343 research outputs found

    A Cyclic Analogue of Stanley's Shuffle Theorem

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    We introduce the cyclic major index of a cycle permutation and give a bivariate analogue of enumerative formula for the cyclic shuffles with a given cyclic descent numbers due to Adin, Gessel, Reiner and Roichman, which can be viewed as a cyclic analogue of Stanley's Shuffle Theorem. This gives an answer to a question of Adin, Gessel, Reiner and Roichman, which has been posed by Domagalski, Liang, Minnich, Sagan, Schmidt and Sietsema again.Comment: 7 pages. We thank Bruce Sagan for providing useful comments and relevant references for the earlier versio

    Alpine Space Prospective Study. Sustainable territorial development in the Alpine Space: Towards long term transnational cooperation

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    This "Prospective Study" argues that a long term transnational cooperation will be able to pursue the sustainable territorial development in the Alpine Space only at the condition of a substantial improvement of the current experience. This regards an increased awareness of the complexity of issues and challenges currently at stake in the Alpine area but especially, in this light, the capacity of involving all relevant institutional and socioeconomic stakeholders in the building of shared transnational strategie

    Alpine Space Prospective Study. Sustainable territorial development in the Alpine Space: Towards long term transnational cooperation

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    This "Prospective Study" argues that a long term transnational cooperation will be able to pursue the sustainable territorial development in the Alpine Space only at the condition of a substantial improvement of the current experience. This regards an increased awareness of the complexity of issues and challenges currently at stake in the Alpine area but especially, in this light, the capacity of involving all relevant institutional and socioeconomic stakeholders in the building of shared transnational strategies

    DPP6 regulation of dendritic morphogenesis impacts hippocampal synaptic development

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    Dipeptidyl-peptidase 6 is an auxiliary subunit of Kv4-mediated A-type K+ channels that, in addition to enhancing channel surface expression, potently accelerates their kinetics. The dipeptidyl-peptidase 6 gene has been associated with a number of human central nervous system disorders including autism spectrum disorders and schizophrenia. Here we employ knockdown and genetic deletion of dipeptidyl-peptidase 6 to reveal its importance for the formation and stability of dendritic filopodia during early neuronal development. We find that the hippocampal neurons lacking dipeptidyl-peptidase 6 show a sparser dendritic branching pattern along with fewer spines throughout development and into adulthood. In electrophysiological and imaging experiments, we show that these deficits lead to fewer functional synapses and occur independently of the potassium channel subunit Kv4.2. We report that dipeptidyl-peptidase 6 interacts with a filopodia-associated myosin as well as with fibronectin in the extracellular matrix. dipeptidyl-peptidase 6 therefore has an unexpected but important role in cell adhesion and motility, impacting the hippocampal synaptic development and function

    First observation of two hyperfine transitions in antiprotonic He-3

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    We report on the first experimental results for microwave spectroscopy of the hyperfine structure of antiprotonic He-3. Due to the helium nuclear spin, antiprotonic He-3 has a more complex hyperfine structure than antiprotonic He-4 which has already been studied before. Thus a comparison between theoretical calculations and the experimental results will provide a more stringent test of the three-body quantum electrodynamics (QED) theory. Two out of four super-super-hyperfine (SSHF) transition lines of the (n,L)=(36,34) state were observed. The measured frequencies of the individual transitions are 11.12559(14) GHz and 11.15839(18) GHz, less than 1 MHz higher than the current theoretical values, but still within their estimated errors. Although the experimental uncertainty for the difference of these frequencies is still very large as compared to that of theory, its measured value agrees with theoretical calculations. This difference is crucial to be determined because it is proportional to the magnetic moment of the antiproton.Comment: 8 pages, 6 figures, just published (online so far) in Physics Letters

    What Future for LEADER as a Catalyst of Social Innovation?

