647 research outputs found
On Charge-3 Cyclic Monopoles
We determine the spectral curve of charge 3 BPS su(2) monopoles with C_3
cyclic symmetry. The symmetry means that the genus 4 spectral curve covers a
(Toda) spectral curve of genus 2. A well adapted homology basis is presented
enabling the theta functions and monopole data of the genus 4 curve to be given
in terms of genus 2 data. The Richelot correspondence, a generalization of the
arithmetic mean, is used to solve for this genus 2 curve. Results of other
approaches are compared.Comment: 34 pages, 16 figures. Revision: Abstract added and a few small
change
Stability conditions and positivity of invariants of fibrations
We study three methods that prove the positivity of a natural numerical
invariant associated to parameter families of polarized varieties. All
these methods involve different stability conditions. In dimension 2 we prove
that there is a natural connection between them, related to a yet another
stability condition, the linear stability. Finally we make some speculations
and prove new results in higher dimension.Comment: Final version, to appear in the Springer volume dedicated to Klaus
Hulek on the occasion of his 60-th birthda
SU(2) WZW Theory at Higher Genera
We compute, by free field techniques, the scalar product of the SU(2)
Chern-Simons states on genus > 1 surfaces. The result is a finite-dimensional
integral over positions of ``screening charges'' and one complex modular
parameter. It uses an effective description of the CS states closely related to
the one worked out by Bertram. The scalar product formula allows to express the
higher genus partition functions of the WZW conformal field theory by
finite-dimensional integrals. It should provide the hermitian metric preserved
by the Knizhnik-Zamolodchikov-Bernard connection describing the variations of
the CS states under the change of the complex structure of the surface.Comment: 44 pages, IHES/P/94/10, Latex fil
2018 MAX-C/ExoMars Mission: The Orleans Mars-Analogue Rock Collection for Instrument Testing
International audienceIn order to reply to the exobiological goals of the 2018 MAX-C/ExoMars mission, the Orléans-OSUC analogue rock collection and database contains well characterised Mars analogue rocks and minerals for use in instrument testing and in situ missions
Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is unclear. To elucidate the role of JNK in MM, we evaluated the specific functions of the two major JNK proteins, JNK1 and JNK2. We show here that JNK2 is constitutively activated in a panel of MM cell lines and primary tumors. Using loss-of-function studies, we demonstrate that JNK2 is required for the survival of myeloma cells and constitutively suppresses JNK1-mediated apoptosis by affecting expression of poly(ADP-ribose) polymerase (PARP)14, a key regulator of B-cell survival. Strikingly, we found that PARP14 is highly expressed in myeloma plasma cells and associated with disease progression and poor survival. Overexpression of PARP14 completely rescued myeloma cells from apoptosis induced by JNK2 knockdown, indicating that PARP14 is critically involved in JNK2-dependent survival. Mechanistically, PARP14 was found to promote the survival of myeloma cells by binding and inhibiting JNK1. Moreover, inhibition of PARP14 enhances the sensitization of MM cells to anti-myeloma agents. Our findings reveal a novel regulatory pathway in myeloma cells through which JNK2 signals cell survival via PARP14, and identify PARP14 as a potential therapeutic target in myeloma.Kay Kendall Leukemia Fund, NIH, Cancer Research UK, Italian Association for Cancer Research and the Foundation for Liver Research
KMS states and conformal measures
From a non-constant holomorphic map on a connected Riemann surface we
construct an 'etale second countable locally compact Hausdorff groupoid whose
associated groupoid C*-algebra admits a one-parameter group of automorphisms
with the property that its KMS states corresponds to conformal measures in the
sense of Sullivan. In this way certain quadratic polynomials give rise to
quantum statistical models with a phase transition arising from spontaneous
symmetry breaking.Comment: The last section revised. This version will appear in Comm. Math.
Phy
The Bloom Clock for Causality Testing
Testing for causality between events in distributed executions is a
fundamental problem. Vector clocks solve this problem but do not scale well.
The probabilistic Bloom clock can determine causality between events with lower
space, time, and message-space overhead than vector clock; however, predictions
suffer from false positives. We give the protocol for the Bloom clock based on
Counting Bloom filters and study its properties including the probabilities of
a positive outcome and a false positive. We show the results of extensive
experiments to determine how these above probabilities vary as a function of
the Bloom timestamps of the two events being tested, and to determine the
accuracy, precision, and false positive rate of a slice of the execution
containing events in the temporal proximity of each other. Based on these
experiments, we make recommendations for the setting of the Bloom clock
parameters. We postulate the causality spread hypothesis from the application's
perspective to indicate whether Bloom clocks will be suitable for correct
predictions with high confidence. The Bloom clock design can serve as a viable
space-, time-, and message-space-efficient alternative to vector clocks if
false positives can be tolerated by an application
Computation of the Transient in Max-Plus Linear Systems via SMT-Solving
This paper proposes a new approach, grounded in Satisfiability Modulo
Theories (SMT), to study the transient of a Max-Plus Linear (MPL) system, that
is the number of steps leading to its periodic regime. Differently from
state-of-the-art techniques, our approach allows the analysis of periodic
behaviors for subsets of initial states, as well as the characterization of
sets of initial states exhibiting the same specific periodic behavior and
transient. Our experiments show that the proposed technique dramatically
outperforms state-of-the-art methods based on max-plus algebra computations for
systems of large dimensions.Comment: The paper consists of 22 pages (including references and Appendix).
It is accepted in FORMATS 2020 First revisio
Majorations explicites de fonctions de Hilbert-Samuel géométrique et arithmétique
International audienceBy using the -filtration approach of Arakelov geometry, one establishes explicit upper bounds for geometric and arithmetic Hilbert-Samuel function for line bundles on projective varieties and hermitian line bundles on arithmetic projective varieties
Conformal field theory approach to gapless 1D fermion systems and application to the edge excitations of nu = 1/(2p+1) quantum Hall sequences
We present a comprehensive study of the effective Conformal Field Theory
(CFT) describing the low energy excitations of a gas of spinless interacting
fermions on a circle in the gapless regime (Luttinger liquid). Functional
techniques and modular transformation properties are used to compute all
correlation functions in a finite size and at finite temperature. Forward
scattering disorder is treated exactly. Laughlin experiments on charge
transport in a Quantum Hall Fluid on a cylinder are reviewed within this CFT
framework. Edge excitations above a given bulk excitation are described by a
twisted version of the Luttinger effective theory. Luttinger CFTs corresponding
to the nu =1/(2p+1) filling fractions appear to be rational CFTs (RCFT).
Generators of the extended symmetry algebra are identified as edge fermions
creators and annihilators, thus giving a physical meaning to the RCFT point of
view on edge excitations of these sequences.Comment: 69 pages, 1 figure, LaTeX2e + amstex and graphicx packages needed,
fullpage.sty used (not compulsory
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