750 Natalia the economic and legal analysis of the terms of international delivery contracts involving Russian suppliers

Purpose: The article presents an economic and legal analysis of the terms of contracts for international delivery of goods involving Russian suppliers. Design/Methodology/Approach: The authors analysed the international norms of regulating relations for the goods’ delivery involving the foreign element. Terms of the goods delivery are investigated according to the national legislation of the Russian Federation. Findings: As a result, it is necessary to use an economic and legal approach when developing contract terms for the goods’ delivery to take into account norms of international law, the national legislation of the supplier country and in accordance with the calculations of the contract price and payment terms. Practical Implications: The proposed method is in accordance with the international legal framework and it can be adopted by the Russian Federation easily. Originality/Value: There is no such an approach eligible to modernize the existing system in the country.peer-reviewe

E-learning as a modern resource of education

E-learning is becoming increasingly popular today. It is being widely implemented not only in educational institutions but in business and industrial enterprises demanding the fastest and the cheapest means of information exchange and communication. This article is dedicated to eliciting of the background factors of successful implementation and favourable environment to develop e-learning programs. It analyses the e-learning teaching process and methods practiced in several countries, including Russia, and empathizes the major issues and problems the national systems of education have had to face recentl

FRUIT AND BERRY CROPS IN THE ENVIRONMENTS OF THE BUZULUKSKY BOR NATIONAL PARK

Buzuluksky Bor is the name of the largest woodland in the steppe zone (86,600 ha) of Northern Eurasia, and the only one in the Transvolga steppe. Woody vegetation of this forest consists of conifers (70%) and broadleaf trees (30%). Many of the latter produce edible fruits and berries. In addition to indigenous species, a significant part is formed by the introduced ones which have adapted to the specific conditions of this woodland. In 2007, a large area of the pine forest became part of the Buzuluksky Bor National Park

Kaposi's sarcoma associated with Wegener’s granulomatosi

A case of Kaposi's sarcoma development in a pt with Wegener's granulomatosis during immunosupres- sive treatment with cyclophosphane and prednisolone

Isolation of two strains of West Nile virus during an outbreak in southern Russia, 1999.

From July to September 1999, a widespread outbreak of meningoencephalitis associated with West Nile virus (Flavivirus, Flaviviridae) occurred in southern Russia, with hundreds of cases and dozens of deaths. Two strains of West Nile virus isolated from patient serum and brain-tissue samples reacted in hemagglutination-inhibition and neutralization tests with patients' convalescent-phase sera and immune ascites fluid from other strains of West Nile virus

Circulating Cell-Free DNA in Dogs with Mammary Tumors: Short and Long Fragments and Integrity Index

Circulating cell-free DNA (cfDNA) has been considered an interesting diagnostic/prognostic plasma biomarker in tumor-bearing subjects. In cancer patients, cfDNA can hypothetically derive from tumor necrosis/apoptosis, lysed circulating cells, and some yet unrevealed mechanisms of active release. This study aimed to preliminarily analyze cfDNA in dogs with canine mammary tumors (CMTs). Forty-four neoplastic, 17 non-neoplastic disease-bearing, and 15 healthy dogs were recruited. Necrosis and apoptosis were also assessed as potential source of cfDNA on 78 CMTs diagnosed from the 44 dogs. The cfDNA fragments and integrity index significantly differentiated neoplastic versus non-neoplastic dogs (P<0.05), and allowed the distinction between benign and malignant lesions (P<0.05). Even if without statistical significance, the amount of cfDNA was also affected by tumor necrosis and correlated with tumor size and apoptotic markers expression. A significant (P<0.01) increase of Bcl-2 in malignant tumors was observed, and in metastatic CMTs the evasion of apoptosis was also suggested. This study, therefore, provides evidence that cfDNA could be a diagnostic marker in dogs carrying mammary nodules suggesting that its potential application in early diagnostic procedures should be further investigated

Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation

Tumour development is characterised by the increased circulating DNA (cirDNA) concentration and by tumour-related changes in blood plasma DNA. Concentration of cirDNA and methylation of RARβ2, RASSF1A and HIC-1 gene promoters were investigated in cell-free and cell-surface-bound fractions from healthy donors, patients with breast cancer, and patients with breast fibroadenoma. Tumour development was shown to lead to significant changes in the distribution of cirDNA between cell-free and cell-surface-bound fractions. Analysis of RARβ2 and RASSF1A methylation in the total cirDNA provides 95% diagnostic coverage in breast cancer patients, 60% in patients with benign lesions, and is without false-positive results in healthy women. Results of the study indicate that methylation-specific PCR of RARβ2 and RASSF1A genes based on the total cirDNA combined with the quantitative analysis of cirDNA distribution between cell-bound and cell-free fractions in blood provide the sensitive and accurate detection and discrimination of malignant and benign breast tumours

