663 research outputs found
False Face Must Hide What the False Heart Doth Know: Review and Model of Workplace Microaggression
Microaggression contains elements of workplace aggression, bullying, incivility, stigmatization, and ostracism. We argue that studies of the phenomenon should be broadened to cover all workplace members. Anyone with distinctly different ascribed status, physical and/or psychological characteristics from the mainstream may be subjected to negative micro-acts. We address two questions of concern: Why microaggression has not been recognized to be as problematic in ânormalizedâ work settings as with bullying and harassment, and how workers exposed to such micro-aggressive acts might respond. Theories of signal detection and coordinated management of meaning are used to explain how targets attribute the reasons for these negative acts, and manage to either mitigate or prevent them. We suggest ways of reducing the prevalence of microaggression by coordinating the management of meaning between the perceiver-as-target and the perpetrator. This leads to adaptive coping (Marrs, 2012) and fosters supportive workplace climates (Kim et al., 2018). Implications for workplace practices and policies are provided
Dogâassisted interventions and outcomes for older adults in residential longâterm care facilities: a systematic review and metaâanalysis
Objective
To comprehensively review studies on dogâassisted interventions (DAIs) among older people in residential longâterm care facilities (RLTCFs) and to provide an overview of their interventions, outcomes and methodological quality.
Method
We searched 18 electronic databases to identify English articles (published January 2000âDecember 2019) reporting on wellâdefined DAIs targeting older adults (â„65 years) in RLTCF. Data were extracted by two independent reviewers. Descriptive statistics were produced for quantitative studies, with key themes identified among qualitative studies. Where possible, estimates were pooled from randomised controlled trials using random effects metaâanalyses.
Results
Fortyâthree relevant studies (39 quantitative; 4 qualitative) were identified. The majority of quantitative studies were assessed as lowâquality according to the MMAT criteria (n = 26, 67%). Almost half of the quantitative studies (n = 18, 46%) found no significant changes over time or between groups across outcomes measured. The most salient intervention effects included improved social functioning (n = 10), reduced depressive symptoms (n = 6) and loneliness (n = 5). A randomâeffects metaâanalysis revealed a medium effect in favour of DAT on reducing depressive or loneliness symptoms (pooled SMD: 0.66, 95%CI 0.21â1.11; I2 = 50.5; five trials), relative to treatment as usual. However, compared to treatment as usual, no overall effect of DAI on activities of daily living was detected (p = .737). Key themes from qualitative studies included (a) animals as effective transitional objects, (b) the therapeutic value of pets and (c) the significance of the care environment and stakeholders in facilitating DAI.
Implications for practice
The findings of this review indicate that while DAI has value for older people in RLTCF, challenges remain in accurately measuring its impact to provide a stronger evidenceâbase. Standardisation of DAI service design, delivery and evaluation is required for future research and practice in providing holistic care for older adults
Fermi Surface Reconstruction in CeRhCoIn
The evolution of the Fermi surface of CeRhCoIn was studied as
a function of Co concentration via measurements of the de Haas-van Alphen
effect. By measuring the angular dependence of quantum oscillation frequencies,
we identify a Fermi surface sheet with -electron character which undergoes
an abrupt change in topology as is varied. Surprisingly, this
reconstruction does not occur at the quantum critical concentration ,
where antiferromagnetism is suppressed to T=0. Instead we establish that this
sudden change occurs well below , at the concentration x ~ 0.4 where long
range magnetic order alters its character and superconductivity appears. Across
