357 research outputs found
CHANGES OF IMMUNOLOGICAL RESISTANCE AS A POSSIBLE CRITERION FOR THE RISK OF THE POPULATION RESIDING INDUSTRIAL ZONE
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Finding an Effective Metric Used for Bijective S-Box Generation by Genetic Algorithms
In cryptography, S-box is a basic component of symmetric key algorithms which performs nonlinear substitution. S-boxes need to be highly nonlinear, so that the cipher can resist linear cryptanalysis.
The main criteria for cryptographically strong (n × n) S-box are:
• High non linearity;
• High algebraic degree;
• Balanced structure;
• Good auto correlation properties.
Our task was to give some suggestions for finding an effective metric used for generation bijective optimal S-Box. Because of the given problem’s complexity, our group considered different approaches and we gave a few suggestions for problem solving
Salen Mn Complexes Mitigate Radiation Injury in Normal Tissues
Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes some of this research, focusing on several tissues of therapeutic interest, namely kidney, lung, skin, and oral mucosa. These studies have demonstrated suppression of delayed radiation injury in animals treated with EUK-189 and/or EUK-207. While an antioxidant mechanism of action is postulated, it is likely that the mechanisms of radiation mitigation by these compounds in vivo are complex and may differ in the various target tissues. Indicators of oxidative stress are increased in lung and skin radiation injury models, and suppressed by salen Mn complexes. The role of oxidative stress in the renal injury model is unclear, though EUK-207 does mitigate. In certain experimental models, salen Mn complexes have shown “mito-protective” properties, that is, attenuating mitochondrial injury. Consistent with this, EUK-134 suppresses effects of ionizing radiation on mitochondrial function in rat astrocyte cultures. In summary, salen Mn complexes could be useful to mitigate delayed radiation injury to normal tissues following radiation therapy, accidental exposure, or radiological terrorism. Optimization of their mode of delivery and other key pharmaceutical properties, and increasing understanding of their mechanism(s) of action as radiation mitigators, are key issues for future study
On fatigue behavior of two spring steels. Part I: Wöhler curves and fractured surfaces
Symmetric fatigue in two spring steels is investigated in three groups of specimens. One of the groups (Steel EN10270-1SH/ DIN 17223C – C 0.82%, Mn 0.76%, Si 0.26%) has experienced rotating-bending fatigue in air, and the other two groups (Steel BS250A53/ DIN 55Si7 – C 0.56%, Mn 0.81%, Si 1.85%), torsion fatigue in-air and corrosion environment. Fatigue life-time data are obtained for both spring steels, and their corresponding Wöhler curves plotted and mathematically described. Surface short fatigue cracks are observed from origin to fracture by using acetate-foil replication technique, and their length, a, measured at the corresponding number of fatigue cycles, N. Those data are presented in plots “Crack lengths, a – Cycles, N” and a comparison made between both the steels. The fractured surfaces of all specimens have been studied and analyzed by the scanning-electron microscopy method
On fatigue behaviour of two spring steels. Part II: Mathematical models
Symmetric fatigue in two spring steels is investigated in three groups of specimens. One of the groups (Steel EN10270-1SH/ DIN 17223C – C 0.82%, Mn 0.76%, Si 0.26%) has experienced rotating-bending fatigue in air, and the other two groups (Steel BS250A53/ DIN 55Si7 – C 0.56%, Mn 0.81%, Si 1.85%), torsion fatigue in-air and corrosion environment. All experiments include testing to fracture, applying acetate-foil replication technique, replica monitoring of short crack surface growth, length measuring of propagating cracks, a, at the corresponding number of fatigue cycles, N. Data obtained from replica monitoring are presented in plots “Crack lengths, a – Cycles, N”, and used for calculating fatigue crack growth rates, da/dN, and graphical presentations “Crack growth rates, da/dN – Crack lengths, a”. A mathematical description of da/dN – a is presented by introducing a parabolic-linear model in different versions for each of the steels. The model versions are verified through comparing the experimental fatigue lifetimes with those calculated by the proposed model version
Scientific mindfulness: a foundation for future themes in international business
We conceptualize new ways to qualify what themes should dominate the future IB
research agenda by examining three questions: Whom should we ask? What should we ask and which selection criteria should we apply? What are the contextual forces? We propose scientific mindfulness as the way forward for generating themes in IB research
The Lick AGN Monitoring Project 2011: Dynamical Modeling of the Broad-Line Region
We present models of the H-emitting broad-line region (BLR) in seven
Seyfert 1 galaxies from the Lick AGN (Active Galactic Nucleus) Monitoring
Project 2011 sample, drawing inferences on the BLR structure and dynamics as
well as the mass of the central supermassive black hole. We find that the BLR
is generally a thick disk, viewed close to face-on, with preferential emission
back toward the ionizing source. The dynamics in our sample range from
near-circular elliptical orbits to inflowing or outflowing trajectories. We
measure black hole masses of for PG 1310108, for Mrk 50,
for Mrk 141, for Mrk 279,
for Mrk 1511, for NGC 4593, and
for Zw 229015. We use these black hole mass
measurements along with cross-correlation time lags and line widths to recover
the scale factor used in traditional reverberation mapping measurements.
Combining our results with other studies that use this modeling technique,
bringing our sample size to 16, we calculate a scale factor that can be used
for measuring black hole masses in other reverberation mapping campaigns. When
using the root-mean-square (rms) spectrum and using the line dispersion to
measure the line width, we find . Finally, we search for correlations between and other AGN
and BLR parameters and find marginal evidence that is correlated with
and the BLR inclination angle, but no significant evidence of a
correlation with the AGN luminosity or Eddington ratio.Comment: 26 pages, 14 figures. Accepted for publication in Ap
The Lick AGN Monitoring Project 2011: Spectroscopic Campaign and Emission-Line Light Curves
In the Spring of 2011 we carried out a 2.5 month reverberation mapping
campaign using the 3 m Shane telescope at Lick Observatory, monitoring 15
low-redshift Seyfert 1 galaxies. This paper describes the observations,
reductions and measurements, and data products from the spectroscopic campaign.
The reduced spectra were fitted with a multicomponent model in order to isolate
the contributions of various continuum and emission-line components. We present
light curves of broad emission lines and the AGN continuum, and measurements of
the broad H-beta line widths in mean and root-mean square (rms) spectra. For
the most highly variable AGNs we also measured broad H-beta line widths and
velocity centroids from the nightly spectra. In four AGNs exhibiting the
highest variability amplitudes, we detect anticorrelations between broad H-beta
width and luminosity, demonstrating that the broad-line region "breathes" on
short timescales of days to weeks in response to continuum variations. We also
find that broad H-beta velocity centroids can undergo substantial changes in
response to continuum variations; in NGC 4593 the broad H-beta velocity shifted
by ~250 km/s over a one-month duration. This reverberation-induced velocity
shift effect is likely to contribute a significant source of confusion noise to
binary black hole searches that use multi-epoch quasar spectroscopy to detect
binary orbital motion. We also present results from simulations that examine
biases that can occur in measurement of broad-line widths from rms spectra due
to the contributions of continuum variations and photon-counting noise.Comment: 33 pages, 28 figures, accepted for publication in ApJ Supplement
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