The little skate genome and the evolutionary emergence of wing-like fins

Skates are cartilaginous fish whose body plan features enlarged wing-like pectoral fins, enabling them to thrive in benthic environments1,2. However, the molecular underpinnings of this unique trait remain unclear. Here we investigate the origin of this phenotypic innovation by developing the little skate Leucoraja erinacea as a genomically enabled model. Analysis of a high-quality chromosome-scale genome sequence for the little skate shows that it preserves many ancestral jawed vertebrate features compared with other sequenced genomes, including numerous ancient microchromosomes. Combining genome comparisons with extensive regulatory datasets in developing fins—including gene expression, chromatin occupancy and three-dimensional conformation—we find skate-specific genomic rearrangements that alter the three-dimensional regulatory landscape of genes that are involved in the planar cell polarity pathway. Functional inhibition of planar cell polarity signalling resulted in a reduction in anterior fin size, confirming that this pathway is a major contributor to batoid fin morphology. We also identified a fin-specific enhancer that interacts with several hoxa genes, consistent with the redeployment of hox gene expression in anterior pectoral fins, and confirmed its potential to activate transcription in the anterior fin using zebrafish reporter assays. Our findings underscore the central role of genome reorganization and regulatory variation in the evolution of phenotypes, shedding light on the molecular origin of an enigmatic trait

Оценка физического развития и питания детей в возрасте 1–3 лет, проживающих в г. Москве

Irrational feeding can lead to a child’s physical and intellectual development disorders, a decrease in the body’s ability to resist aggressive environmental factors.Aim: to evaluate the physical development and nutrition of children aged 1–3 years living in Moscow.Methods: 106 children aged 1–3 years were examined: group 1 (n = 59) was comprised of children aged 1–2 years, group 2 — children aged 2–3 years (n = 47). Anthropometric data was evaluated using AntroPlus (WHO software). The following Z-score figures were calculated: WAZ (body mass for age), HAZ (height for age) and BAZ (body mass index for age). Nutrition was evaluated by reproducing a 3-day food allowance (actual nutrition) using the Dietplan 6 software. Figures analyzed: the volume of consumed food, daily caloricity, the amount of consumed proteins, fats and carbohydrates.Results: for the majority (76.4%) of examined children BAZ was between -2 and +1. 20% of children had an excessive body mass and obesity (BAZ &gt; 1). Children with an excessive body mass demonstrated exceeding volumes of food consumption (by about 200–300g. per day, p &lt; 0.001), protein consumption by 47.5%, fat consumption — 36.7% and caloricity by 21.3% (p &lt; 0.001) as compared with the recommended consumption norms.Conclusion: the revealed nutrition disorders in children aged 1–3 years (overeating and unbalanced diet) lead to an increased body mass and obesity. Children with high body mass indexes at birth and Z-score and BAZ at the time of the study can be attributed to the obesity risk group. The BAZ index is the most informative one in terms of evaluating the child’s nutritive status.Нерациональное питание может привести к нарушениям физического и интеллектуального развития ребенка, снижению сопротивляемости организма к агрессивным факторам внешней среды.Цель исследования: оценить физическое развитие и питание детей в возрасте 1–3 лет, проживающих в г. Москве.Методы: обследовано 106 детей в возрасте от 1 до 3 лет: I группу (n = 59) составили дети 1–2 лет, II группу — дети 2–3 лет (n = 47). Антропометрические данные оценивались с использованием программы WHO AnthroPlus: расчитывались показатели Z-score — массы тела для возраста (WAZ), длины тела для возраста (HAZ), а также индекс массы тела/возраст (BAZ). Оценка питания проводилась методом воспроизведения 3-дневного рациона (фактического питания) с использованием программы Dietplan 6. Анализировались объем съеденной пищи, суточная калорийность питания, количество потребляемых белков, жиров, углеводов.Результаты: для большинства (76,4%) обследованных детей были характерны средневозрастные показатели физического развития и нутритивного статуса (BAZ от -2 до +1). У 1/5 детей были выявлены избыточная масса тела и ожирение (BAZ &gt; 1). При избыточной массе тела, особенно у детей 1–2 лет, было установлено превышение потребляемых объемов пищи на 200–300 г/сут, белка — на 47,5%, жира — на 36,7% и энергетической ценности — на 21,3% (p &lt; 0,001) по сравнению с рекомендуемыми нормами потребления.Заключение: выявленные нарушения питания у детей в возрасте 1–3 лет (переедание и разбалансированный рацион) приводят к развитию у них избыточной массы тела вплоть до ожирения. Детей с высокими показателями веса при рождении и Z-score BAZ на момент исследования можно отнести к группе риска по развитию ожирения. Наиболее информативным для оценки нутритивного статуса ребенка является показатель BAZ