153 research outputs found
Charged Higgs boson contribution to for very large in the two Higgs doublet model with UHE-neutrinos
We study the deep inelastic process
(with an isoscalar nucleon), in the context of the
two Higgs doublet model {\it type two} (2HDM(II)). In particular, we discuss
the contribution to the total cross section of diagrams, in which a charged
Higgs boson is exchanged. We show that for large values of such
contribution for an inclusive dispersion generated through the collision of an
ultrahigh energy tau-neutrino on a target nucleon can reach up to 57% of the
value of the contribution of the exchange diagrams (i.e. can reach up to
57% of the standard model (SM) prediction) and could permit to distinguish
between the SM and the 2HDM(II) predictions at the Pierre Auger Observatory.Comment: 10 pages, 5 figure
Study of cosmic ray interaction model based on atmospheric muons for the neutrino flux calculation
We have studied the hadronic interaction for the calculation of the
atmospheric neutrino flux by summarizing the accurately measured atmospheric
muon flux data and comparing with simulations. We find the atmospheric muon and
neutrino fluxes respond to errors in the -production of the hadronic
interaction similarly, and compare the atmospheric muon flux calculated using
the HKKM04 code with experimental measurements. The data show
good agreement in the 130 GeV/c range, but a large disagreement above 30
GeV/c. The the ratio shows sizable differences at lower and
higher momenta for opposite directions. As the disagreements are considered to
be due to assumptions in the hadronic interaction model, we try to improve it
phenomenologically based on the quark parton model. The improved interaction
model reproduces the observed muon flux data well. The calculation of the
atmospheric neutrino flux will be reported in the following pape
Radiation in Lorentz violating electrodynamics
Synchrotron radiation is analyzed in the classical effective Lorentz
invariance violating model of Myers-Pospelov. Within the full far-field
approximation we compute the electric and magnetic fields, the angular
distribution of the power spectrum and the total emitted power in the m-th
harmonic, as well as the polarization. We find the appearance of rather
unexpected and large amplifying factors, which go together with the otherwise
negligible naive expansion parameter. This opens up the possibility of further
exploring Lorentz invariance violations by synchrotron radiation measurements
in astrophysical sources where these amplifying factors are important.Comment: Presented at the Second Mexican Meeting on Theoretical and
Experimental Physics, El Colegio Nacional, Mexico City, 6-10 September 200
Lateral Gene Expression in Drosophila Early Embryos Is Supported by Grainyhead-Mediated Activation and Tiers of Dorsally-Localized Repression
The general consensus in the field is that limiting amounts of the transcription factor Dorsal establish dorsal boundaries of genes expressed along the dorsal-ventral (DV) axis of early Drosophila embryos, while repressors establish ventral boundaries. Yet recent studies have provided evidence that repressors act to specify the dorsal boundary of intermediate neuroblasts defective (ind), a gene expressed in a stripe along the DV axis in lateral regions of the embryo. Here we show that a short 12 base pair sequence (“the A-box”) present twice within the ind CRM is both necessary and sufficient to support transcriptional repression in dorsal regions of embryos. To identify binding factors, we conducted affinity chromatography using the A-box element and found a number of DNA-binding proteins and chromatin-associated factors using mass spectroscopy. Only Grainyhead (Grh), a CP2 transcription factor with a unique DNA-binding domain, was found to bind the A-box sequence. Our results suggest that Grh acts as an activator to support expression of ind, which was surprising as we identified this factor using an element that mediates dorsally-localized repression. Grh and Dorsal both contribute to ind transcriptional activation. However, another recent study found that the repressor Capicua (Cic) also binds to the A-box sequence. While Cic was not identified through our A-box affinity chromatography, utilization of the same site, the A-box, by both factors Grh (activator) and Cic (repressor) may also support a “switch-like” response that helps to sharpen the ind dorsal boundary. Furthermore, our results also demonstrate that TGF-β signaling acts to refine ind CRM expression in an A-box independent manner in dorsal-most regions, suggesting that tiers of repression act in dorsal regions of the embryo
Sensitivity of the IceCube Detector to Astrophysical Sources of High Energy Muon Neutrinos
We present the results of a Monte-Carlo study of the sensitivity of the
