919 research outputs found
Identification of the major cause of endemically poor mobilities in SiC/SiO2 structures
Materials with good carrier mobilities are desired for device applications,
but in real devices the mobilities are usually limited by the presence of
interfaces and contacts. Mobility degradation at semiconductor-dielectric
interfaces is generally attributed to defects at the interface or inside the
dielectric, as is the case in Si/SiO2 structures, where processing does not
introduce detrimental defects in the semiconductor. In the case of SiC/SiO2
structures, a decade of research focused on reducing or passivating interface
and oxide defects, but the low mobilities have persisted. By invoking
theoretical results and available experimental evidence, we show that thermal
oxidation generates carbon di-interstitial defects inside the semiconductor
substrate and that they are a major cause of the poor mobility in SiC/SiO2
structures
Stress, alcohol and infection during early development: a brief review of common outcomes and mechanisms.
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during the early stages of life, such as infancy or adolescence, can induce adaptations in multiple physiological systems, including the reproductive axis, the hypothalamic‐pituitary‐adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioural responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (perinatal, juvenile, adolescent periods) and how the developmental timing of early‐life stress confers unique physiological adaptations that may persist across the lifespan. In doing so, we emphasise how intrinsic sex differences in the stress response might contribute to sex‐specific vulnerabilities, the molecular processes underlying stress in the adult, and potential therapeutic interventions to mitigate the effects of early stage stress, including the novel molecular mechanism of SUMOylation as a possible key target of HPA regulation during early‐life stress.Fil: Surkin, Pablo Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Breanhouse H. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Deak T. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Liberman AC. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentin
The CCFM Monte Carlo generator CASCADE 2.2.0
CASCADE is a full hadron level Monte Carlo event generator for ep, \gamma p
and p\bar{p} and pp processes, which uses the CCFM evolution equation for the
initial state cascade in a backward evolution approach supplemented with off -
shell matrix elements for the hard scattering. A detailed program description
is given, with emphasis on parameters the user wants to change and variables
which completely specify the generated events
Multi-gluon helicity amplitudes with one off-shell leg within high energy factorization
Basing on the Slavnov-Taylor identities, we derive a new prescription to
obtain gauge invariant tree-level scattering amplitudes for the process g*g->Ng
within high energy factorization. Using the helicity method, we check the
formalism up to several final state gluons, and we present analytical formulas
for the the helicity amplitudes for N=2. We also compare the method with
Lipatov's effective action approach.Comment: 25 pages, quite a few figures, an appendix added, typos correcte
Determining the 7Li(n,gamma) cross section via Coulomb dissociation of 8Li
The applicability of Coulomb dissociation reactions to determine the cross
section for the inverse neutron capture reaction was explored using the
reaction 8Li(gamma,n)7Li. A 69.5 MeV/nucleon 8Li beam was incident on a Pb
target, and the outgoing neutron and 7Li nucleus were measured in coincidence.
The deduced (n,gamma) excitation function is consistent with data for the
direct capture reaction 7Li(n,gamma)8Li and with low-energy effective field
theory calculations.Comment: Accepted for publication in Phys. Rev.
Dependence of the flux creep activation energy on current density and magnetic field for MgB2 superconductor
Systematic ac susceptibility measurements have been performed on a MgB
bulk sample. We demonstrate that the flux creep activation energy is a
nonlinear function of the current density , indicating a
nonlogarithmic relaxation of the current density in this material. The
dependence of the activation energy on the magnetic field is determined to be a
power law , showing a steep decline in the activation
energy with the magnetic field, which accounts for the steep drop in the
critical current density with magnetic field that is observed in MgB. The
irreversibility field is also found to be rather low, therefore, the pinning
properties of this new material will need to be enhanced for practical
applications.Comment: 11 pages, 6 figures, Revtex forma
Exome Sequencing Reveals a Phenotype Modifying Variant inZNF528in Primary Osteoporosis With aCOL1A2Deletion
We studied a family with severe primary osteoporosis carrying a heterozygous p.Arg8Phefs*14 deletion in COL1A2, leading to haploinsufficiency. Three affected individuals carried the mutation and presented nearly identical spinal fractures but lacked other typical features of either osteogenesis imperfecta or Ehlers-Danlos syndrome. Although mutations leading to haploinsufficiency in COL1A2 are rare, mutations in COL1A1 that lead to less protein typically result in a milder phenotype. We hypothesized that other genetic factors may contribute to the severe phenotype in this family. We performed whole-exome sequencing in five family members and identified in all three affected individuals a rare nonsense variant (c.1282C > T/p.Arg428*, rs150257846) in ZNF528. We studied the effect of the variant using qPCR and Western blot and its subcellular localization with immunofluorescence. Our results indicate production of a truncated ZNF528 protein that locates in the cell nucleus as per the wild-type protein. ChIP and RNA sequencing analyses on ZNF528 and ZNF528-c.1282C > T indicated that ZNF528 binding sites are linked to pathways and genes regulating bone morphology. Compared with the wild type, ZNF528-c.1282C > T showed a global shift in genomic binding profile and pathway enrichment, possibly contributing to the pathophysiology of primary osteoporosis. We identified five putative target genes for ZNF528 and showed that the expression of these genes is altered in patient cells. In conclusion, the variant leads to expression of truncated ZNF528 and a global change of its genomic occupancy, which in turn may lead to altered expression of target genes. ZNF528 is a novel candidate gene for bone disorders and may function as a transcriptional regulator in pathways affecting bone morphology and contribute to the phenotype of primary osteoporosis in this family together with the COL1A2 deletion. (c) 2020 The Authors.Journal of Bone and Mineral Researchpublished by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).Peer reviewe
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