Digital simulation and experimental evaluation of the CO2-H(plus) control of pulmonary ventilation

Previous models of the CO2-H(+) control of ventilation have been concerned either with the response to CO2 inhalation, or the response to perfusion of the surface of the medulla with mock cerebrospinal fluid having a high P sub CO2. Simulation of both responses with the same model has not been attempted. The purpose of the present study was two fold; first to develop such a model and, second, to obtain experimental data from human subjects for both developing this model and for evaluating this and future models

Complete recovery from anxiety disorders following Cognitive Behavioural Therapy in children and adolescents: a meta analysis

Cognitive Behavior Therapy (CBT) is a well-established treatment for childhood anxiety disorders. Meta-analyses have concluded that approximately 60% of children recover following treatment, however these include studies using a broad range of diagnostic indices to assess outcomes including whether children are free of the one anxiety disorder that causes most interference (i.e. the primary anxiety disorder) or whether children are free of all anxiety disorders. We conducted a meta-analysis to establish the efficacy of CBT in terms of absence of all anxiety disorders. Where available we compared this rate to outcomes based on absence of primary disorder. Of 56 published randomized controlled trials, 19 provided data on recovery from all anxiety disorders (n = 635 CBT, n = 450 control participants). There was significant heterogeneity across those studies with available data and full recovery rates varied from 47.6 to 66.4% among children without autistic spectrum conditions (ASC) and 12.2 to 36.7% for children with ASC following treatment, compared to up to 20.6% and 21.3% recovery in waitlist and active treatment comparisons. The lack of consistency in diagnostic outcomes highlights the urgent need for consensus on reporting in future RCTs of childhood anxiety disorders for the meaningful synthesis of data going forwards

WHAM Observations of H-alpha Emission from High Velocity Clouds in the M, A, and C Complexes

The first observations of the recently completed Wisconsin H-Alpha Mapper (WHAM) facility include a study of emission lines from high velocity clouds in the M, A, and C complexes, with most of the observations on the M I cloud. We present results including clear detections of H-alpha emission from all three complexes with intensities ranging from 0.06 R to 0.20 R. In every observed direction where there is significant high velocity H I gas seen in the 21 cm line we have found associated ionized hydrogen emitting the H-alpha line. The velocities of the H-alpha and 21 cm emission are well correlated in every case except one, but the intensities are not correlated. There is some evidence that the ionized gas producing the H-alpha emission envelopes the 21 cm emitting neutral gas but the H-alpha "halo", if present, is not large. If the H-alpha emission arises from the photoionization of the H I clouds, then the implied Lyman continuum flux F_{LC} at the location of the clouds ranges from 1.3 to 4.2 x 10^5 photons cm^{-2} s^{-1}. If, on the other hand, the ionization is due to a shock arising from the collision of the high-velocity gas with an ambient medium in the halo, then the density of the pre-shocked gas can be constrained. We have also detected the [S II] 6716 angstrom line from the M I cloud and have evidence that the [S II] to H-alpha ratio varies with location on the cloud.Comment: 32 pages, 18 figures, to appear in ApJ (Sept. 10, 1998

On The Reddening in X-ray Absorbed Seyfert 1 Galaxies

There are several Seyfert galaxies for which there is a discrepancy between the small column of neutral hydrogen deduced from X-ray observations and the much greater column derived from the reddening of the optical/UV emission lines and continuum. The standard paradigm has the dust within the highly ionized gas which produces O~VII and O~VIII absorption edges (i.e., a ``dusty warm absorber''). We present an alternative model in which the dust exists in a component of gas in which hydrogen has been stripped, but which is at too low an ionization state to possess significant columns of O~VII and O~VIII (i.e, a ``lukewarm absorber''). The lukewarm absorber is at sufficient radial distance to encompass much of the narrow emission-line region, and thus accounts for the narrow-line reddening, unlike the dusty warm absorber. We test the model by using a combination of photoionization models and absorption edge fits to analyze the combined ROSAT/ASCA dataset for the Seyfert 1.5 galaxy, NGC 3227. We show that the data are well fit by a combination of the lukewarm absorber and a more highly ionized component similar to that suggested in earlier studies. We predict that the lukewarm absorber will produce strong UV absorption lines of N V, C IV, Si IV and Mg II. Finally, these results illustrate that singly ionized helium is an important, and often overlooked, source of opacity in the soft X-ray band (100 - 500 eV).Comment: 17 pages, Latex, includes 1 figure (encapsulated postscript), one additional table in Latex (landscape format), to appear in the Astrophysical Journa

