On the interpretation of results from small punch creep tests

The small punch creep testing method is highly complex and involves interactions between a number of non-linear processes. The deformed shapes that are produced from such tests are related to the punch and specimen dimensions and to the elastic, plastic, and creep behaviour of the test material, under contact and large deformation conditions, at elevated temperature. Owing to its complex nature, it is difficult to interpret the small punch test creep data in relation to the corresponding uniaxial creep behaviour of the material. One of the aims of this paper is to identify the important characteristics of the creep deformation resulting from ‘localized’ deformations and from the ‘overall’ deformation of the specimen. Following this, the results of approximate analytical and detailed finite element analyses of small punch tests are investigated. It is shown that the regions of the uniaxial creep test curves dominated by primary, secondary, and tertiary creep are not those that are immediately apparent from the displacement versus time records produced during a small punch test. On the basis of the interpretation of the finite element results presented, a method based on a reference stress approach is proposed for interpreting the results of small punch test experimental data. Future work planned for the interpretation of small punch tests data is briefly addressed

Detection of human influence on a new, validated 1500-Year temperature reconstruction

Climate records over the last millennium place the twentieth-century warming in a longer historical context. Reconstructions of millennial temperatures show a wide range of variability, raising questions about the reliability of currently available reconstruction techniques and the uniqueness of late-twentieth-century warming. A calibration method is suggested that avoids the loss of low-frequency variance. A new reconstruction using this method shows substantial variability over the last 1500 yr. This record is consistent with independent temperature change estimates from borehole geothermal records, compared over the same spatial and temporal domain. The record is also broadly consistent with other recent reconstructions that attempt to fully recover low-frequency climate variability in their central estimate. High variability in reconstructions does not hamper the detection of greenhouse gas-induced climate change, since a substantial fraction of the variance in these reconstructions from the beginning of the analysis in the late thirteenth century to the end of the records can be attributed to external forcing. Results from a detection and attribution analysis show that greenhouse warming is detectable in all analyzed high-variance reconstructions (with the possible exception of one ending in 1925), and that about a third of the warming in the first half of the twentieth century can be attributed to anthropogenic greenhouse gas emissions. The estimated magnitude of the anthropogenic signal is consistent with most of the warming in the second half of the twentieth century being anthropogenic

Dispersion Relations for Thermally Excited Waves in Plasma Crystals

Thermally excited waves in a Plasma crystal were numerically simulated using a Box_Tree code. The code is a Barnes_Hut tree code proven effective in modeling systems composed of large numbers of particles. Interaction between individual particles was assumed to conform to a Yukawa potential. Particle charge, mass, density, Debye length and output data intervals are all adjustable parameters in the code. Employing a Fourier transform on the output data, dispersion relations for both longitudinal and transverse wave modes were determined. These were compared with the dispersion relations obtained from experiment as well as a theory based on a harmonic approximation to the potential. They were found to agree over a range of 0.9<k<5, where k is the shielding parameter, defined by the ratio between interparticle distance a and dust Debye length lD. This is an improvement over experimental data as current experiments can only verify the theory up to k = 1.5.Comment: 8 pages, Presented at COSPAR '0

Determination of material properties in the Chaboche unified viscoplasticity model

An experimental programme of cyclic mechanical testing of a 316 stainless steel, at temperatures up to 600°C, under isothermal conditions, for the identification of material constitutive constants, has been carried out using a thermo-mechanical fatigue (TMF) test machine with induction coil heating. The constitutive model adopted is a modified Chaboche unified viscoplasticity model, which can deal with both cyclic effects, such as combined isotropic and kinematic hardening, and rate-dependent effects, associated with viscoplasticity. The characterization of 316 stainless steel is presented and compared with results from cyclic isothermal tests. A least-squares optimization algorithm has been developed and implemented for determining the material constants in order to further improve the general fit of the model to experimental data, using the initially obtained material constants as the starting point in this optimization process. The model predictions using both the initial and optimized material constants are compared to experimental data

Hybrid architecture active wavefront sensing and control system, and method

According to various embodiments, provided herein is an optical system and method that can be configured to perform image analysis. The optical system can comprise a telescope assembly and one or more hybrid instruments. The one or more hybrid instruments can be configured to receive image data from the telescope assembly and perform a fine guidance operation and a wavefront sensing operation, simultaneously, on the image data received from the telescope assembly

Use of small specimen creep data in component life management: a review

Small specimen creep testing techniques are novel mechanical test techniques that have been developed over the past 25 years. They mainly include the sub-size uniaxial test, the small punch creep test, the impression creep test, the small ring creep test and the two-bar creep test. This paper outlines the current methods in practice for data interpretation as well as the state-of-the-art procedures for conducting the tests. Case studies for the use of impression creep testing and material strength ranking of creep resistant steels are reviewed along with the requirement for the standardisation of the impression creep test method. A database of small specimen creep testing is required to prove the validity of the tests

