or vice versa) in the center-of-mass frame. Additional terms also arise in the equations of motion if the dipole moment is too large, and when the `center-of-electromagnetic mass' is far from the `center-of-bare mass' (roughly speaking). These conditions are often quite restrictive. General equations of motion were also derived under the assumption that the particle can only interact with the radiative component of its self-field. These are much simpler than the equations derived using the full retarded self-field; as are the conditions required to recover the Lorentz-Dirac equation.Comment: 30 pages; significantly improved presentation; accepted for publication in Phys. Rev.

Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells

Osteosarcoma (OS) is the most common primary malignancy of bone. Mortality is determined by the presence of metastatic disease, but little is known regarding the biochemical events that drive metastases. Two murine OS cell lines, K7M2 and K12, are related but differ significantly in their metastatic potentials: K7M2 is highly metastatic whereas K12 displays much less metastatic potential. Using this experimental system, the mammalian target of rapamycin (mTOR) pathway has been implicated in OS metastasis. We also discovered that aldehyde dehydrogenase (ALDH, a stem cell marker) activity is higher in K7M2 cells than K12 cells. Rapamycin treatment reduces the expression and enzymatic activity of ALDH in K7M2 cells. ALDH inhibition renders these cells more susceptible to apoptotic death when exposed to oxidative stress. Furthermore, rapamycin treatment reduces bone morphogenetic protein-2 (BMP2) and vascular endothelial growth factor (VEGF) gene expression and inhibits K7M2 proliferation, migration, and invasion in vitro. Inhibition of ALDH with disulfiram correlated with decreased mTOR expression and activity. In conclusion, we provide evidence for interaction between mTOR activity, ALDH activity, and metastatic potential in murine OS cells. Our work suggests that mTOR and ALDH are therapeutic targets for the treatment and prevention of OS metastasis. © 2013 Xiaodong Mu et al

Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells

Osteosarcoma (OS) is the most common primary malignancy of bone. Mortality is determined by the presence of metastatic disease, but little is known regarding the biochemical events that drive metastases. Two murine OS cell lines, K7M2 and K12, are related but differ significantly in their metastatic potentials: K7M2 is highly metastatic whereas K12 displays much less metastatic potential. Using this experimental system, the mammalian target of rapamycin (mTOR) pathway has been implicated in OS metastasis. We also discovered that aldehyde dehydrogenase (ALDH, a stem cell marker) activity is higher in K7M2 cells than K12 cells. Rapamycin treatment reduces the expression and enzymatic activity of ALDH in K7M2 cells. ALDH inhibition renders these cells more susceptible to apoptotic death when exposed to oxidative stress. Furthermore, rapamycin treatment reduces bone morphogenetic protein-2 (BMP2) and vascular endothelial growth factor (VEGF) gene expression and inhibits K7M2 proliferation, migration, and invasion in vitro. Inhibition of ALDH with disulfiram correlated with decreased mTOR expression and activity. In conclusion, we provide evidence for interaction between mTOR activity, ALDH activity, and metastatic potential in murine OS cells. Our work suggests that mTOR and ALDH are therapeutic targets for the treatment and prevention of OS metastasis. © 2013 Xiaodong Mu et al

Finite-Dimensional Calculus

We discuss topics related to finite-dimensional calculus in the context of finite-dimensional quantum mechanics. The truncated Heisenberg-Weyl algebra is called a TAA algebra after Tekin, Aydin, and Arik who formulated it in terms of orthofermions. It is shown how to use a matrix approach to implement analytic representations of the Heisenberg-Weyl algebra in univariate and multivariate settings. We provide examples for the univariate case. Krawtchouk polynomials are presented in detail, including a review of Krawtchouk polynomials that illustrates some curious properties of the Heisenberg-Weyl algebra, as well as presenting an approach to computing Krawtchouk expansions. From a mathematical perspective, we are providing indications as to how to implement in finite terms Rota's "finite operator calculus".Comment: 26 pages. Added material on Krawtchouk polynomials. Additional references include

Rapamycin inhibits ALDH activity, resistance to oxidative stress, and metastatic potential in murine osteosarcoma cells

