Size-Dependent Tile Self-Assembly: Constant-Height Rectangles and Stability

We introduce a new model of algorithmic tile self-assembly called size-dependent assembly. In previous models, supertiles are stable when the total strength of the bonds between any two halves exceeds some constant temperature. In this model, this constant temperature requirement is replaced by an nondecreasing temperature function $\tau : \mathbb{N} \rightarrow \mathbb{N}$ that depends on the size of the smaller of the two halves. This generalization allows supertiles to become unstable and break apart, and captures the increased forces that large structures may place on the bonds holding them together. We demonstrate the power of this model in two ways. First, we give fixed tile sets that assemble constant-height rectangles and squares of arbitrary input size given an appropriate temperature function. Second, we prove that deciding whether a supertile is stable is coNP-complete. Both results contrast with known results for fixed temperature.Comment: In proceedings of ISAAC 201

MTSS1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients

Large-Area Scintillator Hodoscope with 50 ps Timing Resolution Onboard BESS

We describe the design and performance of a large-area scintillator hodoscope onboard the BESS rigidity spectrometer; an instrument with an acceptance of 0.3 m^{2}sr. The hodoscope is configured such that 10 and 12 counters are respectively situated in upper and lower layers. Each counter is viewed from its ends by 2.5 inch fine-mesh photomultiplier tubes placed in a stray magnetic field of 0.2 Tesla. Various beam-test data are presented. Use of cosmic-ray muons at ground-level confirmed 50 ps timing resolution for each layer, giving an overall time-of-flight resolution of 70 ps rms using a pure Gaussian resolution function. Comparison with previous measurements on a similar scintillator hodoscope indicates good agreement with the scaling law that timing resolution is proportional to 1/$\sqrt{N_{\rm pe}}$, where $N_{\rm pe}$ is the effective number of photoelectrons.Comment: 16 pages, 14 figure

Superconformal constraints for QCD conformal anomalies

Anomalous superconformal Ward identities and commutator algebra in N = 1 super-Yang-Mills theory give rise to constraints between the QCD special conformal anomalies of conformal composite operators. We evaluate the superconformal anomalies that appear in the product of renormalized conformal operators and the trace anomaly in the supersymmetric spinor current and check the constraints at one-loop order. In this way we prove the universality of QCD conformal anomalies, which define the non-diagonal part of the anomalous dimension matrix responsible for scaling violations of exclusive QCD amplitudes at the next-to-leading order.Comment: 30 pages, 2 figures, LaTe

Pion and Kaon Production in e+e−e^+e^- and epep Collisions at Next-to-Leading Order

We present new sets of fragmentation functions for charged pions and kaons, both at leading and next-to-leading order. They are fitted to data on inclusive charged-hadron production in $e^+e^-$ annihilation taken by TPC at PEP ($\sqrt s=29$~GeV) and to similar data by ALEPH at LEP, who discriminated between events with charm, bottom, and light- flavour fragmentation in their charged-hadron sample. We treat all partons independently and to properly incorporate the charm and bottom thresholds. Due to the sizeable energy gap between PEP and LEP, we are sensitive to the scaling violation in the fragmentation process, which allows us to extract a value for the asymptotic scale parameter of QCD, $\Lambda$. Recent data on inclusive charged-hadron production in tagged three-jet events by OPAL and similar data for longitudinal electron polarization by ALEPH allow us to pin down the gluon fragmentation functions. Our new fragmentation functions lead to an excellent description of a multitude of other $e^+e^-$ data on inclusive charged-hadron production, ranging from $\sqrt s=5.2$~GeV to LEP energy. In addition, they agree nicely with the transverse-momentum spectra of single charged hadrons measured by H1 and ZEUS in photoproduction at the $ep$ collider HERA, which represents a nontrivial check of the factorization theorem of the QCD-improved parton model.Comment: 22 pages, latex, 13 compressed ps figures in separate fil

An SU(3) model for octet baryon and meson fragmentation

The production of the octet of baryons and mesons in e^+ e^- collisions is analysed, based on considerations of SU(3) symmetry and a simple model for SU(3) symmetry breaking in fragmentation functions. All fragmentation functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member of the baryon octet (and similarly for fragmentation into members of the meson octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x, Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3) breaking parameter, \lambda, the model is successful in describing hadroproduction data at the Z pole. The fragmentation functions are then evolved using leading order evolution equations and good fits to currently available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file

Critical Exponents and Particle Multiplicity Distributions in High Energy Collisions

Data from the L3, Tasso, Opal and Delphi collaborations are analyzed in terms of a statistical model of high energy collisions. The model contains a power law critical exponent tau and Levy index alpha. These data are used to study values of tau and alpha. The very high multiplicity events in L3, Opal and Delphi are consistent with a model based on a Feynman-Wilson gas which has a tail exponent tau=3/2 and alpha=1/2.Comment: 10 pages, new table adde

A Measurement of the D∗±D^{*\pm} Cross Section in Two-Photon Processes

We have measured the inclusive $D^{*\pm}$ production cross section in a two-photon collision at the TRISTAN $e^+e^-$ collider. The mean $\sqrt{s}$ of the collider was 57.16 GeV and the integrated luminosity was 150 $pb^{-1}$. The differential cross section ($d\sigma(D^{*\pm})/dP_T$) was obtained in the $P_T$ range between 1.6 and 6.6 GeV and compared with theoretical predictions, such as those involving direct and resolved photon processes.Comment: 8 pages, Latex format (article), figures corrected, published in Phys. Rev. D 50 (1994) 187

Measurement of the forward-backward asymmetries for charm- and bottom-quark pair productions at <s><\sqrt{s}>=58GeV with electron tagging

We have measured, with electron tagging, the forward-backward asymmetries of charm- and bottom-quark pair productions at $$=58.01GeV, based on 23,783 hadronic events selected from a data sample of 197pb$^{-1}$ taken with the TOPAZ detector at TRISTAN. The measured forward-backward asymmetries are $A_{FB}^c = -0.49 \pm 0.20(stat.) \pm 0.08 (sys.)$ and $A_{FB}^b = -0.64 \pm 0.35(stat.) \pm 0.13 (sys.)$, which are consistent with the standard model predictions.Comment: 19 pages, Latex format (article), 5 figures included. to be published in Phys. Lett.