Early Thermal Evolution of Planetesimals and its Impact on Processing and Dating of Meteoritic Material

Radioisotopic ages for meteorites and their components provide constraints on the evolution of small bodies: timescales of accretion, thermal and aqueous metamorphism, differentiation, cooling and impact metamorphism. Realising that the decay heat of short-lived nuclides (e.g. 26Al, 60Fe), was the main heat source driving differentiation and metamorphism, thermal modeling of small bodies is of utmost importance to set individual meteorite age data into the general context of the thermal evolution of their parent bodies, and to derive general conclusions about the nature of planetary building blocks in the early solar system. As a general result, modelling easily explains that iron meteorites are older than chondrites, as early formed planetesimals experienced a higher concentration of short-lived nuclides and more severe heating. However, core formation processes may also extend to 10 Ma after formation of Calcium-Aluminum-rich inclusions (CAIs). A general effect of the porous nature of the starting material is that relatively small bodies (< few km) will also differentiate if they form within 2 Ma after CAIs. A particular interesting feature to be explored is the possibility that some chondrites may derive from the outer undifferentiated layers of asteroids that are differentiated in their interiors. This could explain the presence of remnant magnetization in some chondrites due to a planetary magnetic field.Comment: 24 pages, 9 figures, Accepted for publication as a chapter in Protostars and Planets VI, University of Arizona Press (2014), eds. H. Beuther, R. Klessen, C. Dullemond, Th. Hennin

\u3cem\u3eDrosophila\u3c/em\u3e Vitelline Membrane Assembly: A Critical Role for an Evolutionarily Conserved Cysteine in the “VM domain” of sV23

The vitelline membrane (VM), the oocyte proximal layer of the Drosophila eggshell, contains four major proteins (VMPs) that possess a highly conserved “VM domain” which includes three precisely spaced, evolutionarily conserved, cysteines (CX7CX8C). Focusing on sV23, this study showed that the three cysteines are not functionally equivalent. While substitution mutations at the first (C123S) or third (C140S) cysteines were tolerated, females with a substitution at the second position (C131S) were sterile. Fractionation studies showed that sV23 incorporates into a large disulfide linked network well after its secretion ceases, suggesting that post-depositional mechanisms are in place to restrict disulfide bond formation until late oogenesis, when the oocyte no longer experiences large volume increases. Affinity chromatography utilizing histidine tagged sV23 alleles revealed small sV23 disulfide linked complexes during the early stages of eggshell formation that included other VMPs, namely sV17 and Vml. The early presence but late loss of these associations in an sV23 double cysteine mutant suggests that reorganization of disulfide bonds may underlie the regulated growth of disulfide linked networks in the vitelline membrane. Found within the context of a putative thioredoxin active site (CXXS) C131, the critical cysteine in sV23, may play an important enzymatic role in isomerizing intermolecular disulfide bonds during eggshell assembly

Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort

This study examines the relationship between long-term intake of six flavonoid classes and incidence of CVD and CHD, using a comprehensive flavonoid database and repeated measures of intake, while accounting for possible confounding by components of a healthy dietary pattern. Flavonoid intakes were assessed using a FFQ among the Framingham Offspring Cohort at baseline and three times during follow-up. Cox proportional hazards regression was used to characterise prospective associations between the natural logarithms of flavonoid intakes and CVD incidence using a time-dependent approach, in which intake data were updated at each examination to represent average intakes from previous examinations. Mean baseline age was 54 years, and 45 % of the population was male. Over an average 14·9 years of follow-up among 2880 participants, there were 518 CVD events and 261 CHD events. After multivariable adjustment, only flavonol intake was significantly associated with lower risk of CVD incidence (hazard ratios (HR) per 2·5-fold flavonol increase = 0·86, Ptrend = 0·05). Additional adjustment for total fruit and vegetable intake and overall diet quality attenuated this observation (HR = 0·89, Ptrend = 0·20 and HR = 0·92, Ptrend = 0·33, respectively). There were no significant associations between flavonoids and CHD incidence after multivariable adjustment. Our findings suggest that the observed association between flavonol intake and CVD risk may be a consequence of better overall diet. However, the strength of this non-significant association was also consistent with relative risks observed in previous meta-analyses, and therefore a modest benefit of flavonol intake on CVD risk cannot be ruled out

