Fearsome Creatures of the Lumberwoods: With a Few Desert and Mountain Beasts

Every lumber region has its lore. Thrilling tales of adventure are told in camp wherever the logger has entered the wilderness. The lumber jack is an imaginative being, and a story loses none of its interest as it is carried and repeated from one camp to another. Stories which I know to have originated on the Penobscot and the Kennebec are told, somewhat strengthened and improved, in the redwood camps of Humboldt Bay. Yarns originating among the river drivers of the Ottawa, the St. Croix, and the upper Mississippi are respun to groups of listening loggers on Vancouver Island. But every lumber district has its own peculiar tales. Some have their songs also, and nearly all have mysterious stories or vague rumors of dreadful beasts with which to regale newcomers and frighten people unfamiliar with the woods. Much has been written concerning the lumber jack and his life; some of his songs, rough but full of the sentiment of his exciting vocation, have been commemorated, but, so far as I know, very few of the strange creatures of his imagination have ever been described by the naturalist or sketched by the artist. The lumber regions are contracting. Stretches of forest that once seemed boundless are all but gone, and many a stream is quiet that once ran full of logs and echoed to the song of the river driver. Some say that the old type of logger himself is becoming extinct. It is my purpose in this little book to preserve at least a description and and sketch of some of the interesting animals which he has originated. Beasts described and pictured include: Hugag, Gumberoo, Roperite, Snoligoster, Leprocaun, Funeral Mountain Terrashot, Slide-rock Bolter, Tote-road Shagamaw, Wapaloosie, Cactus Cat, Hodag, Squonk, Whirling Whimpus, Agropelter, Splinter Cat, Snow Wasset, Central American Whintosser, Billdad, Tripodero, & Hyampom Hog Bear

Automatic mode tracking for flight dynamic analysis using a spanning algorithm

Identifying and tracking dynamic modes in a multi-dimensional parameter space is a problem that presents itself in many engineering disciplines. In a flight dynamics context, the dynamic modes refer to the modes of motion obtained from a linearisation of the aircraft system about a known operating point. Typically dynamic results derived from these linear models are unsorted, where mode indices are unrelated from one operating point to the next. When varying the parameters, or in this case operating point, difficulties in automating the process of relating modes from a linear system derived at one parameter set to the next exists. This paper builds on the work in tracking modes in a structural context, using the Modal Assurance Criterion (MAC) to numerically relate modes from two comparable linear systems. The (MAC) is deployed within a spanning algorithm to discover and identify all modes within all conditions, with their relationship to adjacent/neighbouring conditions. This is tested on a 1-, 2- and 3-dimensional parameter space, twelve state system

Low-loss singlemode PECVD silicon nitride photonic wire waveguides for 532-900 nm wavelength window fabricated within a CMOS pilot line

PECVD silicon nitride photonic wire waveguides have been fabricated in a CMOS pilot line. Both clad and unclad single mode wire waveguides were measured at lambda = 532, 780, and 900 nm, respectively. The dependence of loss on wire width, wavelength, and cladding is discussed in detail. Cladded multimode and singlemode waveguides show a loss well below 1 dB/cm in the 532-900 nm wavelength range. For singlemode unclad waveguides, losses < 1 dB/cm were achieved at lambda = 900 nm, whereas losses were measured in the range of 1-3 dB/cm for lambda = 780 and 532 nm, respectively

Life Cycle of Multi Technology Machine Tools – Modularization and Integral Design

AbstractFor reasons of high flexibility but still maximum productivity, machine tools integrating various production technologies have recently received particular attention. Combining and integrating multiple manufacturing techniques into one single system in early stages of the product emergence process is challenging. To keep the effort for implementation to a minimum, an initiation already in the concept phase is being actively pursued. Design guidelines are currently investigated based on the examination of different technology combinations.This approach focuses on systematic conceptual design for such hybrid machine technologies. Product architectures are used to describe the modularity and create a specific delimitation for standardization. Reference product architectures for Multi Technology Machine Tools (MTMT) carry high potential for saving expenses in product development. The main emphasis is on technology and system integration. A technological similarity assessment of the single processes involved forms the basis of this approach to assure potential for synergies. Monetary aspects in early stages of product development are considered. Based on the analysis a generic system model is connected with general product architectures for MTMT.The method introduced is validated by a Multi-Technology Machining Centre with two simultaneously usable workspaces integrating a milling spindle and two laser processing units. The research undertaken is part of the Cluster of Excellence “Integrative Production Technology for High-Wage Countries” and has been funded by German Research Foundation (DFG)

Weak signal detection based on two dimensional stochastic resonance

The analysis of vibrations from rotating machines gives information about their faults. From the signal processing perspective a significant problem is the detection of weak signals embedded in strong noise. Stochastic resonance (SR) is a mechanism where noise is not suppressed but exploited to trigger the synchronization of a non-linear system and in its one-dimensional form has been recently applied to vibration analysis. This paper focuses on the use of SR in a two-dimensional system of gradient type for detection of weak signals submerged in Gaussian noise. Comparing the traditional one-dimensional system and the two-dimensional used here, this paper shows that the latter can offer a more sensitive means of detection. An alternative metric is proposed to assess the output signal quality, requiring no a priori knowledge of the signal to be detected, and it is shown to offer similar results to the more conventional signal-to-noise ratio

The QICKD study protocol: a cluster randomised trial to compare quality improvement interventions to lower systolic BP in chronic kidney disease (CKD) in primary care.

