A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses

Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea & Araque (2007) demonstrated a role of astrocytes in induction of LTP at single hippocampal synapses. They suggested a purely pre-synaptic basis for induction of this N-methyl-D- Aspartate (NMDA) Receptor-independent LTP. Also, the mechanisms underlying this pre-synaptic induction were not investigated. Here, in this article, we propose a mathematical model for astrocyte modulated LTP which successfully emulates the experimental findings of Perea & Araque (2007). Our study suggests the role of retrograde messengers, possibly Nitric Oxide (NO), for this pre-synaptically modulated LTP.Comment: 51 pages, 15 figures, Journal of Computational Neuroscience (to appear

Expansion of Nature Conservation Areas: Problems with Natura 2000 Implementation in Poland?

In spite of widespread support from most member countries’ societies for European Union policy, including support for the sustainable development idea, in many EU countries the levels of acceptance of new environmental protection programmes have been and, in particular in new member states, still are considerably low. The experience of the countries which were the first to implement union directives show that they cannot be effectively applied without widespread public participation. The goal of this study was, using the example of Poland, to assess public acceptance of the expansion of nature conservation in the context of sustainable development principles and to discover whether existing nature governance should be modified when establishing new protected areas. The increase in protected areas in Poland has become a hotbed of numerous conflicts. In spite of the generally favourable attitudes to nature which Polish people generally have, Natura 2000 is perceived as an unnecessary additional conservation tool. Both local authorities and communities residing in the Natura areas think that the programme is a hindrance, rather than a help in the economic development of municipalities or regions, as was initially supposed. This lack of acceptance results from many factors, mainly social, historic and economic. The implications of these findings for current approach to the nature governance in Poland are discussed

When bicycle pump is harder to read than bicycle bell: Effects of parsing cues in first and second language compound reading

Lemhöfer K, Koester D, Schreuder R. When bicycle pump is harder to read than bicycle bell: Effects of parsing cues in first and second language compound reading. Psychonomic Bulletin & Review. 2011;18(2):364-370

Non-aqueous electrolyte solutions in chemistry and modern technology

In this paper a brief survey is given of the properties of non-aqueous electrolyte solutions and their applications in chemistry and technology without going into the details of theory. Specific solvent-solute interactions and the role of the solvent beyond its function as a homogenous isotropic medium are stressed. Taking into account Parker's statement1) ldquoScientists nowadays are under increasing pressure to consider the relevance of their research, and rightly sordquo we have included examples showing the increasing industrial interest in non-aqueous electrolyte solutions. The concepts and results are arranged in two parts. Part A concerns the fundamentals of thermodynamics, transport processes, spectroscopy and chemical kinetics of non-aqueous solutions and some applications in these fields. Part B describes their use in various technologies such as high-energy batteries, non-emissive electro-optic displays, photoelectrochemical cells, electrodeposition, electrolytic capacitors, electro-organic synthesis, metallurgic processes and others. Four Appendices are added. Appendix A gives a survey on the most important non-aqueous solvents, their physical properties and correlation parameters, and the commonly used abbreviations. Appendices B and C show the mathematical background of the general chemical model. The Symbols and abbreviations of the text are listed and explained in Appendix D

Epidemiology of and Risk Factors for BK Polyomavirus Replication and Nephropathy in Pediatric Renal Transplant Recipients: An International CERTAIN Registry Study

Background. BK polyomavirus-associated nephropathy (BKPyVAN) constitutes a serious cause of kidney allograft failure, but large-scale data in pediatric renal transplant recipients and a comprehensive analysis of specific risk factors are lacking. Methods. We analyzed the data of 313 patients in the Cooperative European Pediatric Renal Transplant Initiative Registry, with an observation period of 3.3 years (range, 1-5). The net state of immunosuppressive therapy was assessed by the modified Vasudev score. Results. Presumptive BKPyVAN (defined as sustained [>3 wk] high-level BK viremia >10(4) copies/mL) within 5 years posttransplant occurred in 49 (15.8%) of 311 patients, and biopsy-proven BKPyVAN in 14 (4.5%) of 313. BKPyV viremia was observed in 115 (36.7%) of 311 patients, of whom 11 (9.6%) of 115 developed viremia late, that is, after the second year posttransplant. In 6 (12.5%) of 48 patients with high-level viremia and in 3 (21.4%) of 14 with BKPyVAN, this respective event occurred late. According to multivariable analysis, BKPyV viremia and/or BKPyVAN were associated not only with a higher net state of immunosuppression (odds ratio [OR], 1.3; P < 0.01) and with tacrolimus-based versus ciclosporin-based immunosuppression (OR, 3.6; P < 0.01) but also with younger recipient age (OR, 1.1 per y younger; P < 0.001) and obstructive uropathy (OR, 12.4; P < 0.01) as primary renal disease. Conclusions. Uncontrolled BKPyV replication affects a significant proportion of pediatric renal transplant recipients and is associated with unique features of epidemiology and risk factors, such as young recipient age, obstructive uropathy, and overall intensity of immunosuppressive therapy. BKPyV surveillance should be considered beyond 2 years posttransplant in pediatric patients at higher risk

Selected properties of nuclei at the magic shell closures from the studies of E1, M1 and E2 transition rates

Using the Advanced Time-Delayed method we have studied transition rates in several neutron-rich nuclei at the magic shell closures. These include the heavy Co and Fe nuclei just below the Z=28 shell closure at the point of transition at N=37. A substantial increase in the information on this nucleus was obtained from a brief fast timing study conducted at ISOLDE. The new results indicate that 63Fe seems to depart from a simple shell model structure observed for heavier N=37 isotones of 65Ni and 67Zn. Another region of interest are the heavy Cd and Sn nuclei at N=72,74 and the properties of negative parity quasi-particle excitations. These experiments, performed at the IGISOL separator at Jyvaskyla, revealed interesting properties of the E2 rates in the sequence of E3 transitions connecting the 10+, 8+, 6+, 4+, 2+ and 0+ members of the multiplet of levels in 122Sn due to neutrons in the h11/2 orbit.status: publishe

Progress in understanding the role of hot electrons for the shock ignition approach to Inertial Confinement Fusion

This paper describes the results of a series of experiments conducted with the PALS laser at intensities of interest for the shock ignition approach to inertial fusion. In particular, we addressed the generation of hot electrons (determining their average energy and number), as well as the parametric instabilities which are producing them. In addition, we studied the impact of hot electrons on the formation and dynamics of strong shocks

Progress in understanding the role of hot electrons for the shock ignition approach to inertial confinement fusion

This paper describes the results of a series of experiments conducted with the PALS laser at intensities of interest for the shock ignition approach to inertial fusion. In particular, we addressed the generation of hot electrons (HE) (determining their average energy and number), as well as the parametric instabilities which are producing them. In addition, we studied the impact of HE on the formation and dynamics of strong shocks