467 research outputs found
Bogoliubov Coefficients of 2D Charged Black Holes
We exactly calculate the thermal distribution and temperature of Hawking
radiation for a two-dimensional charged dilatonic black hole after it has
settled down to an "equilibrium" state. The calculation is carried out using
the Bogoliubov coefficients. The background of the process is furnished by a
preexisting black hole and not by collapsing matter as considered by Giddings
and Nelson for the case of a Schwarzschild black hole. Furthermore, the
vanishing of the temperature and/or the Hawking radiation in the extremal case
is obtained as a regular limit of the general case.Comment: 9 pages, 1 eps figur
On dynamical mass generation in three dimensional supersymmetric U(1) gauge field theory
We investigate and contrast the non-perturbative infra red structure of N=1
and N=2 supersymmetric non-compact U(1) gauge field theory in three space-time
dimensions with N matter flavours. We study the Dyson-Schwinger equations in a
general gauge using superfield formalism; this ensures that supersymmetry is
kept manifest, though leads to spurious infra red divergences which we have to
avoid carefully. In the N=1 case the superfield formalism allows us to choose a
vertex which satisfies the U(1) Ward identity exactly, and we find the expected
critical behaviour in the wavefunction renormalization and strong evidence for
the existence of a gauge independent dynamically generated mass, but with no
evidence for a critical flavour number. We study the N=2 model by dimensional
reduction from four dimensional N=1 electrodynamics, and we refine the old
gauge dependence argument that there is no dynamical mass generation. We
recognize that the refinement only holds after dimensional reduction.Comment: 32 pages RevTeX; 3 axodraw figures include
Gauge Coupling Instability and Dynamical Mass Generation in N=1 Supersymmetric QED(3)
Using superfield Dyson-Schwinger equations, we compute the infrared dynamics
of the semi-amputated full vertex, corresponding to the effective running gauge
coupling, in N-flavour {\mathcal N}=1 supersymmetric QED(3). It is shown that
the presence of a supersymmetry-preserving mass for the matter multiplet
stabilizes the infrared gauge coupling against oscillations present in the
massless case, and we therefore infer that the massive vacuum is thus selected
at the level of the (quantum) effective action. We further demonstrate that
such a mass can indeed be generated dynamically in a self-consistent way by
appealing to the superfield Dyson-Schwinger gap equation for the full matter
propagator.Comment: 14 pages ReVTeX; four axodraw figures incorporate
Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker
Human kallikrein 6 protein is a newly discovered human kallikrein. We determined the amount of human kallikrein 6 in extracts of 182 ovarian tumours and correlated specific activity (ngâhK6âmgâ1 total protein) with clinicopathological variables documented at the time of surgical excision and with outcome (progression free survival, overall survival) monitored over a median interval of 62 months. Thirty per cent of the tumours were positive for human kallikrein 6 (>35âng hK6âmgâ1 total protein). Human kallikrein 6-specific immunohistochemical staining of four ovarian tissues that included benign, borderline and malignant lesions indicated a cytoplasmic location of human kallikrein 6 in tumour cells of epithelial origin, although the intensity of staining was variable. Tumour human kallikrein 6 (ngâhK6âmgâ1 total protein) was higher in late stage disease, serous histotype, residual tumour >1âcm and suboptimal debulking (>1âcm) (P<0.05). Univariate analysis revealed that patients with tumour human kallikrein 6 positive specific activity were more likely to suffer progressive disease and to die (hazard ratio 1.71 (P=0.015) and 1.88 (P=0.022), respectively). Survival curves demonstrated the same (P=0.013 and 0.019, respectively). Multivariate analysis revealed that human kallikrein 6 positivity was retained as an independent prognostic variable in several subgroups of patients, namely those with (low) grade I and II tumours (hazard ratio progression free survival 4.3 (P=0.027) and overall survival 4.1 (P=0.023)) and those with optimal debulking (hazard ratio progression free survival 3.8 (P=0.019) and overall survival 5.6 (P=0.011)). We conclude that tumour kallikrein 6 protein levels have utility as an independent adverse prognostic marker in a subgroup of ovarian cancer patients with otherwise apparently good prognosis
Activation and enzymatic characterization of recombinant human kallikrein 8.
Human kallikrein 8 (hK8), whose gene was originally cloned as the human ortholog of a mouse brain protease, is known to be associated with diseases such as ovarian cancer and Alzheimer's disease. Recombinant human pro-kallikrein 8 was activated with lysyl endopeptidase-conjugated beads. Amino-terminal sequencing of the activated enzyme demonstrated the cleavage of a 9-aa propeptide from the pro-enzyme. The substrate specificity of activated hK8 was characterized using synthetic fluorescent substrates. hK8 showed trypsin-like specificity, as predicted from sequence analysis and enzymatic characterization of the mouse ortholog. All synthetic substrates tested containing either arginine or lysine at P1 position were cleaved by hK8. The highest kcat/Km value of 20x10(3)M-1 s-1 was observed with Boc-Val-Pro-Arg-7-amido-4-methylcoumarin. The activity of hK8 was inhibited by antipain, chymostatin, and leupeptin. The concentration for 50% inhibition by the best inhibitor, antipain, was 0.46 microM. The effect of different metal ions on the enzyme activity was analyzed. Whereas Na+ had no effect on hK8 activity, Ni2+ and Zn2+ decreased the activity and Ca2+, Mg2+, and K+ had a stimulatory effect. Ca2+ was the best activator, with an optimal concentration of approximately 10 microM
On the Stability of the Classical Vacua in a Minimal SU(5) 5-D Supergravity Model
We consider a five-dimensional supergravity model with SU(5) gauge symmetry
and the minimal field content. Studying the arising scalar potential we find
that the gauging of the symmetry of the five-dimensional supergravity
causes instabilities. Lifting the instabilities the vacua are of Anti-de-Sitter
type and SU(5) is broken along with supersymmetry. Keeping the
ungauged the potential has flat directions along which supersymmetry is
unbroken.Comment: 24 pages, 2 figure
Phantom with Born-Infield type Lagrangian
Recent analysis of the observation data indicates that the equation of state
of the dark energy might be smaller than -1, which leads to the introduction of
phantom models featured by its negative kinetic energy to account for the
regime of equation of state . In this paper, we generalize the idea to
the Born-Infield type Lagrangian with negative kinetic energy term and give the
condition for the potential, under which the late time attractor solution
exists and also analyze a viable cosmological model in such a scheme.Comment: 13 pages, 6 figures, Reference updated, the final version will be
published in Phys. Rev.
Cosmological Evolution of a Brane Universe in a Type 0 String Background
We study the cosmological evolution of a D3-brane Universe in a type 0 string
background. We follow the brane-universe along the radial coordinate of the
background and we calculate the energy density which is induced on the brane
because of its motion in the bulk. We find that for some typical values of the
parameters and for a particular range of values of the scale factor of the
brane-universe, the effective energy density is dominated by a term
proportional to indicating a slow varying inflationary
phase. For larger values of the scale factor the effective energy density takes
a constant value and the brane-universe enters its usual inflationary period.Comment: 25 pages,1 figure,LaTex file,final version to appear in Phys. Rev.
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