BACKGROUND: Chronic kidney disease (CKD) is a relatively newly recognised but common long-term condition affecting 5 to 10% of the population. Effective management of CKD, with emphasis on strict blood pressure (BP) control, reduces cardiovascular risk and slows the progression of CKD. There is currently an unprecedented rise in referral to specialist renal services, which are often located in tertiary centres, inconvenient for patients, and wasteful of resources. National and international CKD guidelines include quality targets for primary care. However, there have been no rigorous evaluations of strategies to implement these guidelines. This study aims to test whether quality improvement interventions improve primary care management of elevated BP in CKD, reduce cardiovascular risk, and slow renal disease progression DESIGN: Cluster randomised controlled trial (CRT) METHODS: This three-armed CRT compares two well-established quality improvement interventions with usual practice. The two interventions comprise: provision of clinical practice guidelines with prompts and audit-based education. The study population will be all individuals with CKD from general practices in eight localities across England. Randomisation will take place at the level of the general practices. The intended sample (three arms of 25 practices) powers the study to detect a 3 mmHg difference in systolic BP between the different quality improvement interventions. An additional 10 practices per arm will receive a questionnaire to measure any change in confidence in managing CKD. Follow up will take place over two years. Outcomes will be measured using anonymised routinely collected data extracted from practice computer systems. Our primary outcome measure will be reduction of systolic BP in people with CKD and hypertension at two years. Secondary outcomes will include biomedical outcomes and markers of quality, including practitioner confidence in managing CKD. A small group of practices (n = 4) will take part in an in-depth process evaluation. We will use time series data to examine the natural history of CKD in the community. Finally, we will conduct an economic evaluation based on a comparison of the cost effectiveness of each intervention. CLINICAL TRIALS REGISTRATION: ISRCTN56023731. ClinicalTrials.gov identifier

A phase I and pharmacokinetic study of novel taxane BMS-188797 and cisplatin in patients with advanced solid tumours

This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m−2 DL), combined with cisplatin (standard dose 75 mg m−2). In 16 patients with advanced malignancies treated, one patient experienced dose-limiting febrile neutropenia, sepsis and severe colitis at the 150 mg m−2 DL; at the 110 mg m−2 DL one episode of dose-limiting grade 3 diarrhoea/nausea occurred. Grade 3/4 haematological toxicities were leucopenia/neutropenia; grade 3 nonhaematological toxicities were neuropathy, nausea, diarrhoea and stomatits. Objective response was seen in four patients, with three complete remissions in ovarian and cervical cancer patients. Pharmacokinetics of BMS-188797 appeared linear through the 110 mg m−2, but not through the 150 mg m−2 DL. The mean±SD values for clearance, distribution volume at steady state and terminal half-life during cycle 1 were 317±60 ml min−1 m−2, 258±96 l m−2 and 30.8±7.7 h, respectively. The maximum tolerated and recommended phase II dose for BMS-188797 was 110 mg m−2 (1-h infusion, every 3 weeks) combined with cisplatin 75 mg m−2

Pegfilgrastim ± ciprofloxacin for primary prophylaxis with TAC (docetaxel/doxorubicin/cyclophosphamide) chemotherapy for breast cancer. Results from the GEPARTRIO study

Background: TAC (docetaxel/doxorubicin/cyclophosphamide) is associated with high incidences of grade 4 neutropenia and febrile neutropenia (FN). This analysis compared the efficacies of four regimens for primary prophylaxis of FN and related toxic effects in breast cancer patients receiving neoadjuvant TAC. Patients and methods: Patients with stage T2-T4 primary breast cancer were scheduled to receive 6-8 cycles of TAC. Primary prophylaxis was: ciprofloxacin 500 mg orally twice daily on days 5-14 (n = 253 patients; 1478 cycles), daily granulocyte colony-stimulating factor (G-CSF) (filgrastim 5 μg/kg/day or lenograstim 150 μg/m2/day) on days 5-10 (n = 377; 2400 cycles), pegfilgrastim 6 mg on day 2 (n = 305; 1930 cycles), or pegfilgrastim plus ciprofloxacin (n = 321; 1890 cycles). Results: Pegfilgrastim with/without ciprofloxacin was significantly more effective than daily G-CSF or ciprofloxacin in preventing FN (5% and 7% versus 18% and 22% of patients; all P < 0.001), grade 4 neutropenia, and leukopenia. Pegfilgrastim plus ciprofloxacin completely prevented first cycle FN (P < 0.01 versus pegfilgrastim alone) and fatal neutropenic events. Conclusion: Ciprofloxacin alone, or daily G-CSF from day 5-10 (as in common practice), provided suboptimal protection against FN and related toxic effects in patients receiving TAC. Pegfilgrastim was significantly more effective in this setting, especially if given with ciprofloxaci