Data management and language enhancement for generalized set theory computer language for operation of large relational databases

This report covers the study of the relational database implementation in the NASCAD computer program system. The existing system is used primarily for computer aided design. Attention is also directed to a hidden-surface algorithm for final drawing output

Separated Fringe Packet Observations with the CHARA Array III. The Very High Eccentricity Binary HR 7345

After an eleven year observing campaign, we present the combined visual{spectroscopic orbit of the formerly unremarkable bright star HR 7345 (HD 181655, HIP 94981, GJ 754.2). Using the Separated Fringe Packet (SFP) method with the CHARA Array, we were able to determine a difficult to complete orbital period of 331.609 +/- 0.004 days. The 11 month period causes the system to be hidden from interferometric view behind the Sun for 3 years at a time. Due to the high eccentricity orbit of about 90% of a year, after 2018 January the periastron phase will not be observable again until late 2021. Hindered by its extremely high eccentricity of 0.9322 +/- 0.0001, the double-lined spectroscopic phase of HR 7345 is observable for 15 days. Such a high eccentricity for HR 7345 places it among the most eccentric systems in catalogs of both visual and spectroscopic orbits. For this system we determine nearly identical component masses of 0.941 +/- 0.076 Msun and 0.926 +/- 0.075 Msun as well as an orbital parallax of 41.08 +/- 0.77 mas.Comment: 20 pages, 3 figures, 4 table

From Small to Large Hits: Spreading the Online Message to Academic and Administrative Staff via Strategically-Targeted Development Activities

This paper reports on how a university is implementing a capacity-building academic staff development program using a three-pronged approach that draws on adult learning, social learning and capacity-building literature. This approach was designed to enable staff to provide engaging and pedagogically sound online experiences for the students at the University of Newcastle, NSW Australia. Data have been gathered throughout the implementation of this program to evaluate its impact and to inform future refinements of the program. The paper concludes with reflections from staff facilitating the program about the challenges, successes and future of the program

The Cord Approach to Extensible Concurrency Control

Database management systems (DBMSs) have been increasingly used for advanced application domains, such as software development environments, workflow management systems, computer-aided design and manufacturing, and managed healthcare. In these domains, the standard correctness model of serializability is often too restrictive. The authors introduce the notion of a concurrency control language (CCL) that allows a database application designer to specify concurrency control policies to tailor the behavior of a transaction manager. A well-crafted set of policies defines an extended transaction model. The necessary semantic information required by the CCL run-time engine is extracted from a task manager, a (logical) module by definition included in all advanced applications. This module stores task models that encode the semantic information about the transactions submitted to the DBMS. They have designed a rule-based CCL, called CORD, and have implemented a run-time engine that can be hooked to a conventional transaction manager to implement the sophisticated concurrency control required by advanced database applications. They present an architecture for systems based on CORD and describe how they integrated the CORD engine with the Exodus Storage Manager to implement altruistic locking

Incremental Process Support for Code Reengineering

Reengineering a large code base can be a monumental task, and the situation becomes even worse if the code is concomitantly being modified. For the past two years, we have been using the Marvel process centered environment (PCE) for all of our software development and are currently using it to develop the Oz PCE (Marvel's successor). Towards this effort, we are reengineering Oz's code base to isolate the process engine, transaction manager, and object management system as separate components that can be mixed and matched in arbitrary systems. In this paper, we show how a PCE can guide and assist teams of users in carrying out code reengineering while allowing them to continue their normal code development. The key features to this approach are its incremental nature and the ability of the PCE to automate most of the tasks necessary to maintain the consistency of the code base