Service life prediction of running steel wire ropes

Vrlo visoka čvrstoća omogućava žičanom užetu da prenese velike zatezne sile i da se kreće po koturima relativno malog prečnika. Žice od čelika vrlo visoke čvrstoće su postojale više od sto godina pre nego što su patentirane, kada je uveden specijalni postupak zagrevanja i usavršen postupak izvlačenja. Dalja poboljšanja posle toga su uvedena u relativno malim koracima. Žičana užad uvek imaju ograničen radni vek. Zbog toga ona moraju da se podvrgnu inspekciji i ispitaju u pravilnim intervalima da bi se zamenila znatno pre otkaza. Krajnji korisnik mašine sa čeličnim žičanim užetom u svakom slučaju želi da ima grubu ocenu radnog veka užeta već u ranoj fazi razvoja mašine. tako da bude u mogućnosti, ako zatreba, da poboljša sistem mašine. To je jedan od razloga zbog kojih su tokom niza godina izvedena obimna istraživanja kako bi se poboljšali postupci proračuna za predviđanje radnog veka žičanih užadi. Namena ovog rada je da ponudi pregled informacija o postupcima proračuna i da prikaže mogućnosti i ograničenja postupaka prognoziranja za predviđanja radnog veka čeličnih žičanih užadi u eksploataciji.Very high strength enables wire ropes to support large tensile forces and to run over sheaves with relative small diameters. Very high strength steel wires had already been in existence for more than a hundred years when patenting, a special heating process was introduced and the drawing process improved. Since then, further improvements have only occurred in relatively small steps. Wire ropes always have a limited service life. Therefore they must be inspected and examined at regular intervals so that they are replaced well before failure. End-users of machinery with steel wire ropes, however, would like to have a rough estimation of the service life of the ropes already in the early stages of conceiving their machines, so that they can, if necessary, improve the revving system. This is one of the reasons why for many years extensive research is carried out in order to improve calculations for predicting the service life of wire ropes. This paper is meant to offer an overview information on the method of calculation and to demonstrate the potential and limitations of the forecasting procedure for service-life prediction of running steel wire ropes

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19(1,2), host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases(3-7). They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.Radiolog

Individual variations in cardiovascular-disease-related protein levels are driven by genetics and gut microbiome

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Building nextgeneration competencies for logisticians and supply chain managers

The resources developed in the project cover: Teaching/training materials in the three following areas: AREA 1: Sustainability as a service in supply chains & the manager of the future, that focuses on process and supply chain mapping toward emission minimisation, as well as improvements identification and implementation; AREA 2: New technologies in logistics, which covers: blockchain in logistics and Industry 4.0-related solutions; AREA 3: Intelligent logistics and transportation systems, that is about: systems design, stakeholders, risk management, resilience, as well as environmental and social regulations. Examples of good business practices related to the three above-mentioned areas. Case studies on implementing more sustainable operations (that were accounted with the LCA approach) with the identification of areas for improvement and proposals for improvement scenarios. All teaching/training materials are available in English, however, they are also translated into the languages of the participating countries: Polish, Greek and Slovenian. The learning material is accompanied by the Virtual Learning Environment that allows for online and open access to all developed materials. Additionally, we also offer you access to resources in SCORM standard, which allows to upload them to any compatible e-learning platform (e.g. Moodle) and use in any intended way for educational purposes at organisations beyond the project partnership. Finally, you will gain an opportunity for self-study and personal development (our materials are dedicated to students, postgraduates, managers and business professionals looking for competence development opportunities) or inspiration to teach/train others (our materials are also dedicated to teachers, trainers and educators in the field of logistics and supply chain management).In recent years the logistics market experienced rapid development and has been subject to substantive pressures and changes. Digital transformation of supply chains, rising complexity of transportation routes, uncertainties in collection and delivery times, growing interest in Industry 4.0, etc., emerged into intelligent (smart) supply chains. Furthermore, due to resource scarcity, the companies are looking for "green" solutions to integrate with their supply chains. With these observed changes, the global supply chains are currently progressing towards digital, intelligent and sustainable logistics (DISL). DISL is necessary to increase safety, tackle growing emissions and congestion problems, make processes within supply chains more efficient and sustainable, and enable the proper integration of today's society in the next-generation Industry 4.0 context. For this reason, we proposed the NEXTLOG project, which stands for "Building nextgeneration competencies for logisticians and supply chain managers". In this book, you will find who we are and what is the aim of the NEXTLOG Project. The consortium of the project comprises academic partners from 3 European countries and business partners that co-created the results and provided insight into the requirements of the market and external environment. Through the publication, you will get access to research results on the competencies that, according to the research conducted in Poland, Greece and Slovenia, are key for next-generation logisticians and supply chain managers.Erasmus+; KA2 - Cooperation for innovation and the exchange of good practices; KA203 - Strategic Partnerships for higher education; Decision No 2019-1-PL01-KA203-06573