Transverse instability due to the space charge during the electron-cooling bunching of ion beams

A beam-tracking simulation has been done for study of the electron- cooling bunching of ion beams around a few hundred MeV/u. In the simulation, the field due to the space charge of a beam in a round vacuum chamber is calculated from the charge distribution of macro- particles and the image particles due to the macro-particles. The simulation results show that the bunched beams meet a transverse instability more easily than coasting beams. (2 refs)

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal.

Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the Golgi. Norwalk virus nonstructural protein p22 contains a YXΦESDG motif that mimics a di-acidic ER export signal in both sequence and function. However, unlike normal ER export signals, the ER export signal mimic of p22 is necessary for apparent inhibition of normal COPII vesicle trafficking, which leads to Golgi disassembly and antagonism of Golgi-dependent cellular protein secretion. This is the first reported function for p22. Disassembly of the Golgi apparatus was also observed in cells replicating Norwalk virus, which may contribute to pathogenesis by interfering with cellular processes that are dependent on an intact secretory pathway. These results indicate that the ER export signal mimic is critical to the antagonistic function of p22, shown herein to be a novel antagonist of ER/Golgi trafficking. This unique and well-conserved human norovirus motif is therefore an appealing target for antiviral drug development

Control networks for the Galilean satellites, November 1979

Pictures of the four Galilean satellites taken as the two Voyager spacecraft approached Jupiter during March and July 1979 are presented. Control nets of the Galilean satellites, computed photogrammetrically, and measurements of the mean radii are presented. The pictures in the control nets are identified, the coordinates of the control points are given, and identifications of some of the control points are shown on figures. The use of star field pictures to compute the focal lengths of the camera is discussed and the geometric relationship between the narrow and wide and angle cameras is reported. A description of the coordinate systems of the Galilean satellites is presented and the status of the control net computations is reported

High stability design for new centrifugal compressor

It is essential that high-performance centrifugal compressors be free of subsynchronous vibrations. A new high-performance centrifugal compressor has been developed by applying the latest rotordynamics knowledge and design techniques: (1) To improve the system damping, a specially designed oil film seal was developed. This seal attained a damping ratio three times that of the conventional design. The oil film seal contains a special damper ring in the seal cartridge. (2) To reduce the destabilizing effect of the labyrinth seal, a special swirl canceler (anti-swirl nozzle) was applied to the balance piston seal. (3) To confirm the system damping margin, the dynamic simulation rotor model test and the full load test applied the vibration exciting test in actual load conditions