High and Low Dimensions in The Black Hole Negative Mode

The negative mode of the Schwarzschild black hole is central to Euclidean quantum gravity around hot flat space and for the Gregory-Laflamme black string instability. We analyze the eigenvalue as a function of space-time dimension by constructing two perturbative expansions: one for large d and the other for small d-3, and determining as many coefficients as we are able to compute analytically. Joining the two expansions we obtain an interpolating rational function accurate to better than 2% through the whole range of dimensions including d=4.Comment: 17 pages, 4 figures. v2: added reference. v3: published versio

Comparing the benefits of parent-infant flute and singing groups for communication and parenting: A feasibility study

There is growing evidence highlighting benefits of musical exposure and participation on several aspects of development and parenting. Aiming to establish a rigorous protocol allowing researchers to study different types of musical interactions and their benefits on the development of early communication, the present study explored parents’ experiences of musically engaging with their infants in different types of music groups. Twenty-five infants and their parents were randomly assigned to one of three groups: (1) singing, (2) flute playing or (3) control group. Music sessions were held weekly for 14 weeks and were followed by the home use of the recorded routines specific of each group, for further three months. Semi structured interviews were conducted with the experimental groups’ participants, and pre/post quantitative developmental measures were collected from all groups, to assess participants’ compliance. Qualitative analyses of the interviews revealed both shared themes, (communication enhancement, enjoyment and regulation); and unique themes (creativity and freedom in the flute group; familiarity and responsiveness in the singing group). The feasibility study was successful in establishing a workable protocol to use in RCT longitudinal interventions aiming to examine how specific aspects of the musical experience might differentially support developmental outcomes, in parent-infant groups

The soundscape of neonatal intensive care: a mixed-methods study of the parents’ experience

Parents who have infants hospitalised in neonatal intensive care units (NICUs) experience high levels of stress, including post-traumatic stress disorder (PTSD) symptoms. However, whether sounds contribute to parents’ stress remains largely unknown. Critically, researchers lack a com-prehensive instrument to investigate the relationship between sounds in NICUs and parental stress. To address this gap, this report presents the “Soundscape of NICU Questionnaire” (SON-Q), which was developed specifically to capture parents’ perceptions and beliefs about the impact that sound had on them and their infants, from pre-birth throughout the NICU stay and in the first postdischarge period. Parents of children born preterm (n = 386) completed the SON-Q and the Perinatal PTSD Questionnaire (PPQ). Principal Component Analysis identifying underly-ing dimensions comprising the parental experience of the NICU soundscape was followed by an exploration of the relationships between subscales of the SON-Q and the PPQ. Moderation analy-sis was carried out to further elucidate relationships between variables. Finally, thematic analy-sis was employed to analyse one memory of sounds in NICU open question. The results highlight systematic associations between aspects of the NICU soundscape and parental stress/trauma. The findings underscore the importance of developing specific studies in this area and devising inter-ventions to best support parents’ mental health, which could in turn support infants’ develop-mental outcomes

Kondo Effect in Defect-bound Quantum Dots Coupled to NbSe2_2

We report the fabrication of a van der Waals tunneling device hosting a defect-bound quantum dot coupled to NbSe$_2$. We find that upon application of magnetic field, the device exhibits a zero-bias conductance peak. The peak, which splits at higher fields, is associated with a Kondo effect. At the same time, the junction retains conventional quasiparticle tunneling features at finite bias. Such coexistence of a superconducting gap and a Kondo effect are unusual, and are explained by noting the two-gap nature of the superconducting state of NbSe$_2$, where a magnetic field suppresses the low energy gap associated with the Se band. Our data shows that van der Waals architectures, and defect-bound dots in them, can serve as a novel and effective platform for investigating the interplay of Kondo screening and superconducting pairing in unconventional superconductors

Global Journalist: GJ talks lessons learned by foreign journalists at MU Journalism Program

This May 15, 2003 program of Global Journalist featured guest host Byron Scott speaking with three international journalists who spent the last year learning about American media at the Missouri School of Journalism through the Humphrey Fellowship Program. Host: Byron Scott. Guests: Rosia Cattell, Milena diMitrova, Rashid Hadar. Producers: Jeff Stone. Directors: Mary Fornesa

