A Fizikai Intézet Ra-Be neutronforrásának felhasználása és eltemetése

A 44 éven át oktatási célra használt laboratóriumi rádium-226-berillium neutronforrás felhasználási ideje lejárt, eltemetése szükségessé vált. A forrás szétszerelése, temetésre előkészítése egyedülálló, szakmailag komoly feladatot jelentett. A cikkben beszámolunk a feladat előírások szerinti végrehajtásáról. A mérési eredmények alapján a radioaktív hulladéktemetőnek egy sértetlen, teljesen zárt izotópot adtunk át

New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe

Background: Chronic mucocutaneous candidiasis disease (CMCD) may result from various inborn errors of interleukin (IL)-17-mediated immunity. Twelve of the 13 causal mutations described to date affect the coiled-coil domain (CCD) of STAT1. Several mutations, including R274W in particular, are recurrent, but the underlying mechanism is unclear. Objective: To investigate and describe nine patients with CMCD in Eastern and Central Europe, to assess the biochemical impact of STAT1 mutations, to determine cytokines in supernatants of Candida-exposed blood cells, to determine IL-17-producing T cell subsets and to determine STAT1 haplotypes in a family with the c.820C>T (R274W) mutation. Results: The novel c.537C>A (N179K) STAT1 mutation was gain-of-function (GOF) for γ-activated factor (GAF)-dependent cellular responses. In a Russian patient, the cause of CMCD was the newly identified c.854 A>G (Q285R) STAT1 mutation, which was also GOF for GAF-dependent responses. The c.1154C>T (T385M) mutation affecting the DNA-binding domain (DBD) resulted in a gain of STAT1 phosphorylation in a Ukrainian patient. Impaired Candida-induced IL-17A and IL-22 secretion by leucocytes and lower levels of intracellular IL-17 and IL-22 production by T cells were found in several patients. Haplotype studies indicated that the c.820C>T (R274W) mutation was recurrent due to a hotspot rather than a founder effect. Severe clinical phenotypes, including intracranial aneurysm, are presented. Conclusions: The c.537C>A and c.854A>G mutations affecting the CCD and the c.1154C>T mutation affecting the DBD of STAT1 are GOF. The c.820C>T mutation of STAT1 in patients with CMCD is recurrent due to a hotspot. Patients carrying GOF mutations of STAT1 may develop multiple intracranial aneurysms by hitherto unknown mechanisms

Lantán-bentonit előállítása

Munkám során Istenmezei Ca-bentonitból lantán-bentonitot állítottam elő különböző hőmérsékleten, majd megvizsgáltam, hogy a hőmérséklet hogyan befolyásolja a kationcsere mértékét.BSc/BAvegyészmérnökg