Schwannomatosis of the Spinal Accessory Nerve: A Case Report.

Schwannomatosis is a distinct syndrome characterized by multiple peripheral nerve schwannomas that can be sporadic or familial in nature. Cases affecting the lower cranial nerves are infrequent. Here, the authors present a rare case of schwannomatosis affecting the left spinal accessory nerve. Upon genetic screening, an in-frame insertion at codon p.R177 of the Sox 10 gene was observed. There were no identifiable alterations in NF1, NF2, LZTR1, and SMARCB1. This case demonstrates a rare clinical presentation of schwannomatosis in addition to a genetic aberration that has not been previously reported in this disease context

Counting What Is Measured or Measuring What Counts? League Tables and Their Impact On Higher Education Institutions in England

This report investigates league tables and their impact on higher education institutions (HEIs) in England. It presents findings from two strands of research: – an analysis of five league tables selected for the study, their methodologies and the underlying data employed, and – an investigation of how higher education institutions respond to league tables generally and the extent to which they influence institutional decision-making and actions. The purpose of the research is to stimulate informed debate about the approaches and limitations of the various league tables, and greater understanding among the users and stakeholders of the implications of making decisions based on these sources of information

Three-point correlations for quantum star graphs

We compute the three point correlation function for the eigenvalues of the Laplacian on quantum star graphs in the limit where the number of edges tends to infinity. This extends a work by Berkolaiko and Keating, where they get the 2-point correlation function and show that it follows neither Poisson, nor random matrix statistics. It makes use of the trace formula and combinatorial analysis.Comment: 10 pages, 2 figure

Pressure Line Broadening and Feasibility of CO_2 Profile Retrieval using Near Infrared Observations of an Absorption Line

Analytic expressions are derived for the transmittance and reflectance of sunlight and their Jacobians for an absorption line with Lorentz line broadening. Rodgers information analysis is applied to calculate the information content, the degrees of freedom and the averaging kernel for a simple atmospheric model to investigate the feasibility of retrieving the profile of CO_2 using near-infrared (NIR) measurements over a single absorption line. The results have implications for the design of future space instruments with high spectral resolution and high signal to noise ratios to obtain global scale information on the CO_2 vertical distribution which is important for inferring the sources, sinks, and transport of CO_2

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse

The cytoplasmic dynein complex is fundamentally important to all eukaryotic cells for transporting a variety of essential cargoes along microtubules within the cell. This complex also plays more specialized roles in neurons. The complex consists of 11 types of protein that interact with each other and with external adaptors, regulators and cargoes. Despite the importance of the cytoplasmic dynein complex, we know comparatively little of the roles of each component protein, and in mammals few mutants exist that allow us to explore the effects of defects in dynein-controlled processes in the context of the whole organism. Here we have taken a genotype-driven approach in mouse (Mus musculus) to analyze the role of one subunit, the dynein light intermediate chain 1 (Dync1li1). We find that, surprisingly, an N235Y point mutation in this protein results in altered neuronal development, as shown from in vivo studies in the developing cortex, and analyses of electrophysiological function. Moreover, mutant mice display increased anxiety, thus linking dynein functions to a behavioral phenotype in mammals for the first time. These results demonstrate the important role that dynein-controlled processes play in the correct development and function of the mammalian nervous system