Beam Performance of Tracking Detectors with Industrially Produced GEM Foils

Three Gas-Electron-Multiplier tracking detectors with an active area of 10 cm x 10 cm and a two-dimensional, laser-etched orthogonal strip readout have been tested extensively in particle beams at the Meson Test Beam Facility at Fermilab. These detectors used GEM foils produced by Tech-Etch, Inc. They showed an efficiency in excess of 95% and spatial resolution better than 70 um. The influence of the angle of incidence of particles on efficiency and spatial resolution was studied in detail.Comment: 8 pages, 9 figures, accepted by Nuclear Instruments and Methods in Physics Research

Dust in the Local Interstellar Wind

The gas-to-dust mass ratios found for interstellar dust within the Solar System, versus values determined astronomically for the cloud around the Solar System, suggest that large and small interstellar grains have separate histories, and that large interstellar grains preferentially detected by spacecraft are not formed exclusively by mass exchange with nearby interstellar gas. Observations by the Ulysses and Galileo satellites of the mass spectrum and flux rate of interstellar dust within the heliosphere are combined with information about the density, composition, and relative flow speed and direction of interstellar gas in the cloud surrounding the solar system to derive an in situ value for the gas-to-dust mass ratio, $R_{g/d} = 94^{+46}_{-38}$. Hubble observations of the cloud surrounding the solar system yield a gas-to-dust mass ratio of Rg/d=551+61-251 when B-star reference abundances are assumed. The exclusion of small dust grains from the heliosheath and heliosphere regions are modeled, increasing the discrepancy between interstellar and in situ observations. The shock destruction of interstellar grains is considered, and comparisons are made with interplanetary and presolar dust grains.Comment: 87 pages, 9 figures, 6 tables, accepted for publication in Astrophysical Journal. Uses AASTe

Insights into Tikhonov regularization: application to trace gas column retrieval and the efficient calculation of total column averaging kernels

Insights are given into Tikhonov regularization and its application to the retrieval of vertical column densities of atmospheric trace gases from remote sensing measurements. The study builds upon the equivalence of the least-squares profile-scaling approach and Tikhonov regularization method of the first kind with an infinite regularization strength. Here, the vertical profile is expressed relative to a reference profile. On the basis of this, we propose a new algorithm as an extension of the least-squares profile scaling which permits the calculation of total column averaging kernels on arbitrary vertical grids using an analytic expression. Moreover, we discuss the effective null space of the retrieval, which comprises those parts of a vertical trace gas distribution which cannot be inferred from the measurements. Numerically the algorithm can be implemented in a robust and efficient manner. In particular for operational data processing with challenging demands on processing time, the proposed inversion method in combination with highly efficient forward models is an asset. For demonstration purposes, we apply the algorithm to CO column retrieval from simulated measurements in the 2.3 μm spectral region and to O₃ column retrieval from the UV. These represent ideal measurements of a series of spaceborne spectrometers such as SCIAMACHY, TROPOMI, GOME, and GOME-2. For both spectral ranges, we consider clear-sky and cloudy scenes where clouds are modelled as an elevated Lambertian surface. Here, the smoothing error for the clear-sky and cloudy atmosphere is significant and reaches several percent, depending on the reference profile which is used for scaling. This underlines the importance of the column averaging kernel for a proper interpretation of retrieved column densities. Furthermore, we show that the smoothing due to regularization can be underestimated by calculating the column averaging kernel on a too coarse vertical grid. For both retrievals, this effect becomes negligible for a vertical grid with 20–40 equally thick layers between 0 and 50 km

Estudo preliminar do vermicomposto produzido a partir de lodo de esgoto doméstico e solo

O lodo de esgoto doméstico é um resíduo gerado durante os processos de tratamento de esgoto, podendo ser estabilizado por diversos processos químicos, físicos e biológicos. O lodo de esgoto estabilizado (biossólido) não possui um destino final adequado e gera diversos problemas no sentido de sua disposição final. Dentre os muitos processos que visam à disposição do biossólido, destaca-se a reciclagem agrícola. A utilização da vermicompostagem como meio de estabilização do lodo de esgoto mostra-se como uma ferramenta útil na estabilização deste resíduo. O processo de vermicompostagem apresentou características físico-químicas satisfatórias para ser utilizado como técnica de estabilização do lodo de esgoto doméstico. O produto final apresentou potencial para ser utilizado na agricultura como fertilizante ou condicionador de solos.Domestic waste, a residue generated during sewage treatments, can be stabilized by many chemical, physical and biological processes. However, the stabilized waste (biosoil) currently lacks proper disposal alternatives. A new and promising disposal method is called farm recycling. The use of vermicomposting has shown to be useful as a mean to stabilize domestic waste. The biosoil achieved through this method exhibits high humidity-retaining capacity, good C/N relationship, as well as a satisfactory percentage of humic acid, thus being able to be incorporated into the soil as a conditioner and fertilizer

REDUCTION in INFLAMMATORY MARKERS EXPRESSION in SERUM IS RELATED TO IMPROVEMENT in RENAL FUNCTIONS in INTRAUTERINE UNDERNOURISHED RATS

Univ São Paulo, Inst Biomed Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Nephrol, São Paulo, BrazilWeb of Scienc

Cleavable Biotin Probes for Labeling of Biomolecules via Azide−Alkyne Cycloaddition

The azide−alkyne cycloaddition provides a powerful tool for bio-orthogonal labeling of proteins, nucleic acids, glycans, and lipids. In some labeling experiments, e.g., in proteomic studies involving affinity purification and mass spectrometry, it is convenient to use cleavable probes that allow release of labeled biomolecules under mild conditions. Five cleavable biotin probes are described for use in labeling of proteins and other biomolecules via azide−alkyne cycloaddition. Subsequent to conjugation with metabolically labeled protein, these probes are subject to cleavage with either 50 mM Na_2S_2O_4, 2% HOCH_2CH_2SH, 10% HCO_2H, 95% CF_3CO_2H, or irradiation at 365 nm. Most strikingly, a probe constructed around a dialkoxydiphenylsilane (DADPS) linker was found to be cleaved efficiently when treated with 10% HCO_2H for 0.5 h. A model green fluorescent protein was used to demonstrate that the DADPS probe undergoes highly selective conjugation and leaves a small (143 Da) mass tag on the labeled protein after cleavage. These features make the DADPS probe especially attractive for use in biomolecular labeling and proteomic studies

Perspectives on Interstellar Dust Inside and Outside of the Heliosphere

Measurements by dust detectors on interplanetary spacecraft appear to indicate a substantial flux of interstellar particles with masses exceeding 10^{-12}gram. The reported abundance of these massive grains cannot be typical of interstellar gas: it is incompatible with both interstellar elemental abundances and the observed extinction properties of the interstellar dust population. We discuss the likelihood that the Solar System is by chance located near an unusual concentration of massive grains and conclude that this is unlikely, unless dynamical processes in the ISM are responsible for such concentrations. Radiation pressure might conceivably drive large grains into "magnetic valleys". If the influx direction of interstellar gas and dust is varying on a ~10 yr timescale, as suggested by some observations, this would have dramatic implications for the small-scale structure of the interstellar medium.Comment: 13 pages. To appear in Space Science Review

Bound - states for truncated Coulomb potentials

The pseudoperturbative shifted - $l$ expansion technique PSLET is generalized for states with arbitrary number of nodal zeros. Bound- states energy eigenvalues for two truncated coulombic potentials are calculated using PSLET. In contrast with shifted large-N expansion technique, PSLET results compare excellently with those from direct numerical integration.Comment: TEX file, 22 pages. To appear in J. Phys. A: Math. & Ge