all concentrations, the cyclotron effective mass of this sheet does not
diverge, suggesting that critical behavior is not exhibited equally on all
parts of the Fermi surface.Comment: 4 pages, 4 figure
Irregular vector turbo codes with low complexity
The term Block Turbo Code typically refers to the iterative decoding of a serially concatenated two-dimensional systematic block code. This paper introduces a Vector Turbo Code that is irregular but with code rates comparable to those of a Block Turbo Code (BTC) when the Bahl Cocke Jelinek Raviv algorithm is used. In BTCâs, the horizontal (or vertical) blocks are encoded first and the vertical (or horizontal) blocks second. The irregular Vector Turbo Code (iVTC) uses information bits that participate in varying numbers of trellis sections, which are organized into blocks that are encoded horizontally (or vertical) without vertical (or horizontal) encoding. The decoding requires only one soft-input soft-output decoder. In general, a reduction in complexity, in comparison to a BTC was achieved for the same very low probability of bit error (10â5). Performance in the AWGN channel shows that iVTC is capable of achieving a significant coding gain of 1.28dB for a 64QAM modulation scheme, at a bit error rate of 10â5over its corresponding BTC. Simulation results also show that some of these codes perform within 0.49dB of capacity for binary transmission over an AWGN channel
Direct IF sampling receivers for 5G millimeter-wave communications systems
Reducing receiver complexity and power consumption are important design goals in fifth-generation (5G) millimeter-wave (mm-wave) communications systems. One approach for achieving these goals is to employ direct intermediate frequency (IF) sampling at sub-Nyquist rates in a superheterodyne receiver architecture using digital downconversion of the IF signal. This paper presents original measured results characterizing in detail the signal-to-noise-ratio (SNR), error vector magnitude (EVM), and block error rate (BLER) performances of a direct IF subsampling mm-wave receiver with subsampling rate as a parameter. A software-defined radio (SDR) receiver using direct IF subsampling was implemented in a 28GHz, beamforming, over-the-air (OTA), hardware-in-the-loop (HWIL), SDR testbed using a 2.52 GHz IF. For a quadrature phase shift keying (QPSK) modulated long-term evolution (LTE) signal subsampled at 500 MHz, a small SNR penalty of Ë3dB at 5% BLER was obtained over a 10 GHz Nyquist sampling benchmark
How Newly Acquainted Dyads Develop Shared Stereotypic Impressions through Conversation
Solubilization of Proteins in 2DE: An Outline
Protein solubilization for two-dimensional electrophoresis (2DE) has to break
molecular interactions to separate the biological contents of the material of
interest into isolated and intact polypeptides. This must be carried out in
conditions compatible with the first dimension of 2DE, namely isoelectric
focusing. In addition, the extraction process must enable easy removal of any
nonprotein component interfering with the isoelectric focusing. The constraints
brought in this process by the peculiar features of isoelectric focusing are
discussed, as well as their consequences in terms of possible solutions and
limits for the solubilization process
Alcohol interventions, alcohol policy and intimate partner violence: a systematic review
Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells
Chemotherapy using temozolomide is the standard treatment for patients with glioblastoma. Despite treatment, prognosis is still poor largely due to the emergence of temozolomide resistance. This resistance is closely linked to the widely recognized inter- and intra-tumoral heterogeneity in glioblastoma, although the underlying mechanisms are not yet fully understood. To induce temozolomide resistance, we subjected 21 patient-derived glioblastoma cell cultures to Temozolomide treatment for a period of up to 90 days. Prior to treatment, the cellsâ molecular characteristics were analyzed using bulk RNA sequencing. Additionally, we performed single-cell RNA sequencing on four of the