Revisiting Politicide: State Annihilation in Israel/Palestine

State annihilation is a persistent concern in Israel/Palestine. While the specter of Israel’s destruction increasingly haunts Israeli public political debates, the actual materialization of Palestinian statehood seems to be permanently suspended, caught in an ever-protracted process of state-building. The current paper claims that to understand the unfolding of the discursive formations, as well as the spatial dimensions of conflict and control in Israel/Palestine, we should explicate the workings of the processes of politicide. Politicide, in this regard, denotes the eradication of the political existence of a group and sabotaging the turning of a community of people into a polity. This analysis suggests that the insistence that the State of Israel is under threat of extinction should be understood as a speech act, a performative reiteration, which allows for the securitization of Israeli rule in the occupied Palestinian territory, a securitization which then serves to rationalize the ongoing concrete politicide of the Palestinians. Elaborating on the concept of politicide, and diverging from defining it solely through the use of brute violence, this examination suggests that what is often overlooked in discussions of politicide are the seemingly more benign means of its implementation, the micro-power mechanisms of spatial control, prohibitions and regulations

SPRING: an RCT study of probiotics in the prevention of gestational diabetes mellitus in overweight and obese women

Background: Obesity is increasing in the child-bearing population as are the rates of gestational diabetes. Gestational diabetes is associated with higher rates of Cesarean Section for the mother and increased risks of macrosomia, higher body fat mass, respiratory distress and hypoglycemia for the infant. Prevention of gestational diabetes through life style intervention has proven to be difficult. A Finnish study showed that ingestion of specific probiotics altered the composition of the gut microbiome and thereby metabolism from early gestation and decreased rates of gestational diabetes in normal weight women. In SPRING (the Study of Probiotics IN the prevention of Gestational diabetes), the effectiveness of probiotics ingestion for the prevention of gestational diabetes will be assessed in overweight and obese women

EZH2 promotes a bi-lineage identity in basal-like breast cancer cells

The mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like breast carcinomas. Here we show that the Polycomb factor EZH2 maintains the differentiation state of basal-like breast cancer cells, and promotes the expression of progenitor-associated and basal-lineage genes. Specifically, EZH2 regulates the composition of basal-like breast cancer cell populations by promoting a ‘bi-lineage’ differentiation state, in which cells co-express basal- and luminal-lineage markers. We show that human basal-like breast cancers contain a subpopulation of bi-lineage cells, and that EZH2-deficient cells give rise to tumors with a decreased proportion of such cells. Bi-lineage cells express genes that are active in normal luminal progenitors, and possess increased colony-formation capacity, consistent with a primitive differentiation state. We found that GATA3, a driver of luminal differentiation, performs a function opposite to EZH2, acting to suppress bi-lineage identity and luminal-progenitor gene expression. GATA3 levels increase upon EZH2 silencing, mediating a decrease in bi-lineage cell numbers. Our findings reveal a novel role for EZH2 in controlling basal-like breast cancer differentiation state and intra-tumoral cell composition

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2]. Using a metabolomics approach with isotope labeling, we found that in some cancer cells a relatively large amount of glycolytic carbon is diverted into serine and glycine metabolism through phosphoglycerate dehydrogenase (PHGDH). An analysis of human cancers showed that PHGDH is recurrently amplified in a genomic region of focal copy number gain most commonly found in melanoma. Decreasing PHGDH expression impaired proliferation in amplified cell lines. Increased expression was also associated with breast cancer subtypes, and ectopic expression of PHGDH in mammary epithelial cells disrupted acinar morphogenesis and induced other phenotypic alterations that may predispose cells to transformation. Our findings show that the diversion of glycolytic flux into a specific alternate pathway can be selected during tumor development and may contribute to the pathogenesis of human cancer.National Institutes of Health (U.S.)National Cancer Institute (U.S.)Smith Family FoundationDamon Runyon Cancer Research FoundationBurroughs Wellcome Fun

Music with displaced dyads: Ukrainian parents’ perspectives on a music therapy group

The war in Ukraine has caused a major humanitarian crisis, compelling many citizens, particularly children, to flee and seek refuge in other nations. Numerous studies have highlighted the significant impact of parenting practices in either mitigating or exacerbating the effects of mass trauma on children’s ability to adapt. Particularly, music therapy has shown promise in addressing trauma and displacement, with multiple studies demonstrating its potential benefits. The current study explores the experience of parent-child dyads displaced from Ukraine (as perceived by parent-participants and group-leader), who took part in an eight-week music therapy group intervention. The project sought to create effective protocols in collaboration with the displaced community. The current work focuses on the qualitative aspect of the project. Semi-structured interviews were conducted both with the parent-participants as well as with the music therapy group-leader. A thematic analysis of all data revealed four central themes: (A) The music space as a safe haven; (B) A gentle, attuned approach enabling parental leadership; (C) Emerging group cohesion and community; and (D) Music as a catalyst for developmental change. This study highlights how structured, trauma-informed music therapy facilitates emotional regulation and resilience in displaced parent-child dyads by integrating predictable musical routines with improvisational play. Through co-regulation, shared musical engagement, and the creation of a safe, attuned group environment, music emerged as a powerful medium for fostering connection, empowerment, and developmental recovery in the aftermath of trauma