Current Hypotheses on How Microsatellite Instability Leads to Enhanced Survival of Lynch Syndrome Patients

High levels of microsatellite instability (MSI-high) are a cardinal feature of colorectal tumors from patients with Lynch Syndrome. Other key characteristics of Lynch Syndrome are that these patients experience fewer metastases and have enhanced survival when compared to patients diagnosed with microsatellite stable (MSS) colorectal cancer. Many of the characteristics associated with Lynch Syndrome including enhanced survival are also observed in patients with sporadic MSI-high colorectal cancer. In this review we will present the current state of knowledge regarding the mechanisms that are utilized by the host to control colorectal cancer in Lynch Syndrome and why these same mechanisms fail in MSS colorectal cancers

Tumors Metastatic to Thyroid Neoplasms: A Case Report and Review of the Literature

Metastasis into a thyroid neoplasm—tumor-to-tumor metastasis—is exceedingly rare. We describe the 28th documented case of a tumor metastatic to a thyroid neoplasm and review the literature on tumor-to-tumor metastasis involving a thyroid neoplasm as recipient. All cases showed a recipient thyroid neoplasm with an abrupt transition to a morphologically distinct neoplasm. Metastasis into primary thyroid neoplasm was synchronous in 33% of cases and metachronous in 67%. Follicular adenoma was the most common recipient thyroid neoplasm overall (16/28), and papillary thyroid carcinoma was the most common malignant recipient neoplasm (9/28). Of the 9 recipient papillary carcinomas, 6 were follicular variants. Renal cell carcinoma was the most common neoplasm to metastasize to a primary thyroid neoplasm (9/28), followed by lung (6/28), breast (5/28), and colon (3/28) carcinoma. Tumor-to-tumor metastasis should be considered whenever a dimorphic pattern is encountered in a thyroid tumor

Deformability of Human Mesenchymal Stem Cells Is Dependent on Vimentin Intermediate Filaments

Mesenchymal stem cells (MSCs) are being studied extensively due to their potential as a therapeutic cell source for many load-bearing tissues. Compression of tissues and the subsequent deformation of cells are just one type physical strain MSCs will need to withstand in vivo. Mechanotransduction by MSCs and their mechanical properties are partially controlled by the cytoskeleton, including vimentin intermediate filaments (IFs). Vimentin IF deficiency has been tied to changes in mechanosensing and mechanical properties of cells in some cell types. However, how vimentin IFs contribute to MSC deformability has not been comprehensively studied. Investigating the role of vimentin IFs in MSC mechanosensing and mechanical properties will assist in functional understanding and development of MSC therapies. In this study, we examined vimentin IFs’ contribution to MSCs’ ability to deform under external deformation using RNA interference. Our results indicate that a deficient vimentin IF network decreases the deformability of MSCs, and that this may be caused by the remaining cytoskeletal network compensating for the vimentin IF network alteration. Our observations introduce another piece of information regarding how vimentin IFs are involved in the complex role the cytoskeleton plays in the mechanical properties of cells

Overview of Auditing Cloud Consistency

Cloud storage services have become very popular due to their infinite advantages. To provide always-on access, a cloud service provider (CSP) maintains multiple copies for each piece of data on geographically distributed servers. A major disadvantage of using this technique in clouds is that it is very expensive to achieve strong consistency on a worldwide scale. In this system, a novel consistency as a service (CaaS) model is presented, which involves a large data cloud and many small audit clouds. In the CaaS model we are presented in our system, a data cloud is maintained by a CSP. A group of users that participate an audit cloud can verify whether the data cloud provides the promised level of consistency or not. The system proposes a two level auditing architecture, which need a loosely synchronize clock in the audit cloud. Then design algorithms to measure the severity of violations with two metrics: the commonality of violations, and the oldness value of read. Finally, heuristic auditing strategy (HAS) is devised to find out as many violations as possible. Many experiments were performed using a combination of simulations and a real cloud deployment to validate HAS. DOI: 10.17762/ijritcc2321-8169.15011

Repeatability and Reproducibility of Macular Thickness Measurements Using Fourier Domain Optical Coherence Tomography

Aim: To evaluate repeatability and reproducibility of macular thickness measurements in visually normal eyes using the Topcon 3D OCT-1000. Methods: Phase 1 investigated scan repeatability, the effect of age and pupil dilation. Two groups (6 younger and 6 older participants) had one eye scanned 5 times pre and post- dilation by 1 operator. Phase 2 investigated between-operator, within and between-visit reproducibility. 10 participants had 1 un-dilated eye scanned 3 times on 2 separate visits by 2 operators. Results: Phase 1: No significant difference existed between repeat scans (p=0.75) and no significant difference was found pre- and post-dilation (p=0.54). In the younger group variation was low (95% limits ± 3.62 m) and comparable across all retinal regions. The older group demonstrated greater variation (95% limits ± 7.6 m). Phase 2: For a given retinal location, 95% confidence limits for within-operator, within-visit reproducibility was 5.16 m. This value increased to 5.56 m for the same operator over two visits and to 6.18 m for two operators over two visits. Conclusion: A high level repeatability, close to 6 m, of macular thickness measurement is possible using the 3D OCT- 1000. Measured differences in macular thickness between successive visits that exceed 6 m in pre-presbyopic individuals are therefore likely to reflect actual structural change. OCT measures are more variable in older individuals and it is advisable to take a series of scans so that outliers can be more easily identified

Eleven years of radio monitoring of the Type IIn supernova SN 1995N

We present radio observations of the optically bright Type IIn supernova SN 1995N. We observed the SN at radio wavelengths with the Very Large Array (VLA) for 11 years. We also observed it at low radio frequencies with the Giant Metrewave Radio Telescope (GMRT) at various epochs within $6.5-10$ years since explosion. Although there are indications of an early optically thick phase, most of the data are in the optically thin regime so it is difficult to distinguish between synchrotron self absorption (SSA) and free-free absorption (FFA) mechanisms. However, the information from other wavelengths indicates that the FFA is the dominant absorption process. Model fits of radio emission with the FFA give reasonable physical parameters. Making use of X-ray and optical observations, we derive the physical conditions of the shocked ejecta and the shocked CSM.Comment: 22 pages, 2 tables, 13 figures, Accepted for publication in Astrophysical Journa