Design considerations for the use of laser-plasma accelerators for advanced space radiation studies

We present design considerations for the use of laser-plasma accelerators for mimicking space radiation and testing space-grade electronics. This novel application takes advantage of the inherent ability of laser-plasma accelerators to produce particle beams with exponential energy distribution, which is a characteristic shared with the hazardous relativistic electron flux present in the radiation belts of planets such as Earth, Saturn and Jupiter. Fundamental issues regarding laser-plasma interaction parameters, beam propagation, flux development, and experimental setup are discussed

Assessment of the effectiveness of head only and back-of-the-head electrical stunning of chickens

The study assesses the effectiveness of reversible head-only and back-of-the-head electrical stunning of chickens using 130–950 mA per bird at 50 Hz AC

On the toughness of thermoplastic polymer nanocomposites as assessed by the essential work of fracture (EWF) approach

The essential work of fracture (EWF) approach is widely used to determine the plane stress fracture toughness of highly ductile polymers and related systems. To shed light on how the toughness is affected by nanofillers EWF-suited model polymers, viz. amorphous copolyester and polypropylene block copolymer were modified by multiwall carbon nanotube (MWCNT), graphene (GR), boehmite alumina (BA), and organoclay (MMT) in 1 wt% each. EWF tests were performed on deeply double-edge notched tensile-loaded specimens under quasistatic loading conditions. Data reduction occurred by energy partitioning between yielding and necking/tearing. The EWF prerequisites were not met with the nanocomposites containing MWCNT and GR by contrast to those with MMT and BA. Accordingly, the toughness of nanocomposites with homogeneously dispersed and low aspect ratio fillers may be properly determined using the EWF. Results indicated that incorporation of nanofillers may result in an adverse effect between the specific essential and non-essential EWF parameters

Decremental All-Pairs ALL Shortest Paths and Betweenness Centrality

We consider the all pairs all shortest paths (APASP) problem, which maintains the shortest path dag rooted at every vertex in a directed graph G=(V,E) with positive edge weights. For this problem we present a decremental algorithm (that supports the deletion of a vertex, or weight increases on edges incident to a vertex). Our algorithm runs in amortized O(\vstar^2 \cdot \log n) time per update, where n=|V|, and \vstar bounds the number of edges that lie on shortest paths through any given vertex. Our APASP algorithm can be used for the decremental computation of betweenness centrality (BC), a graph parameter that is widely used in the analysis of large complex networks. No nontrivial decremental algorithm for either problem was known prior to our work. Our method is a generalization of the decremental algorithm of Demetrescu and Italiano [DI04] for unique shortest paths, and for graphs with \vstar =O(n), we match the bound in [DI04]. Thus for graphs with a constant number of shortest paths between any pair of vertices, our algorithm maintains APASP and BC scores in amortized time O(n^2 \log n) under decremental updates, regardless of the number of edges in the graph.Comment: An extended abstract of this paper will appear in Proc. ISAAC 201

3D printing-assisted interphase engineering of polymer composites: Concept and feasibility

We introduced a general concept to create smart, (multi)functional interphases in polymer composites with layered reinforcements, making use of 3D printing. The concept can be adapted for both thermoplastic and thermoset matrix-based composites with either thermoplastic- or thermoset-enriched interphases. We showed feasibility using an example of a composite containing a thermoset matrix/thermoplastic interphase. Carbon fiber unidirectional reinforcing layers were patterned with poly(ε-caprolactone) (PCL) through 3D printing, then infiltrated with an amine-cured epoxy (EP). The corresponding composites were subjected to static and dynamic flexure tests. The PCL-rich interphase markedly improved the ductility in static tests without deteriorating the flexural properties. Its effect was marginal in Charpy impact tests, which can be explained with effects of specimen and PCL pattern sizes. The PCL-rich interphase ensured self-healing when triggered by heat treatment above the melting temperature of PCL

Speeding up shortest path algorithms

Given an arbitrary, non-negatively weighted, directed graph $G=(V,E)$ we present an algorithm that computes all pairs shortest paths in time $\mathcal{O}(m^* n + m \lg n + nT_\psi(m^*, n))$, where $m^*$ is the number of different edges contained in shortest paths and $T_\psi(m^*, n)$ is a running time of an algorithm to solve a single-source shortest path problem (SSSP). This is a substantial improvement over a trivial $n$ times application of $\psi$ that runs in $\mathcal{O}(nT_\psi(m,n))$. In our algorithm we use $\psi$ as a black box and hence any improvement on $\psi$ results also in improvement of our algorithm. Furthermore, a combination of our method, Johnson's reweighting technique and topological sorting results in an $\mathcal{O}(m^*n + m \lg n)$ all-pairs shortest path algorithm for arbitrarily-weighted directed acyclic graphs. In addition, we also point out a connection between the complexity of a certain sorting problem defined on shortest paths and SSSP.Comment: 10 page

Association Between Homocysteine and Vascular Calcification Incidence, Prevalence, and Progression in the MESA Cohort.

Background While elevated homocysteine has been associated with calcification in several studies, its importance as a cardiovascular risk factor remains unclear. This study examines the relationship between homocysteine and vascular and valve calcification in the MESA (Multi-ethnic Study of Atherosclerosis) cohort. Methods and Results MESA participants with baseline homocysteine measurements and cardiac computed tomography scans were included (N=6789). Baseline and follow-up assessment of vascular (coronary artery [CAC], descending thoracic aorta [DTAC]) and valve (aortic valve [AVC], mitral annular [MAC]) calcification was performed. Prevalence ratio/relative risk regression was used to assess the relationship of homocysteine with prevalent and incident calcification, and multivariable logistic regression was used to assess associations between homocysteine and calcification progression. Elevated homocysteine was associated with greater relative risk of prevalent and incident CAC and incident DTAC. We also identified a strong association between elevated homocysteine and CAC and DTAC progression. Elevated homocysteine was found to confer a >2-fold increased risk of severe CAC progression (defined as ΔCAC ≥100/year) and an ≈1.5-fold increased risk for severe DTAC progression (defined as ΔDTAC ≥100/year). Conclusions To our knowledge, this is the first study demonstrating an association between elevated homocysteine and both incidence and progression of coronary and extra-coronary vascular calcification. Our findings suggest a potential role for elevated homocysteine as a risk factor for severe vascular calcification progression. Future studies are warranted to further assess the utility of homocysteine as a biomarker for vascular calcification incidence and progression. Clinical Trial Registration https://www.clinicaltrials.gov/. Unique identifier: NCT00005487

A short history of the first 3 years of the Community Genetics Network and its newsletter

When in 2007 it became clear that the Karger journal Community Genetics would change its name and scope, the first author started to establish an international, multidisciplinary e-mail network and a newsletter with papers authored by the members of the network. This paper reports on the first 3 years of the network. At the end of the 3-year period, there were 858 members, 50 newsletters had appeared, and almost 1,500 different papers from 458 journals had been cited. This model may serve as an example for others who want to bring together those sharing a common interest