planned IceCube detector to predicted fluxes of muon neutrinos at TeV to PeV
energies. A complete simulation of the detector and data analysis is used to
study the detector's capability to search for muon neutrinos from sources such
as active galaxies and gamma-ray bursts. We study the effective area and the
angular resolution of the detector as a function of muon energy and angle of
incidence. We present detailed calculations of the sensitivity of the detector
to both diffuse and pointlike neutrino emissions, including an assessment of
the sensitivity to neutrinos detected in coincidence with gamma-ray burst
observations. After three years of datataking, IceCube will have been able to
detect a point source flux of E^2*dN/dE = 7*10^-9 cm^-2s^-1GeV at a 5-sigma
significance, or, in the absence of a signal, place a 90% c.l. limit at a level
E^2*dN/dE = 2*10^-9 cm^-2s^-1GeV. A diffuse E-2 flux would be detectable at a
minimum strength of E^2*dN/dE = 1*10^-8 cm^-2s^-1sr^-1GeV. A gamma-ray burst
model following the formulation of Waxman and Bahcall would result in a 5-sigma
effect after the observation of 200 bursts in coincidence with satellite
observations of the gamma-rays.Comment: 33 pages, 13 figures, 6 table
Features of Muon Arrival Time Distributions of High Energy EAS at Large Distances From the Shower Axis
In view of the current efforts to extend the KASCADE experiment
(KASCADE-Grande) for observations of Extensive Air Showers (EAS) of primary
energies up to 1 EeV, the features of muon arrival time distributions and their
correlations with other observable EAS quantities have been scrutinised on
basis of high-energy EAS, simulated with the Monte Carlo code CORSIKA and using
in general the QGSJET model as generator. Methodically various correlations of
adequately defined arrival time parameters with other EAS parameters have been
investigated by invoking non-parametric methods for the analysis of
multivariate distributions, studying the classification and misclassification
probabilities of various observable sets. It turns out that adding the arrival
time information and the multiplicity of muons spanning the observed time
distributions has distinct effects improving the mass discrimination. A further
outcome of the studies is the feature that for the considered ranges of primary
energies and of distances from the shower axis the discrimination power of
global arrival time distributions referring to the arrival time of the shower
core is only marginally enhanced as compared to local distributions referring
to the arrival of the locally first muon.Comment: 24 pages, Journal Physics G accepte
The Calcitonin and Glucocorticoids Combination: Mechanistic Insights into Their Class-Effect Synergy in Experimental Arthritis
PMCID: PMC3564948This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Neutrino Interactions at Ultrahigh Energies
We report new calculations of the cross sections for deeply inelastic
neutrino-nucleon scattering at neutrino energies between 10^{9}\ev and
10^{21}\ev. We compare with results in the literature and assess the
reliability of our predictions. For completeness, we briefly review the cross
sections for neutrino interactions with atomic electrons, emphasizing the role
of the -boson resonance in interactions for neutrino
energies in the neighborhood of 6.3\pev. Adopting model predictions for
extraterrestrial neutrino fluxes from active galactic nuclei, gamma-ray
bursters, and the collapse of topological defects, we estimate event rates in
large-volume water \v{C}erenkov detectors and large-area ground arrays.Comment: 32 pages, 11 figures, uses RevTeX and boxedep
Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire, and Cappuccino
The actin nucleation factors Spire and Cappuccino regulate the onset of ooplasmic
streaming in Drosophila1-5. Although this streaming event is microtubule-based, actin
assembly is required for its timing. It is not understood how the interaction of
microtubules and microfilaments is mediated in this context. Here we demonstrate that
Cappuccino and Spire have microtubule and microfilament crosslinking activity. The spire
locus encodes several distinct protein isoforms (SpireA, SpireC, and SpireD). SpireD was
recently shown to nucleate actin, but the activity of the other isoforms has not been
addressed. We find that SpireD does not have crosslinking activity, while SpireC is a
potent crosslinker. We show that SpireD binds to Cappuccino and inhibits Factin/
microtubule crosslinking, and activated Rho1 abolishes this inhibition, establishing a
mechanistic basis for the regulation of Capu and Spire activity. We propose that Rho1,
cappuccino and spire are elements of a conserved developmental cassette that is capable of
directly mediating crosstalk between microtubules and microfilaments
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