A basis for selecting the most appropriate small specimen creep test type

Many components in conventional and nuclear power plant, aero-engines, chemical plant etc., operate at temperatures which are high enough for creep to occur. These include plain pipes, pipe bends, branched pipes etc., the manufacture of such components may also require welds to be inserted in them. In most cases, only nominal operating conditions (i.e., pressure, temperatures, system load, etc.) are known and hence precise life predictions are not possible. Also, the proportion of life consumed will vary from position to position within a component and the plant. Hence, nondestructive techniques are adopted to assist in making decisions on whether to repair, continue operating or scrap certain components. One such approach is to use scoop samples removed from the components to make small creep test specimens, i.e., sub-size uniaxial creep test specimens, impression creep test specimens, small punch creep test specimens, and small ring (circular or elliptical) creep test specimens. Each specimen type has its own unique advantages and disadvantages and it may not be obvious which one is the most appropriate test method to use. This paper gives a brief description of each specimen and associated test type and describes their practical limitations. The suitability of each of the methods for determining “bulk” material properties is described and it is shown that an appropriate test type can be chosen

Finite element thermal analysis of the fusion welding of a P92 steel pipe

Fusion welding is common in steel pipeline construction in fossil-fuel power generation plants. Steel pipes in service carry steam at high temperature and pressure, undergoing creep during years of service; their integrity is critical for the safe operation of a plant. The high-grade martensitic P92 steel is suitable for plant pipes for its enhanced creep strength. P92 steel pipes are usually joined together with a similar weld metal. Martensitic pipes are sometimes joined to austenitic steel pipes using nickel based weld consumables. Welding involves severe thermal cycles, inducing residual stresses in the welded structure, which, without post weld heat treatment (PWHT), can be detrimental to the integrity of the pipes. Welding residual stresses can be numerically simulated by applying the finite element (FE) method in Abaqus. The simulation consists of a thermal analysis, determining the temperature history of the FE model, followed by a sequentially-coupled structural analysis, predicting residual stresses from the temperature history. &lt;br&gt;&lt;br&gt; In this paper, the FE thermal analysis of the arc welding of a typical P92 pipe is presented. The two parts of the P92 steel pipe are joined together using a dissimilar material, made of Inconel weld consumables, producing a multi-pass butt weld from 36 circumferential weld beads. Following the generation of the FE model, the FE mesh is controlled using Model Change in Abaqus to activate the weld elements for each bead at a time corresponding to weld deposition. The thermal analysis is simulated by applying a distributed heat flux to the model, the accuracy of which is judged by considering the fusion zones in both the parent pipe as well as the deposited weld metal. For realistic fusion zones, the heat flux must be prescribed in the deposited weld pass and also the adjacent pipe elements. The FE thermal results are validated by comparing experimental temperatures measured by five thermocouples on the pipe outside surface with the FE temperature history at corresponding nodal points

A model-based assessment of the cost-utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients.

This is a freely-available open access publication. Please cite the published version which is available via the DOI link in this record.BACKGROUND: Lynch syndrome is an autosomal dominant cancer predisposition syndrome caused by mutations in the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2. Individuals with Lynch syndrome have an increased risk of colorectal cancer, endometrial cancer, ovarian and other cancers. Lynch syndrome remains underdiagnosed in the UK. Reflex testing for Lynch syndrome in early-onset colorectal cancer patients is proposed as a method to identify more families affected by Lynch syndrome and offer surveillance to reduce cancer risks, although cost-effectiveness is viewed as a barrier to implementation. The objective of this project was to estimate the cost-utility of strategies to identify Lynch syndrome in individuals with early-onset colorectal cancer in the NHS. METHODS: A decision analytic model was developed which simulated diagnostic and long-term outcomes over a lifetime horizon for colorectal cancer patients with and without Lynch syndrome and for relatives of those patients. Nine diagnostic strategies were modelled which included microsatellite instability (MSI) testing, immunohistochemistry (IHC), BRAF mutation testing (methylation testing in a scenario analysis), diagnostic mutation testing and Amsterdam II criteria. Biennial colonoscopic surveillance was included for individuals diagnosed with Lynch syndrome and accepting surveillance. Prophylactic hysterectomy with bilateral salpingo-oophorectomy (H-BSO) was similarly included for women diagnosed with Lynch syndrome. Costs from NHS and Personal Social Services perspective and quality-adjusted life years (QALYs) were estimated and discounted at 3.5% per annum. RESULTS: All strategies included for the identification of Lynch syndrome were cost-effective versus no testing. The strategy with the greatest net health benefit was MSI followed by BRAF followed by diagnostic genetic testing, costing £5,491 per QALY gained over no testing. The effect of prophylactic H-BSO on health-related quality of life (HRQoL) is uncertain and could outweigh the health benefits of testing, resulting in overall QALY loss. CONCLUSIONS: Reflex testing for Lynch syndrome in early-onset colorectal cancer patients is predicted to be a cost-effective use of limited financial resources in England and Wales. Research is recommended into the cost-effectiveness of reflex testing for Lynch syndrome in other associated cancers and into the impact of prophylactic H-BSO on HRQoL.NIH

