Centrifugal Breakout of Magnetically Confined Line-Driven Stellar Winds

We present 2D MHD simulations of the radiatively driven outflow from a rotating hot star with a dipole magnetic field aligned with the star's rotation axis. We focus primarily on a model with moderately rapid rotation (half the critical value), and also a large magnetic confinement parameter, $\eta_{\ast} \equiv B_{\ast}^2 R_{\ast}^{2} / \dot{M} V_{\infty} = 600$. The magnetic field channels and torques the wind outflow into an equatorial, rigidly rotating disk extending from near the Kepler corotation radius outwards. Even with fine-tuning at lower magnetic confinement, none of the MHD models produce a stable Keplerian disk. Instead, material below the Kepler radius falls back on to the stellar surface, while the strong centrifugal force on material beyond the corotation escape radius stretches the magnetic loops outwards, leading to episodic breakout of mass when the field reconnects. The associated dissipation of magnetic energy heats material to temperatures of nearly $10^{8}$K, high enough to emit hard (several keV) X-rays. Such \emph{centrifugal mass ejection} represents a novel mechanism for driving magnetic reconnection, and seems a very promising basis for modeling X-ray flares recently observed in rotating magnetic Bp stars like $\sigma$ Ori E.Comment: 5 pages, 3 figures, accepted by ApJ

Phase transition in a log-normal Markov functional model

We derive the exact solution of a one-dimensional Markov functional model with log-normally distributed interest rates in discrete time. The model is shown to have two distinct limiting states, corresponding to small and asymptotically large volatilities, respectively. These volatility regimes are separated by a phase transition at some critical value of the volatility. We investigate the conditions under which this phase transition occurs, and show that it is related to the position of the zeros of an appropriately defined generating function in the complex plane, in analogy with the Lee-Yang theory of the phase transitions in condensed matter physics.Comment: 9 pages, 5 figures. v2: Added asymptotic expressions for the convexity-adjusted Libors in the small and large volatility limits. v3: Added one reference. Final version to appear in Journal of Mathematical Physic

A Landslide Climate Indicator from Machine Learning

In order to create a Landslide Hazard Index, we accessed rain, snow, and a dozen other variables from the National Climate Assessment Land Data Assimilation System. These predictors were converted to probabilities of landslide occurrence with XGBoost, a major machine-learning tool. The model was fitted with thousands of historical landslides from the Pacific Northwest Landslide Inventory (PNLI)

The Effect of Porosity on X-ray Emission Line Profiles from Hot-Star Winds

We investigate the degree to which the nearly symmetric form of X-ray emission lines seen in Chandra spectra of early-type supergiant stars could be explained by a possibly porous nature of their spatially structured stellar winds. Such porosity could effectively reduce the bound-free absorption of X-rays emitted by embedded wind shocks, and thus allow a more similar transmission of red- vs. blue-shifted emission from the back vs. front hemispheres. For a medium consisting of clumps of size l and volume filling factor f, in which the `porosity length' h=l/f increases with local radius as h = h' r, we find that a substantial reduction in wind absorption requires a quite large porosity scale factor h' > 1, implying large porosity lengths h > r. The associated wind structure must thus have either a relatively large scale l~ r, or a small volume filling factor f ~ l/r << 1, or some combination of these. The relatively small-scale, moderate compressions generated by intrinsic instabilities in line-driving seem unlikely to give such large porosity lengths, leaving again the prospect of instead having to invoke a substantial (ca. factor 5) downward revision in assumed mass-loss rates.Comment: 6 pages in apj-emulate; 3 figures; submitted to Ap

Effects of Inventory Bias on Landslide Susceptibility Calculations

Many landslide inventories are known to be biased, especially inventories for large regions such as Oregon's SLIDO or NASA's Global Landslide Catalog. These biases must affect the results of empirically derived susceptibility models to some degree. We evaluated the strength of the susceptibility model distortion from postulated biases by truncating an unbiased inventory. We generated a synthetic inventory from an existing landslide susceptibility map of Oregon, then removed landslides from this inventory to simulate the effects of reporting biases likely to affect inventories in this region, namely population and infrastructure effects. Logistic regression models were fitted to the modified inventories. Then the process of biasing a susceptibility model was repeated with SLIDO data. We evaluated each susceptibility model with qualitative and quantitative methods. Results suggest that the effects of landslide inventory bias on empirical models should not be ignored, even if those models are, in some cases, useful. We suggest fitting models in well-documented areas and extrapolating across the study region as a possible approach to modeling landslide susceptibility with heavily biased inventories

The male of the species: a profile of men in nursing

Aim: To establish a profile of men in nursing in Western Australia and explore the perception of men in nursing from the perspective of male and female nurses. Background: A project team, including some of the current authors, produced a YouTube video and DVD about men in nursing which led to further inquiry on this topic. Design: The study employed a non-experimental, comparative, descriptive research design focused on a quantitative methodology, using an online survey in early 2014. Method: A convenience sample incorporated registered and enrolled nurses and midwives in Western Australia. Findings: The range of data included demographic information and the respondents’ perceptions of men in nursing were collected. Findings indicated that the main reasons for choosing a career in nursing or midwifery were similar for both genders. Common mis-perceptions of men in nursing included: most male nurses are gay; men are not suited to nursing and men are less caring and compassionate than women. Suggestions to promote nursing to men included: nurses are highly skilled professionals; there is the potential to make a difference for patients; nursing offers stable employment, professional diversity and opportunities for team work. There is a diminished awareness of opportunities for men in nursing and negative stereotypes related to men in nursing persist. Conclusion: The study produced recommendations which included: using the right message to target the recruitment for men and promoting a more realistic understanding of the profile and perception of men in nursing

Test of Guttmann and Enting's conjecture in the eight-vertex model

We investigate the analyticity property of the partially resummed series expansion(PRSE) of the partition function for the eight-vertex model. Developing a graphical technique, we have obtained a first few terms of the PRSE and found that these terms have a pole only at one point in the complex plane of the coupling constant. This result supports the conjecture proposed by Guttmann and Enting concerning the ``solvability'' in statistical mechanical lattice models.Comment: 15 pages, 3 figures, RevTe

Targeting RyR Activity Boosts Antisense Exon 44 and 45 Skipping in Human DMD Skeletal or Cardiac Muscle Culture Models.

Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models. In humans with Duchenne muscular dystrophy treated with AOs, low levels of dystrophin have been induced, and modest slowing of disease progression has been observed, highlighting the need for improved efficiency of human skipping drugs. Here, we demonstrate that dantrolene and Rycals S107 and ARM210 potentiate AO-mediated exon skipping of exon 44 or exon 45 in patient-derived myotube cultures with appropriate mutations. Further, dantrolene is shown to boost AO-mediated exon skipping in patient-derived, induced cardiomyocyte cultures. Our findings further validate the ryanodine receptors (RyR) as the likely target responsible for exon skip boosting and demonstrate potential applicability beyond exon 51 skipping. These data provide preclinical support of dantrolene trial as an adjuvant to AO-mediated exon-skipping therapy in humans and identify a novel Rycal, ARM210, for development as a potential exon-skipping booster. Further, they highlight the value of mutation-specific DMD culture models for basic discovery, preclinical drug screening and translation of personalized genetic medicines