66 research outputs found

    Photonuclear reactions with Zinc: A case for clinical linacs

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    The use of bremsstrahlung photons produced by a linac to induce photonuclear reactions is wide spread. However, using a clinical linac to produce the photons is a new concept. We aimed to induce photonuclear reactions on zinc isotopes and measure the subsequent transition energies and half-lives. For this purpose, a bremsstrahlung photon beam of 18 MeV endpoint energy produced by the Philips SLI-25 linac has been used. The subsequent decay has been measured with a well-shielded single HPGe detector. The results obtained for transition energies are in good agreement with the literature data and in many cases surpass these in accuracy. For the half-lives, we are in agreement with the literature data, but do not achieve their precision. The obtained accuracy for the transition energies show what is achievable in an experiment such as ours. We demonstrate the usefulness and benefits of employing clinical linacs for nuclear physics experiments

    The qualitative transparency deliberations: insights and implications

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    In recent years, a variety of efforts have been made in political science to enable, encourage, or require scholars to be more open and explicit about the bases of their empirical claims and, in turn, make those claims more readily evaluable by others. While qualitative scholars have long taken an interest in making their research open, reflexive, and systematic, the recent push for overarching transparency norms and requirements has provoked serious concern within qualitative research communities and raised fundamental questions about the meaning, value, costs, and intellectual relevance of transparency for qualitative inquiry. In this Perspectives Reflection, we crystallize the central findings of a three-year deliberative process—the Qualitative Transparency Deliberations (QTD)—involving hundreds of political scientists in a broad discussion of these issues. Following an overview of the process and the key insights that emerged, we present summaries of the QTD Working Groups’ final reports. Drawing on a series of public, online conversations that unfolded at www.qualtd.net, the reports unpack transparency’s promise, practicalities, risks, and limitations in relation to different qualitative methodologies, forms of evidence, and research contexts. Taken as a whole, these reports—the full versions of which can be found in the Supplementary Materials—offer practical guidance to scholars designing and implementing qualitative research, and to editors, reviewers, and funders seeking to develop criteria of evaluation that are appropriate—as understood by relevant research communities—to the forms of inquiry being assessed. We dedicate this Reflection to the memory of our coauthor and QTD working group leader Kendra Koivu

    Childhood trauma, life-time self-harm, and suicidal behaviour and ideation are associated with polygenic scores for autism

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    Abstract: Autistic individuals experience significantly elevated rates of childhood trauma, self-harm and suicidal behaviour and ideation (SSBI). Is this purely the result of negative environmental experiences, or does this interact with genetic predisposition? In this study we investigated if a genetic predisposition for autism is associated with childhood trauma using polygenic scores (PGS) and genetic correlations in the UK Biobank (105,222 < N < 105,638), and tested potential mediators and moderators of the association between autism, childhood trauma and SSBI. Autism PGS were significantly associated with childhood trauma (max R2 = 0.096%, P < 2 × 10−16), self-harm ideation (max R2 = 0.108%, P < 2 × 10−16), and self-harm (max R2 = 0.13%, P < 2 × 10−16). Supporting this, we identified significant genetic correlations between autism and childhood trauma (rg = 0.36 ± 0.05, P = 8.13 × 10−11), self-harm ideation (rg = 0.49 ± 0.05, P = 4.17 × 10−21) and self-harm (rg = 0.48 ± 0.05, P = 4.58 × 10−21), and an over-transmission of PGS for the two SSBI phenotypes from parents to autistic probands. Male sex negatively moderated the effect of autism PGS on childhood trauma (β = −0.023 ± 0.005, P = 6.74 × 10−5). Further, childhood trauma positively moderated the effect of autism PGS on self-harm score (β = 8.37 × 10−3 ± 2.76 × 10−3, P = 2.42 × 10−3) and self-harm ideation (β = 7.47 × 10−3 ± 2.76 × 10−3, P = 6.71 × 10−3). Finally, depressive symptoms, quality and frequency of social interactions, and educational attainment were significant mediators of the effect of autism PGS on SSBI, with the proportion of effect mediated ranging from 0.23 (95% CI: 0.09–0.32) for depression to 0.008 (95% CI: 0.004–0.01) for educational attainment. Our findings identify that a genetic predisposition for autism is associated with adverse life-time outcomes, which represent complex gene-environment interactions, and prioritizes potential mediators and moderators of this shared biology. It is important to identify sources of trauma for autistic individuals in order to reduce their occurrence and impact

    II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies

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    Modeling of wind turbine systems and analyses of their output characteristics on distribution systems with voltage/frequency dependent static loads (Part II: Modeling and simulation of wind turbine systems) [Rüzgâr türbini sistemlerinin modellenmesi ve farkli gerilim/frekans bagimli statik yüklü dagitim sistemlerinde çikiş karakteristiginin i·ncelenmesi (Bölüm II: Rüzgâr türbini sistemlerinin modellenmesi ve simülasyonu)]

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    2010 7th National Conference on Electrical, Electronics and Computer Engineering, ELECO 2010 -- 2 December 2010 through 5 December 2010 -- Bursa -- 83834In this paper, the effects of static loads on the output characteristics of Wind Turbine Systems are analyzed. For this purpose, Simulink realization of Wind Turbine Systems is provided by using Matlab/Simulink SimPowerSystems Blockset and simulated in a test system with voltage/frequency dependent static loads, which are also modelled in Matlab/Simulink. It is observed from simulations that a Wind Turbine Systems connected to a system experiences frequency deviation will exhibit different voltage and output power characteristics for different static load types

    ARDYANMALI VE AYRIK AKIŞLI TURBOFANLARDA FAN BASINÇ ORANI VE BYPASS ORANIYLA TOPLAM VERİMİN DEĞİŞİMİNİN İNCELENMESİ

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    Overall efficiency is an important design parameter of the engine in preliminary design and defined as the ratio of aircraft thrust power to the rate of thermal energy released in the engine. In this paper, effects of the fan pressure ratio and the bypass ratio on engine overall efficiency were investigated for afterburning and separate flow turbofans. With this purpose, fan pressure ratio⎯bypass ratio⎯overall efficiency three dimensional graphs were developed and then computer experiment results were evaluated for three different flight Mach number
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