A systematic review and economic evaluation of intraoperative tests [RD-100i one-step nucleic acid amplification (OSNA) system and Metasin test] for detecting sentinel lymph node metastases in breast cancer.

This is the final version of the review. Available from NIHR via the DOI in this record.BACKGROUND: In breast cancer patients, sentinel lymph node biopsy is carried out at the same time as the removal of the primary tumour to postoperatively test with histopathology for regional metastases in the sentinel lymph node. Those patients with positive test results are then operated on 2-4 weeks after primary surgery to remove the lymph nodes from the axilla (axillary lymph node dissection, ALND). New molecular tests RD-100i [one-step nucleic acid amplification (OSNA); based on messenger RNA amplification to identify the cytokeratin-19 (CK19) gene marker] (Sysmex, Norderstedt, Germany) and Metasin (using the CK19 and mammaglobin gene markers) (Cellular Pathology, Princess Alexandra Hospital NHS Trust, Harlow, UK) are intended to provide an intraoperative diagnosis, thereby avoiding the need for postoperative histopathology and, in positive cases, a second operation for ALND. OBJECTIVE: To evaluate the clinical effectiveness and cost-effectiveness of using OSNA and Metasin in the NHS in England for the intraoperative diagnosis of sentinel lymph nodes metastases, compared with postoperative histopathology, the current standard. DATA SOURCES: Electronic databases including MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, The Cochrane Library and the Health Economic Evaluations Database as well as clinical trial registries, grey literature and conference proceedings were searched up to July 2012. REVIEW METHODS: A systematic review of the evidence was carried out using standard methods. Single-gate studies were used to estimate the accuracy of OSNA with histopathology as the reference standard. The cost-effectiveness analysis adapted an existing simulation model of the long-term costs and health implications of early breast cancer diagnostic outcomes. The model accounted for the costs of an extended first operation with intraoperative testing, the loss of health-related quality of life (disutility) from waiting for postoperative test results, disutility and costs of a second operation, and long-term costs and disutility from lymphoedema related to ALND, adjuvant therapy, locoregional recurrence and metastatic recurrence. RESULTS: A total of 724 references were identified in the searches, of which 17 studies assessing test accuracy were included in the review, 15 on OSNA and two on Metasin. Both Metasin studies were unpublished. OSNA sensitivity of 84.5% [95% confidence interval (CI) 74.7% to 91.0%] and specificity of 91.8% (95% CI 87.8% to 94.6%) for patient nodal status were estimated in a meta-analysis of five studies [unadjusted for tissue allocation bias (TAB)]. At these values and a 20% node-positive rate, OSNA resulted in lifetime discounted cost-savings of £498 and a quality-adjusted life-year (QALY) loss of 0.048 relative to histopathology, that is, £4324 saved per QALY lost. The most favourable plausible scenario for OSNA in terms of the node-positive rate (range 10-40%), diagnostic accuracy values (91.3% sensitivity and 94.2% specificity, from three reports that adjusted for TAB), the costs of histopathology, OSNA and second surgery, and long-term costs and utilities resulted in a maximum saving per QALY lost of £10,500; OSNA sensitivity and specificity would need to be ≥ 95% for this figure to be ≥ £20,000. LIMITATIONS: There is limited evidence on the diagnostic test accuracy of intraoperative tests. The quality of information on costs of resource utilisation during the diagnostic pathway is low and no evidence exists on the disutility of waiting for a second surgery. No comparative studies exist that report clinical outcomes of intraoperative diagnostic tests. These knowledge gaps have more influence on the decision than current uncertainty in the performance of postoperative histopathology in standard practice. CONCLUSIONS: One-step nucleic acid amplification is not cost-effective for the intraoperative diagnosis of sentinel lymph node metastases. OSNA is less accurate than histopathology and the consequent loss of health benefits in this patient group is not compensated for by health gains elsewhere in the health system that may be obtained with the cost-savings made. The evidence on Metasin is insufficient to evaluate its cost-effectiveness. STUDY REGISTRATION: This study is registered as PROSPERO CRD42012002889. FUNDING: The National Institute for Health Research Health Technology Assessment programme