13,691 research outputs found
Magnetic transitions in Pr2NiO4 single crystal
The magnetic properties of a stoichiometric Pr2NiO4 single crystal have been examined by means of the temperature dependence of the complex ac susceptibility and the isothermal magnetization in fields up to 200 kOe at T=4.2 K. Three separate phases have been identified and their anisotropic character has been analyzed. A collinear antiferromagnetic phase appears first between TN = 325 K and Tc1 = 115 K, where the Pr ions are polarized by an internal magnetic field. At Tc1 a first modification of the magnetic structure occurs in parallel with a structural phase transition (Bmab to P42/ncm). This magnetic transition has a firstâorder character and involves both the outâofâplane and the inâplane spin components (magnetic modes gx and gxcyfz, respectively). A second magnetic transition having also a firstâorder character is also clearly identified at Tc2 = 90 K which corresponds to a spin reorientation process (gxcyfz to cxgyaz magnetic modes). It should be noted as well that the outâofâphase component of Ïac shows a peak around 30 K which reflects the coexistence of both magnetic configurations in a wide temperature interval. Finally, two fieldâinduced transitions have been observed at 4.2 K when the field is directed along the c axis. We propose that the highâfield anomaly arises from a metamagnetic transition of the weak ferromagnetic component, similarly to La2CuO4
Kinematics of the Outflow From The Young Star DG Tau B: Rotation in the vicinities of an optical jet
We present CO(2-1) line and 1300 m continuum observations made
with the Submillimeter Array (SMA) of the young star DG Tau B. We find, in the
continuum observations, emission arising from the circumstellar disk
surrounding DG Tau B. The CO(2-1) line observations, on the other hand,
revealed emission associated with the disk and the asymmetric outflow related
with this source. Velocity asymmetries about the flow axis are found over the
entire length of the flow. The amplitude of the velocity differences is of the
order of 1 -- 2 km s over distances of about 300 -- 400 AU. We interpret
them as a result of outflow rotation. The sense of the outflow and disk
rotation is the same. Infalling gas from a rotating molecular core cannot
explain the observed velocity gradient within the flow. Magneto-centrifugal
disk winds or photoevaporated disk winds can produce the observed rotational
speeds if they are ejected from a keplerian disk at radii of several tens of
AU. Nevertheless, these slow winds ejected from large radii are not very
massive, and cannot account for the observed linear momentum and angular
momentum rates of the molecular flow. Thus, the observed flow is probably
entrained material from the parent cloud. DG Tau B is a good laboratory to
model in detail the entrainment process and see if it can account for the
observed angular momentum.Comment: Accepted to Ap
Measurements of thermodynamic and transport properties of EuC: a low-temperature analogue of EuO
EuC is a ferromagnet with a Curie-temperature of K. It
is semiconducting with the particularity that the resistivity drops by about 5
orders of magnitude on cooling through , which is therefore called a
metal-insulator transition. In this paper we study the magnetization, specific
heat, thermal expansion, and the resistivity around this ferromagnetic
transition on high-quality EuC samples. At we observe well defined
anomalies in the specific heat and thermal expansion data.
The magnetic contributions of and can satisfactorily be
described within a mean-field theory, taking into account the magnetization
data. In zero magnetic field the magnetic contributions of the specific heat
and thermal expansion fulfill a Gr\"uneisen-scaling, which is not preserved in
finite fields. From an estimation of the pressure dependence of via
Ehrenfest's relation, we expect a considerable increase of under applied
pressure due to a strong spin-lattice coupling. Furthermore the influence of
weak off stoichiometries in EuC was studied. It is
found that strongly affects the resistivity, but hardly changes the
transition temperature. In all these aspects, the behavior of EuC strongly
resembles that of EuO.Comment: 7 pages, 6 figure
Effect of plasma elongation on current dynamics during tokamak disruptions
Plasma terminating disruptions in tokamaks may result in relativistic runaway
electron beams with potentially serious consequences for future devices with
large plasma currents. In this paper we investigate the effect of plasma
elongation on the coupled dynamics of runaway generation and resistive
diffusion of the electric field. We find that elongated plasmas are less likely
to produce large runaway currents, partly due to the lower induced electric
fields associated with larger plasmas, and partly due to direct shaping
effects, which mainly lead to a reduction in the runaway avalanche gain.Comment: 11 pages, 3 figure
The multikinase inhibitor ECâ70124 synergistically increased the antitumor activity of doxorubicin in sarcomas
Cytotoxic drugs like doxorubicin remain as the most utilized agents in sarcoma treatment. However, advanced sarcomas are often resistant, thus stressing the need for new therapies aimed to overcome this resistance. Multikinase inhibitors provide an efficient way to target several pro-tumorigenic pathways using a single agent and may constitute a valuable strategy in the treatment of sarcomas, which frequently show an aberrant activation of pro-tumoral kinases. Therefore, we studied the antitumor activity of EC-70124, an indolocarbazole analog that have demonstrated a robust ability to inhibit a wide range of pro-survival kinases. Evaluation of the phospho-kinase profile in cell-of-origin sarcoma models and/or sarcoma primary cell lines evidenced that PI3K/AKT/mTOR, JAK/STAT or SRC were among the most highly activated pathways. In striking contrast with the structurally related drug midostaurin, EC-70124 efficiently prevented the phosphorylation of these targets and robustly inhibited proliferation through a mechanism associated to the induction of DNA damage, cell cycle arrest and apoptosis. In addition, EC-70124 was able to partially reduce tumor growth in vivo. Importantly, this compound inhibited the expression and activity of ABC efflux pumps involved in drug resistance. In line with this ability, we found that the combined treatment of EC-70124 with doxorubicin resulted in a synergistic cytotoxic effect in vitro and an increased antitumor activity of this cytotoxic drug in vivo. Altogether, these results uncover the capability of the novel multikinase inhibitor EC-70124 to counteract drug resistance in sarcoma and highlight its therapeutic potential when combined with current treatmentsPeer ReviewedPostprint (author's final draft
Permanent genetic memory with >1-byte capacity
Genetic memory enables the recording of information in the DNA of living cells. Memory can record a transient environmental signal or cell state that is then recalled at a later time. Permanent memory is implemented using irreversible recombinases that invert the orientation of a unit of DNA, corresponding to the [0,1] state of a bit. To expand the memory capacity, we have applied bioinformatics to identify 34 phage integrases (and their cognate attB and attP recognition sites), from which we build 11 memory switches that are perfectly orthogonal to each other and the FimE and HbiF bacterial invertases. Using these switches, a memory array is constructed in Escherichia coli that can record 1.375 bytes of information. It is demonstrated that the recombinases can be layered and used to permanently record the transient state of a transcriptional logic gate.United States. Defense Advanced Research Projects Agency (DARPA CLIO N66001-12-C-4016)United States. Defense Advanced Research Projects Agency (DARPA CLIO N66001-12-C-4018)United States. Office of Naval Research. Multidisciplinary University Research Initiative (N00014-13-1-0074)National Institutes of Health (U.S.) (GM095765)National Institute of General Medical Sciences (U.S.) (P50 GM098792)National Science Foundation (U.S.). Synthetic Biology Engineering Research Center (SynBERC EEC0540879)FA9550-11-C-0028American Society for Engineering Education. National Defense Science and Engineering Graduate Fellowship (32 CFR 168a
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