Preparation of films of a highly aligned lipid cubic phase

We demonstrate a method by which we can produce an oriented film of an inverse bicontinuous cubic phase (QII D) formed by the lipid monoolein (MO). By starting with the lipid as a disordered precursor (the L3 phase) in the presence of butanediol, we can obtain a film of the QII D phase showing a high degree of in-plane orientation by controlled dilution of the sample under shear within a linear flow cell. We demonstrate that the direction of orientation of the film is different from that found in the oriented bulk material that we have reported previously; therefore, we can now reproducibly form QII D samples oriented with either the [110] or the [100] axis aligned in the flow direction depending on the method of preparation. The deposition of MO as a film, via a moving fluid− air interface that leaves a coating of MO in the L3 phase on the capillary wall, leads to a sample in the [110] orientation. This contrasts with the bulk material that we have previously demonstrated to be oriented in the [100] direction, arising from flow producing an oriented bulk slug of material within the capillary tube. The bulk sample contains significant amounts of residual butanediol, which can be estimated from the lattice parameter of the QII D phase obtained. The sample orientation and lattice parameters are determined from synchrotron small-angle X-ray scattering patterns and confirmed by simulations. This has potential applications in the production of template materials and the growth of protein crystals for crystallography as well as deepening our understanding of the mechanisms underlying the behavior of lyotropic liquid-crystal phases

Theoretical analysis of perching and hovering maneuvers

Unsteady aerodynamic phenomena are encountered in a large number of modern aerospace and non-aerospace applications. Leading edge vortices (LEVs) are of particular interest because of their large impact on the forces and performance. In rotorcraft applications, they cause large vibrations and torsional loads (dynamic stall), affecting the performance adversely. In insect flight however, they contribute positively by enabling high-lift flight. Identifying the conditions that result in LEV formation and modeling their effects on the flow is an important ongoing challenge. Perching (airfoil decelerates to rest) and hovering (zero freestream velocity) maneuvers are of special interest. In earlier work by the authors, a Leading Edge Suction Parameter (LESP) was developed to predict LEV formation for airfoils undergoing arbitrary variation in pitch and plunge at a constant freestream velocity. In this research, the LESP criterion is extended to situations where the freestream velocity is varying or zero. A point-vortex model based on this criterion is developed and results from the model are compared against those from a computational fluid dynamics (CFD) method. Abstractions of perching and hovering maneuvers are used to validate the low-order model's performance in highly unsteady vortex-dominated flows, where the time-varying freestream/translational velocity is small in magnitude compared to the other contributions to the velocity experienced by the leading edge region of the airfoil. Time instants of LEV formation, flow topologies and force coefficient histories for the various motion kinematics from the low-order model and CFD are obtained and compared. The LESP criterion is seen to be successful in predicting the start of LEV formation and the point-vortex method is effective in modeling the flow development and forces on the airfoil. Typical run-times for the low-order method are between 30-40 seconds, making it a potentially convenient tool for control/design applications

tert-Butyl 3-[2,2-bis­(ethoxy­carbon­yl)­vinyl]-2-methyl-1H-indole-1-carboxyl­ate

In the title compound, C22H27NO6, the indole ring system is planar and the ethoxy­carbonyl chains adopt extended conformations. In the crystal, inversion dimers linked by pairs of C—H⋯O hydrogen bonds occur, resulting in R 2 2(16) dimers, which are inter­linked into a chain propagating along the a axis by π–π stacking inter­actions [centroid–centroid distance 3.5916 (9) Å]

4-(2,4-Dichlorophenyl)-2-(1H-indol-3-yl)-6-(2-pyridyl)-1,4-dihydropyridine-4-carbonitrile

The title compound, C25H16Cl2N4, has intra­molecular N—H⋯N and C—H⋯Cl hydrogen bonds. In the crystal structure, mol­ecules are linked through N—H⋯N hydrogen bonds, forming a centrosymmetric R 2 2(16) dimer

Diethyl 2-[(5-meth­oxy-2-methyl-1-phenyl­sulfonyl-1H-indol-3-yl)methyl­ene]malonate