Osteosarcoma (OS) is the most common primary malignancy of bone. Mortality is determined by the presence of metastatic disease, but little is known regarding the biochemical events that drive metastases. Two murine OS cell lines, K7M2 and K12, are related but differ significantly in their metastatic potentials: K7M2 is highly metastatic whereas K12 displays much less metastatic potential. Using this experimental system, the mammalian target of rapamycin (mTOR) pathway has been implicated in OS metastasis. We also discovered that aldehyde dehydrogenase (ALDH, a stem cell marker) activity is higher in K7M2 cells than K12 cells. Rapamycin treatment reduces the expression and enzymatic activity of ALDH in K7M2 cells. ALDH inhibition renders these cells more susceptible to apoptotic death when exposed to oxidative stress. Furthermore, rapamycin treatment reduces bone morphogenetic protein-2 (BMP2) and vascular endothelial growth factor (VEGF) gene expression and inhibits K7M2 proliferation, migration, and invasion in vitro. Inhibition of ALDH with disulfiram correlated with decreased mTOR expression and activity. In conclusion, we provide evidence for interaction between mTOR activity, ALDH activity, and metastatic potential in murine OS cells. Our work suggests that mTOR and ALDH are therapeutic targets for the treatment and prevention of OS metastasis. © 2013 Xiaodong Mu et al

Characterization of the South Atlantic marine boundary layer aerosol using an Aerodyne Aerosol Mass Spectrometer

International audienceMeasurements of the submicron fraction of the atmospheric aerosol in the marine boundary layer were performed from January to March 2007 (Southern Hemisphere summer) onboard the French research vessel Marion Dufresne in the Southern Atlantic and Indian Ocean (20° S?60° S, 70° W?60° E). For chemical composition measurements an Aerodyne High-Resolution-Time-of-Flight AMS was used to measure mass concentrations and species-resolved size distributions of non-refractory aerosol components in the submicron range. Within the "standard" AMS compounds (ammonium, chloride, nitrate, sulfate, organics) "sulfate" is the dominating species in the marine boundary layer reaching concentrations between 50 ng m?3 and 3 ?g m?3. Furthermore, what is seen as "sulfate" by the AMS seems to be mostly sulfuric acid. Another sulfur containing species that can ubiquitously be found in marine environments is methanesulfonic acid (MSA). Since MSA has not been directly measured before with an AMS, and is not part of the standard AMS analysis, laboratory experiments needed to be performed in order to be able to identify it within the AMS raw data and to extract mass concentrations for MSA from the field measurements. To identify characteristic air masses and their source regions backwards trajectories were used and averaged concentrations for AMS standard compounds were calculated for each air mass type. Sulfate mass size distributions were measured for these periods showing a distinct difference between oceanic air masses and those from African outflow. While the peak size in the mass distribution was roughly 250 nm in marine air masses it was shifted to 470 nm in African outflow air. Correlations between the mass concentrations of sulfate, organics and MSA were calculated which show a narrow correlation for MSA with sulfate/sulfuric acid coming from the ocean but not with continental sulfate

High energy neutrino yields from astrophysical sources II: Magnetized sources

We calculate the yield of high energy neutrinos produced in astrophysical sources for arbitrary interaction depths $\tau_0$ and magnetic field strengths $B$. We take into account energy loss processes like synchrotron radiation and diffusion of charged particles in turbulent magnetic fields as well as the scattering of secondaries on background photons and the direct production of charm neutrinos. Meson-photon interactions are simulated with an extended version of the SOPHIA model. Diffusion leads to an increased path-length before protons leave the source of size R_s and therefore magnetized sources lose their transparency below the energy $E\sim 10^{18}{\rm eV} (R_s/{\rm pc}) (B/{\rm mG}) \tau_0^{1/\alpha}$, with $\alpha=1/3$ and 1 for Kolmogorov and Bohm diffusion, respectively. Moreover, the neutrino flux is suppressed above the energy where synchrotron energy losses become important for charged particles. As a consequence, the energy spectrum and the flavor composition of neutrinos are strongly modified both at low and high energies even for sources with \tau_0\lsim 1.Comment: 15 pages, 16 figure