cell cultures to track the evolution of temozolomide resistance. The induced temozolomide resistance was associated with two distinct phenotypic behaviors, classified as âadaptiveâ (ADA) or ânon-adaptiveâ (N-ADA) to temozolomide. The ADA phenotype displayed neurodevelopmental and metabolic gene signatures, whereas the N-ADA phenotype expressed genes related to cell cycle regulation, DNA repair, and protein synthesis. Single-cell RNA sequencing revealed that in ADA cell cultures, one or more subpopulations emerged as dominant in the resistant samples, whereas N-ADA cell cultures remained relatively stable. The adaptability and heterogeneity of glioblastoma cells play pivotal roles in temozolomide treatment and contribute to the tumorâs ability to survive. Depending on the tumorâs adaptability potential, subpopulations with acquired resistance mechanisms may arise.</p
Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres
[EN] Hydrogenated amorphous silicon colloids of low surface area (<5 m(2)/g) are shown to exhibit complete in-vitro biodegradation into orthosilicic acid within 10-15 days at 37 degrees C. When converted into polycrystalline silicon colloids, by high temperature annealing in an inert atmosphere, microparticle solubility is dramatically reduced. The data suggests that amorphous silicon does not require nanoscale porosification for full in-vivo biodegradability. This has significant implications for using a-Si:H coatings for medical implants in general, and orthopedic implants in particular. The high sphericity and biodegradability of submicron particles may also confer advantages with regards to contrast agents for medical imaging.This work has been partially supported by the Spanish CICyT projects, FIS2009-07812, Consolider CSD2007-046, MAT2009-010350 and PROMETEO/2010/043.Shabir, Q.; Pokale, A.; Loni, A.; Johnson, DR.; Canham, L.; Fenollosa Esteve, R.; Tymczenko, MK.... (2011). Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres. Silicon. 3(4):173-176. https://doi.org/10.1007/s12633-011-9097-4S17317634Salonen J, Kaukonen AM, Hirvonen J, Lehto VP (2008) J Pharmaceutics 97:632â53Anglin EJ, Cheng L, Freeman WR, Sailor MJ (2008) Adv Drug Deliv Rev 60:1266â77OâFarrell N, Houlton A, Horrocks BR (2006) Int J Nanomedicine 1:451â72Canham LT (1995) Adv Mater 7:1037, PCT patent WO 97/06101,1999Park JH, Gui L, Malzahn G, Ruoslahti E, Bhatia SN, Sailor MJ (2009) Nature Mater 8:331â6Cullis AG, Canham LT, Calcott PDJ (1997) J Appl Phys 82:909â66Canham LT, Reeves CR (1996) Mat Res Soc Symp 414:189â90Edell DJ, Toi VV, McNeil VM, Clark LD (1992) IEEE Trans Biomed Eng 39:635â43Fenollosa R, Meseguer F, Tymczenko M (2008) Adv Mater 20:95Fenollosa R, Meseguer F, Tymczenko M, Spanish Patent P200701681, 2007Pell LE, Schricker AD, Mikulec FV, Korgel BA (2004) Langmuir 20:6546XifrĂ©-Perez E, Fenollosa R, Meseguer F (2011) Opt Express 19:3455â63Fenollosa R, Ramiro-Manzano F, Tymczenko M, Meseguer F (2010) J Mater Chem 20:5210XifrĂ©-PĂ©rez E, Domenech JD, Fenollosa R, Muñoz P, Capmany J, Meseguer F (2011) Opt Express 19â4:3185â92Rodriguez I, Fenollosa R, Meseguer F, Cosmetics & Toiletries 2010;42â49Ramiro-Manzano F, Fenollosa R, XifrĂ©-PĂ©rez E, GarĂn M, Meseguer F (2011) Adv Mater 23:3022â3025. doi: 10.1002/adma.201100986Iler RK (1979) Chemistry of silica: solubility, polymerization, colloid & surface properties & biochemistry. Wiley, New YorkTanaka K, Maruyama E, Shimado T, Okamoto H (1999) Amorphous silicon. Wiley, New York, NYPatterson AL (1939) Phys Rev 56:978â82Canham LT, Reeves CL, King DO, Branfield PJ, Gabb JG, Ward MC (1996) Adv Mater 8:850â2Iler RK In: Chemistry of silica: solubility, polymerization, colloid & surface properties &Biochemistry. Wiley, New York, NYFinnie KS, Waller DJ, Perret FL, Krause-Heuer AM, Lin HQ, Hanna JV, Barbe CJ (2009) J Sol-Gel Technol 49:12â8Zhao D, Huo Q, Feng J, Chmelka BF, Stucky GD (1998) J Am Chem Soc 120:6024â36Fan D, Akkaraju GR, Couch EF, Canham LT, Coffer JL (2010) Nanoscale 1:354â61Tasciotti E, Godin B, Martinez JO, Chiappini C, Bhavane R, Liu X, Ferrari M (2011) Mol Imaging 10:56â
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