Dysplastic Ichthyosis Uteri-like changes of the entire endometrium associated with a squamous cell carcinoma of the uterine cervix

Ichthyosis uteri is an exceedingly rare condition in which the entire surface of the endometrium is replaced by stratified squamous epithelium. Originally described as an endometrial response to iatrogenically-introduced caustic substances, similar changes have since been described in association with a variety of inflammatory conditions of the endometrium. We describe herein a heretofore undescribed example of a moderately differentiated squamous cell carcinoma of the uterine cervix associated with extensive ichthyosis uteri-like changes of the entire adjacent endometrium. Additionally, the squamous epithelium of the latter also showed multifocal changes diagnostic of a low-grade squamous intraepithelial lesion. The potential genesis of this composite of findings is discussed, as is the neoplastic potential of ichthyosis uteri. It is concluded that a squamous cell carcinoma of the cervix extended proximally into the endometrium, and that there was a colonization of a pre-existing ichthyosis uteri by associated human papillomavirus. The possibility of significant cervical pathology should be considered when plaques of squamous epithelium with low grade dysplastic changes are identified in an endometrial biopsy or curettage

Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma

<p>Abstract</p> <p>Background</p> <p>Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene <it>PON1</it>, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous <it>PON1 </it>polymorphisms and the risk of developing astrocytoma and meningioma.</p> <p>Methods</p> <p>Seventy one consecutive patients with brain tumors (43 with astrocytoma grade II/III and 28 with meningioma) with ages ranging 21 to 76 years, and 220 healthy controls subjects were analyzed for the frequency of the nonsynonymous <it>PON1 </it>genotypes L55M rs854560 and Q192R rs662. All participants were adult Caucasian individuals recruited in the central area of Spain.</p> <p>Results</p> <p>The frequencies of the <it>PON1 </it>genotypes and allelic variants of the polymorphisms <it>PON1 </it>L55M and <it>PON1 </it>Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. The minor allele frequencies were as follows: <it>PON1 </it>55L, 0.398, 0.328 and 0.286 for patients with astrocytoma, meningioma and control individuals, respectively; <it>PON1 </it>192R, 0.341, 0.362 and 0.302 for patients with astrocytoma, meningioma and control individuals, respectively. Correction for age, gender, or education, made no difference in odds ratios and the <it>p </it>values remained non-significant. Haplotype association analyses did not identify any significant association with the risk of developing astrocytoma or meningioma.</p> <p>Conclusions</p> <p>Common nonsynonymous <it>PON1 </it>polymorphisms are not related with the risk of developing astrocytoma and meningioma.</p

Flow and turbulence measurements in a diagonal brush fish pass: A field study

BAW;Schnabel Engineering7th IAHR International Symposium on Hydraulic Structures, ISHS 2018 -- 15 May 2018 through 18 May 2018 -- -- 139327This study aims to investigate flow and turbulence structure of a diagonal brush fish passage which has been constructed at the existing Small Hydropower Plant (SHP) on İyidere River on the East Black Sea Coast of Turkey. The flow and turbulence characteristics of diagonal brush fish pass were investigated in a 1.1 m wide rectangular flume with a bed slope of 10% for Reynolds and Froude numbers ranging between 3.45x104-2.4x105 and 0.15-0.16, respectively. By taking into account dynamic upstream water levels (H=101.20 m to H=102.05 m) of fish pass structure throughout the year, the vertical velocity profiles of different flow regions have been obtained by using Nivus instrument, whereas the turbulence quantities were gathered by measuring the three-dimensional instantaneous velocity fields using Micro acoustic Doppler velocimeter. The flow data was grouped for four different relative submergence of bristles. Thus, the analysis is done based on a physical basis and focus on the most important hydraulic parameters of velocity field, turbulence, and flow depth for fish passage design. The main findings of this study can be summarized as follows: (i) a significant proportion of energy dissipation (>50%) takes place in the brush plates with the vibration and bending of bristles, (ii) turbulent kinetic energy seems to be considerably lower for a same dissipated power in brush fish pass than other conventional fish passes (vertical slot and nature type), (iii) the turbulence intensities in the lateral velocity component were an important contributor to turbulence, and (iv) when the bristles are submerged, the maximum turbulent kinetic energy value is tripled. The flow is quasi-uniform and in subcritical regime which provides different migration corridors with typical hydraulic conditions and, very important for the fish, these corridors continue through the complete fish pass. The results from this study would be useful to fish-pass designers. © 2018 7th IAHR International Symposium on Hydraulic Structures, ISHS. All rights reserved.National Council for Scientific Research 315M019This work is supported by the Scientific and Technical Research Council of Turkey under Scientific and Technological Research Projects Funding Program (1001 TUBITAK) grant with agreement number 315M019

Early stage epithelial ovarian cancers: A study of morphologic prognostic factors

We intended to reevaluate the morphologic prognostic factors for early-stage ovarian carcinomas. We reviewed 111 patients diagnosed with early-stage ovarian cancer who had undergone primary surgery at Hacettepe Hospital between 1984 and 2001, using diagnostic criteria from the WHO-2003 classification. We applied the Universal grading system suggested by Shimizu/Silverberg and noted FIGO-stage, histotype, tumor size, bilaterality, and endometriosis. These features were compared with each other and survival. The survival analysis was carried out by Kaplan-Meier curves. Of the cases, 52 were reclassified as &#039;borderline tumor&#039; or &#039;cystadenoma with borderline foci&#039; and 59 as &#039;invasive carcinoma&#039;. FIGO-stage and mitotic count were significant for survivals of 59 patients with cancer. Mitotic index was also significant for the probability of metastasis. The patients with stage-II cancer had 5.65 times more risk of recurrence than stage-I cancer. The 5-year overall and disease-free survivals rates were 90.6% and 87.5% for stage-I, 54.7% and 39.3% for stage-II, respectively. Universal grade did not reach statistical significance for survivals but it was related to FIGO-stage significantly. In conclusion, FIGO-stage is the most reliable prognosticator. Although prognostic value of universal grade is not significant, mitotic count may provide important prognostic information for early-stage ovarian carcinomas