The Role of Functional, Social, and Mobility Dynamics in Facilitating Older African Americans Participation in Clinical Research

Purpose: Older African Americans experience disproportionately higher incidence of morbidity and mortality related to chronic and infectious diseases, yet are significantly underrepresented in clinical research compared to other racial and ethnic groups. This study aimed to understand the extent to which social support, transportation access, and physical impediments function as barriers or facilitators to clinical trial recruitment of older African Americans. Methods: Participants (N=221) were recruited from six African American churches in Atlanta and surveyed on various influences on clinical trial participation

Enrollment in YFV Vaccine Trial: An Evaluation of Recruitment Outcomes Associated with a Randomized Controlled Double-Blind Trial of a Live Attenuated Yellow Fever Vaccine

This investigation evaluated several factors associated with diverse participant enrollment of a clinical trial assessing safety, immunogenicity, and comparative viremia associated with administration of 17-D live, attenuated yellow fever vaccine given alone or in combination with human immune globulin. We obtained baseline participant information (e.g., sociodemographic, medical) and followed recruitment outcomes from 2005 to 2007. Of 355 potential Yellow Fever vaccine study participants, 231 cases were analyzed. Strong interest in study participation was observed among racial and ethnically diverse persons with 36.34% eligible following initial study screening, resulting in 18.75% enrollment. The percentage of white participants increased from 63.66% (prescreened sample) to 81.25% (enrollment group). The regression model was significant with white race as a predictor of enrollment (OR=2.744, 95% CI=1.415-5.320, p=0.003).In addition, persons were more likely to enroll via direct outreach and referral mechanisms compared to mass advertising (OR=2.433, 95% CI=1.102-5.369). The findings indicate that racially diverse populations can be recruited to vaccine clinical trials, yet actual enrollment may not reflect that diversit

Geobase Information System Impacts on Space Image Formats

As Geobase Information Systems increase in number, size and complexity, the format compatability of satellite remote sensing data becomes increasingly more important. Because of the vast and continually increasing quantity of data available from remote sensing systems the utility of these data is increasingly dependent on the degree to which their formats facilitate, or hinder, their incorporation into Geobase Information Systems. To merge satellite data into a geobase system requires that they both have a compatible geographic referencing system. Greater acceptance of satellite data by the user community will be facilitated if the data are in a form which most readily corresponds to existing geobase data structures. The conference addressed a number of specific topics and made recommendations

Testing the binary hypothesis for the formation and shaping of planetary nebulae

There is no quantitative theory to explain why a high 80% of all planetary nebulae are non-spherical. The Binary Hypothesis states that a companion to the progenitor of a central star of planetary nebula is required to shape the nebula and even for a planetary nebula to be formed at all. A way to test this hypothesis is to estimate the binary fraction of central stars of planetary nebulae and to compare it with that of the main sequence population. Preliminary results from photometric variability and the infrared excess techniques indicate that the binary fraction of central stars of planetary nebulae is higher than that of the main sequence, implying that PNe could preferentially form via a binary channel. This article briefly reviews these results and current studies aiming to refine the binary fraction.Comment: EUROWD12 Proceeding

Planetary nebulae : getting closer to an unbiased binary fraction

Why 80% of planetary nebulae are not spherical is not yet understood. The Binary Hypothesis states that a companion to the progenitor of the central star of a planetary nebula is required to shape the nebula and even for a planetary nebula to be formed at all. A way to test this hypothesis is to estimate the binary fraction of central stars of planetary nebula and to compare it with the main sequence population. Preliminary results from photometric variability and infrared excess techniques indicate that the binary fraction of central stars of planetary nebulae is higher than that of the putative main sequence progenitor population, implying that PNe could be preferentially formed via a binary channel. This article briefly reviews these results and future studies aiming to refine the binary fraction.Comment: SF2A 2012 proceeding