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    The LEADER Approach was initially designed to promote innovation in European rural areas by sustaining a bottom-up approach to local development. Nowadays the LEADER Approach includes elements that are generally considered to support social innovation. Classical features of the LEADER Approach \u2013 for example, area-based development strategies and cooperation and networking \u2013 are considered catalysts of social innovation as well. By drawing on key elements which support social innovation, the chapter discusses the future role of the LEADER Approach and Local Action Groups, and debates the challenges and potentials of the new rural development policy within emerging social, environmental and economic needs

    Muonic hydrogen cascade time and lifetime of the short-lived 2S2S state

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    Metastable 2S{2S} muonic-hydrogen atoms undergo collisional 2S{2S}-quenching, with rates which depend strongly on whether the ÎŒp\mu p kinetic energy is above or below the 2S→2P{2S}\to {2P} energy threshold. Above threshold, collisional 2S→2P{2S} \to {2P} excitation followed by fast radiative 2P→1S{2P} \to {1S} deexcitation is allowed. The corresponding short-lived ÎŒp(2S)\mu p ({2S}) component was measured at 0.6 hPa H2\mathrm{H}_2 room temperature gas pressure, with lifetime τ2Sshort=165−29+38\tau_{2S}^\mathrm{short} = 165 ^{+38}_{-29} ns (i.e., λ2Squench=7.9−1.6+1.8×1012s−1\lambda_{2S}^\mathrm{quench} = 7.9 ^{+1.8}_{-1.6} \times 10^{12} \mathrm{s}^{-1} at liquid-hydrogen density) and population Ï”2Sshort=1.70−0.56+0.80\epsilon_{2S}^\mathrm{short} = 1.70^{+0.80}_{-0.56} % (per ÎŒp\mu p atom). In addition, a value of the ÎŒp\mu p cascade time, TcasÎŒp=(37±5)T_\mathrm{cas}^{\mu p} = (37\pm5) ns, was found.Comment: 4 pages, 3 figure

    The proton radius puzzle

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    High-precision measurements of the proton radius from laser spectroscopy of muonic hydrogen demonstrated up to six standard deviations smaller values than obtained from electron-proton scattering and hydrogen spectroscopy. The status of this discrepancy, which is known as the proton radius puzzle will be discussed in this paper, complemented with the new insights obtained from spectroscopy of muonic deuterium.Comment: Moriond 2017 conference, 8 pages, 4 figure

    Improved Study of the Antiprotonic Helium Hyperfine Structure

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    We report the initial results from a systematic study of the hyperfine (HF) structure of antiprotonic helium (n,l) = (37,~35) carried out at the Antiproton Decelerator (AD) at CERN. We performed a laser-microwave-laser resonance spectroscopy using a continuous wave (cw) pulse-amplified laser system and microwave cavity to measure the HF transition frequencies. Improvements in the spectral linewidth and stability of our laser system have increased the precision of these measurements by a factor of five and reduced the line width by a factor of three compared to our previous results. A comparison of the experimentally measured transition frequencies with three body QED calculations can be used to determine the antiproton spin magnetic moment, leading towards a test of CPT invariance.Comment: 14 pages 9 figure

    Rettungsdienststrukturen neu denken – Ergebnisse der Expertenworkshops „Logistik in der prĂ€klinischen Notfallversorgung“ [Rethinking emergency medical services (EMS)—results of an interdisciplinary expert panel on logistics in EMS]

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    Die rettungsdienstliche Struktur in Deutschland stellt eine Versorgung auf sehr hohem Niveau sicher. Dennoch ist es notwendig, die vorhandenen Strukturen zu ĂŒberdenken und fĂŒr die Zukunft zu hĂ€rten. Nicht nur vor dem Hintergrund stetig steigender Einsatzzahlen, sondern auch wegen der Herausforderungen der Personalgewinnung und der Alterung der Bevölkerung sollten Reformen im Rettungsdienst dringend angegangen werden. Hier kann der Rettungsdienst viel von der Mathematik und gerade vom Bereich „operations research“ lernen. Dieser Fachbereich beschĂ€ftigt sich explizit mit der Verbesserung von logistischen Herausforderungen, die der Rettungsdienst ohne Frage ist. In der vorliegenden Arbeit berichten die Autorinnen und Autoren ĂŒber die ersten Ergebnisse zweier Workshops zum Thema „Logistik in der prĂ€klinischen Versorgung“ und möchten damit die Diskussion im Rettungsdienst auf breiter Basis anregen sowie Verbesserungspotenziale und Herausforderungen fĂŒr die verschiedenen Akteure in der prĂ€klinischen Behandlung herausarbeiten, aber auch erste Ideen zu LösungsansĂ€tzen liefern
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