A leader election algorithm for dynamic networks with causal clocks

An algorithm for electing a leader in an asynchronous network with dynamically changing communication topology is presented. The algorithm ensures that, no matter what pattern of topology changes occurs, if topology changes cease, then eventually every connected component contains a unique leader. The algorithm combines ideas from the Temporally Ordered Routing Algorithm for mobile ad hoc networks (Park and Corson in Proceedings of the 16th IEEE Conference on Computer Communications (INFOCOM), pp. 1405–1413 (1997) with a wave algorithm (Tel in Introduction to distributed algorithms, 2nd edn. Cambridge University Press, Cambridge, MA, 2000), all within the framework of a height-based mechanism for reversing the logical direction of communication topology links (Gafni and Bertsekas in IEEE Trans Commun C–29(1), 11–18 1981). Moreover, a generic representation of time is used, which can be implemented using totally-ordered values that preserve the causality of events, such as logical clocks and perfect clocks. A correctness proof for the algorithm is provided, and it is ensured that in certain well-behaved situations, a new leader is not elected unnecessarily, that is, the algorithm satisfies a stability condition.National Science Foundation (U.S.) (0500265)Texas Higher Education Coordinating Board (ARP-00512-0007-2006)Texas Higher Education Coordinating Board (ARP 000512-0130-2007)National Science Foundation (U.S.) (IIS-0712911)National Science Foundation (U.S.) (CNS-0540631)National Science Foundation (U.S.) (Research Experience for Undergraduates (Program) (0649233)

The Advantages of Polymer Composites with Detonation Nanodiamond Particles for Medical Applications

ISBN 978-953-307-271-

YETI observations of the young transiting planet candidate CVSO 30 b

CVSO 30 is a unique young low-mass system, because, for the first time, a close-in transiting and a wide directly imaged planet candidates are found around a common host star. The inner companion, CVSO 30 b, is the first possible young transiting planet orbiting a previously known weak-lined T-Tauri star. With five telescopes of the 'Young Exoplanet Transit Initiative' (YETI) located in Asia, Europe and South America we monitored CVSO 30 over three years in a total of 144 nights and detected 33 fading events. In two more seasons we carried out follow-up observations with three telescopes. We can confirm that there is a change in the shape of the fading event between different observations and that the fading event even disappears and reappears. A total of 38 fading event light curves were simultaneously modelled. We derived the planetary, stellar, and geometrical properties of the system and found them slightly smaller but in agreement with the values from the discovery paper. The period of the fading event was found to be 1.36 s shorter and 100 times more precise than the previous published value. If CVSO 30 b would be a giant planet on a precessing orbit, which we cannot confirm, yet, the precession period may be shorter than previously thought. But if confirmed as a planet it would be the youngest transiting planet ever detected and will provide important constraints on planet formation and migration time-scales.Comment: 14 pages (20 with appendix), 7 figures (16 with appendix), 6 tables (7 with appendix

The composition of the protosolar disk and the formation conditions for comets

Conditions in the protosolar nebula have left their mark in the composition of cometary volatiles, thought to be some of the most pristine material in the solar system. Cometary compositions represent the end point of processing that began in the parent molecular cloud core and continued through the collapse of that core to form the protosun and the solar nebula, and finally during the evolution of the solar nebula itself as the cometary bodies were accreting. Disentangling the effects of the various epochs on the final composition of a comet is complicated. But comets are not the only source of information about the solar nebula. Protostellar disks around young stars similar to the protosun provide a way of investigating the evolution of disks similar to the solar nebula while they are in the process of evolving to form their own solar systems. In this way we can learn about the physical and chemical conditions under which comets formed, and about the types of dynamical processing that shaped the solar system we see today. This paper summarizes some recent contributions to our understanding of both cometary volatiles and the composition, structure and evolution of protostellar disks.Comment: To appear in Space Science Reviews. The final publication is available at Springer via http://dx.doi.org/10.1007/s11214-015-0167-

Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1

In a previous study it was found that the therapeutic effects of QLT0267, a small molecule inhibitor of integrin-linked kinase (ILK), were influenced by Her2/neu expression. To understand how inhibition or silencing of ILK influences Her2/neu expression, Her2/neu signaling was evaluated in six Her2/neu-positive breast cancer cell lines (LCC6Her2, MCF7Her2, SKBR3, BT474, JIMT-1 and KPL-4). Treatment with QLT0267 engendered suppression (32–87%) of total Her2/neu protein in these cells. Suppression of Her2/neu was also observed following small interfering RNA-mediated silencing of ILK expression. Time course studies suggest that ILK inhibition or silencing caused transient decreases in P-AKTser473, which were not temporally related to Her2/neu downregulation. Attenuation of ILK activity or expression was, however, associated with decreases in YB-1 (Y-box binding protein-1) protein and transcript levels. YB-1 is a known transcriptional regulator of Her2/neu expression, and in this study it is demonstrated that inhibition of ILK activity using QLT0267 decreased YB-1 promoter activity by 50.6%. ILK inhibition was associated with changes in YB-1 localization, as reflected by localization of cytoplasmic YB-1 into stress granules. ILK inhibition also suppressed TWIST (a regulator of YB-1 expression) protein expression. To confirm the role of ILK on YB-1 and TWIST, cells were engineered to overexpress ILK. This was associated with a fourfold increase in the level of YB-1 in the nucleus, and a 2- and 1.5-fold increase in TWIST and Her2/neu protein levels, respectively. Taken together, these data indicate that ILK regulates the expression of Her2/neu through TWIST and YB-1, lending support to the use of ILK inhibitors in the treatment of aggressive Her2/neu-positive tumors