The planetary nebula Abell 48 and its [WN] nucleus

We have conducted a detailed multi-wavelength study of the peculiar nebula Abell 48 and its central star. We classify the nucleus as a helium-rich, hydrogen-deficient star of type [WN4-5]. The evidence for either a massive WN or a low-mass [WN] interpretation is critically examined, and we firmly conclude that Abell 48 is a planetary nebula (PN) around an evolved low-mass star, rather than a Population I ejecta nebula. Importantly, the surrounding nebula has a morphology typical of PNe, and is not enriched in nitrogen, and thus not the `peeled atmosphere' of a massive star. We estimate a distance of 1.6 kpc and a reddening, E(B-V) = 1.90 mag, the latter value clearly showing the nebula lies on the near side of the Galactic bar, and cannot be a massive WN star. The ionized mass (~0.3 M_Sun) and electron density (700 cm^-3) are typical of middle-aged PNe. The observed stellar spectrum was compared to a grid of models from the Potsdam Wolf-Rayet (PoWR) grid. The best fit temperature is 71 kK, and the atmospheric composition is dominated by helium with an upper limit on the hydrogen abundance of 10 per cent. Our results are in very good agreement with the recent study of Todt et al., who determined a hydrogen fraction of 10 per cent and an unusually large nitrogen fraction of ~5 per cent. This fraction is higher than any other low-mass H-deficient star, and is not readily explained by current post-AGB models. We give a discussion of the implications of this discovery for the late-stage evolution of intermediate-mass stars. There is now tentative evidence for two distinct helium-dominated post-AGB lineages, separate to the helium and carbon dominated surface compositions produced by a late thermal pulse. Further theoretical work is needed to explain these recent discoveries.Comment: 19 pages, 10 figures, to appear in MNRAS. Version 3 incorporates proof correction

Atypicalities and Apartment Rent Concessions

This paper examines the use and value of rental concession using a 1988 sample of apartment rents in the Greensboro/High Point/Winston-Salem (North Carolina) MSA. The first section develops an approach to the problem and the second section estimates a logit model to predict the use of concessions as a pricing strategy based on characteristics of the apartment. The third section employs a hedonic pricing model to measure the average value of rental concessions in the Greensboro market. The final section summarizes relevant findings.

Elevated glutamatergic compounds in pregenual anterior cingulate in pediatric autism spectrum disorder demonstrated by 1H MRS and 1H MRSI.

Recent research in autism spectrum disorder (ASD) has aroused interest in anterior cingulate cortex and in the neurometabolite glutamate. We report two studies of pregenual anterior cingulate cortex (pACC) in pediatric ASD. First, we acquired in vivo single-voxel proton magnetic resonance spectroscopy ((1)H MRS) in 8 children with ASD and 10 typically developing controls who were well matched for age, but with fewer males and higher IQ. In the ASD group in midline pACC, we found mean 17.7% elevation of glutamate + glutamine (Glx) (p<0.05) and 21.2% (p<0.001) decrement in creatine + phosphocreatine (Cr). We then performed a larger (26 subjects with ASD, 16 controls) follow-up study in samples now matched for age, gender, and IQ using proton magnetic resonance spectroscopic imaging ((1)H MRSI). Higher spatial resolution enabled bilateral pACC acquisition. Significant effects were restricted to right pACC where Glx (9.5%, p<0.05), Cr (6.7%, p<0.05), and N-acetyl-aspartate + N-acetyl-aspartyl-glutamate (10.2%, p<0.01) in the ASD sample were elevated above control. These two independent studies suggest hyperglutamatergia and other neurometabolic abnormalities in pACC in ASD, with possible right-lateralization. The hyperglutamatergic state may reflect an imbalance of excitation over inhibition in the brain as proposed in recent neurodevelopmental models of ASD

From meadows to milk to mucosa – adaptation of Streptococcus and Lactococcus species to their nutritional environments

Lactic acid bacteria (LAB) are indigenous to food-related habitats as well as associated with the mucosal surfaces of animals. The LAB family Streptococcaceae consists of the genera Lactococcus and Streptococcus. Members of the family include the industrially important species Lactococcus lactis, which has a long history safe use in the fermentative food industry, and the disease-causing streptococci Streptococcus pneumoniae and Streptococcus pyogenes. The central metabolic pathways of the Streptococcaceae family have been extensively studied because of their relevance in the industrial use of some species, as well as their influence on virulence of others. Recent developments in high-throughput proteomic and DNA-microarray techniques, in in vivo NMR studies, and importantly in whole-genome sequencing have resulted in new insights into the metabolism of the Streptococcaceae family. The development of cost-effective high-throughput sequencing has resulted in the publication of numerous whole-genome sequences of lactococcal and streptococcal species. Comparative genomic analysis of these closely related but environmentally diverse species provides insight into the evolution of this family of LAB and shows that the relatively small genomes of members of the Streptococcaceae family have been largely shaped by the nutritionally rich environments they inhabit.