Searching and fixating: scale-invariance vs. characteristic timescales in attentional processes

In an experiment involving semantic search, the visual movements of sample populations subjected to visual and aural input were tracked in a taskless paradigm. The probability distributions of saccades and fixations were obtained and analyzed. Scale-invariance was observed in the saccadic distributions, while the fixation distributions revealed the presence of a characteristic (attentional) time scale for literate subjects. A detailed analysis of our results suggests that saccadic eye motions are an example of Levy, rather than Brownian, dynamics.Comment: Accepted to Europhysics Letters (2011

The heritability of methyl anthranilate and total volatile esters in Vitis spp. hybrids

Two grapevine seedlings, V. 72181 and V. 72182, selected for extremely high methyl anthranilate (MA) and total volatile esters (TVE) content, were selfed to create families 8020 and 8021 respectively, to test the inheritance of these two components of labrusca flavour character. REYNOLDS et al. (1982) had postulated a three-gene, dominant and complementary system (M, A, F) for MA and a two-gene dominant and complementary system (T, V) for TVE. Families 8020 and 8021 segregated 3:1 for MA, indicating only one heterozygous locus for MA in the parents. This would question REYNOLDS' assignment of genotypes for the grandparents of these two families and would suggest a more complex environmentally influenced system. The TVE segregation patterns followed REYNOLDS' hypothesis and segregated 3:1 for one heterozygous locus

The variable OVIII Warm Absorber in MCG-6-30-15

We present the results of a 4 day ASCA observation of the Seyfert galaxy MCG-6-30-15, focussing on the nature of the X-ray absorption by the warm absorber, characterizd by the K-edges of the intermediately ionized oxygen, OVII and OVIII. We confirm that the column density of OVIII changes on a timescale of $\sim 10^4$~s when the X-ray continuum flux decreases. The significant anti-correlation of column density with continuum flux gives direct evidence that the warm absorber is photoionized by the X-ray continuum. From the timescale of the variation of the OVIII column density, we estimate that it originates from gas within a radius of about 10^{17}\cm of the central engine. In contrast, the depth of the OVII edge shows no response to the continuum flux, which indicates that it originates in gas at larger radii. Our results strongly suggest that there are two warm absorbing regions; one located near or within the Broad Line Region, the other associated with the outer molecular torus, scattering medium or Narrow Line Region.Comment: 8 pages (including figures) uuencoded gziped PS file. Submitted to Publications of the Astronomical Society of Japa

The high energy gamma-ray emission expected from Tycho's supernova remnant

A nonlinear kinetic model of cosmic ray (CR) acceleration in supernova remnants (SNRs) is used to describe the properties of Tycho's SNR. Observations of the expansion characteristics and of the nonthermal radio and X-ray emission spectra, assumed to be of synchrotron origin, are used to constrain the overall dynamical evolution and the particle acceleration parameters of the system, in addition to what is known from independent estimates of the distance and thermal X-ray observations. It is shown that a very efficient production of nuclear cosmic rays, leading to strong shock modification, and a large downstream magnetic field strength B_d approx 240muG are required to reproduce the observed synchrotron emission from radio to X-ray frequencies. This field strength is still well within the upper bound for the effective magnetic field, consistent with the acceleration process. The pi^0-decay gamma-ray flux turns out to be somewhat greater than the inverse Compton (IC) flux off the Cosmic Microwave Background at energies below 1 TeV, dominating it strongly at 10 TeV. The predicted TeV gamma-ray flux is consistent with but close to the very low upper limit recently obtained by HEGRA. A future detection at E_gamma ~ 10 TeV would clearly indicate hadronic emission.Comment: 8 pages, 6 figures. Accepted in Astronomy and Astrophyic

The synthesis and purification of aromatic hydrocarbons IV : 1,2,3-trimethylbenzene

A six gallon quantity of 1,2,3-trimethylbenezene was prepared and purified in a four-step synthesis involving the condensation of 1,3-pentadiene with crotonaldehyde. The dimethylcyclohexencarboxaldehydes formed were hydrogenated to give the corresponding isomeric dimethylcyclohexylcarbinols. The dehydration of the carbinols and the subsequent dehydrogenation of the trimethylcyclohexenes yielded the 1,2,3-trimethylbenzene. The overall yield was 24 percent; the physical properties of the materials are given