In the title compound, C24H25NO7S, the sulfonyl-bound phenyl ring is approximately perpendicular to the indole ring system [dihedral angle = 87.72 (5)°]. The methyl group of one of the ester units is disordered over two positions with occupancies of 0.527 (13) and 0.473 (13). An intra­molecular C—H⋯O hydrogen bond is observed. In the crystal structure, mol­ecules are linked into a ribbon structure running along the c axis by inter­molecular C—H⋯O hydrogen bonds and C—H⋯π inter­actions involving the pyrrole ring

Analysis of model rotor blade pressures during parallel interaction with twin vortices

This paper presents and provides analysis of unsteady surface pressures measured on a model rotor blade as the blade experienced near parallel blade vortex interaction with a twin vortex system. To provide a basis for analysis, the vortex system was characterized by hot-wire measurements made in the interaction plane but in the absence of the rotor. The unsteady pressure response resulting from a single vortex interaction is then presented to provide a frame of reference for the twin vortex results. A series of twin vortex interaction cases are then presented and analyzed. It is shown that the unsteady blade pressures and forces are very sensitive to the inclination angle and separation distance of the vortex pair. When the vortex cores lie almost parallel to the blade chord, the interaction is characterized by a two-stage response associated with the sequential passage of the two cores. Conversely, when the cores lie on a plane that is almost perpendicular to the blade chord, the response is similar to that of a single vortex interaction. In all cases, the normal force response is consistent with the distribution of vertical velocity in the flow field of the vortex system. The pitching moment response, on the other hand, depends on the localized suction associated with the vortex cores as they traverse the blade chord

Cancer-selective, single agent chemoradiosensitising gold nanoparticles

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics

Academic Arrhythmia: Disruption, Dissonance and Conflict in the Early-Career Rhythms of CMS Academics

Starting a career on the margins of the neoliberal business school is becoming increasingly challenging. We contribute to the understanding of the problems involved and to potential solutions by developing a theoretically-informed approach to the rhythms of academic life and drawing on interviews with 32 Critical Management Studies (CMS) early-career academics (ECAs) in 14 countries. Bringing together Lefebvre’s rhythmanalysis (and his concepts of polyrhythmia, eurhythmia and arrhythmia), Zerubavel’s sociology of time, and identity construction literature, we examine the rhythm-identity implications of the recent HE changes. We show how the dynamics between the broader pressures, institutional strategies, and our interviewees’ attempts to reassert themselves are creating a vicious circle of arrhythmia – a debilitating condition characterized by rhythmic disruption, dissonance and conflict. Within the circle, identity insecurity and regulation, CMS ECAs’ identity work, and arrhythmia are mutually co-constructive, so that it is hard for individuals to break out. We consider the possibilities and limitations of individual coping strategies and, drawing out lessons for business schools, advocate for more collective and structural solutions. In so doing, we contribute to the reimagining of business schools as more eurhythmically polyrhythmic places where ECAs of all intellectual orientations have the time to learn and develop

Structural studies of thermally stable, combustion-resistant polymer composites

Composites of the industrially important polymer, poly(methyl methacrylate) (PMMA), were prepared by free-radical polymerization of MMA with varying amounts (1–30 wt. %) of sodium dioctylsulfosuccinate (Aerosol OT or AOT) surfactant added to the reaction mixture. The composites with AOT incorporated show enhanced resistance to thermal degradation compared to pure PMMA homopolymer, and micro-cone combustion calorimetry measurements also show that the composites are combustion-resistant. The physical properties of the polymers, particularly at low concentrations of surfactant, are not significantly modified by the incorporation of AOT, whereas the degradation is modified considerably for even the smallest concentration of AOT (1 wt. %). Structural analyses over very different lengthscales were performed. X-ray scattering was used to determine nm-scale structure, and scanning electron microscopy was used to determine μm-scale structure. Two self-assembled species were observed: large phase-separated regions of AOT using electron microscopy and regions of hexagonally packed rods of AOT using X-ray scattering. Therefore, the combustion resistance is observed whenever AOT self-assembles. These results demonstrate a promising method of physically incorporating a small organic molecule to obtain a highly thermally stable and combustion-resistant material without significantly changing the properties of the polymer