The C-11-radioisotopic study of methanol conversion on V-MCM-41: The influence of methyl iodide on the transformation

The methanol conversion and a feasible methanol co-reaction with methyl iodide were studied on a vanadium incorporated MCM-41 type (V-MCM-41) mesoporous catalyst. which was prepared by a direct hydrothermal synthesis method. Adsorption/desorption as well as conversion derivates of radioactive methanol were easily followed by radioactivity detectors on V-MCM-41. The transformation and coreaction products were analyzed by a gas chromatograph equipped with Radio/FID detectors. The radiodetector was applied to distinguish C-11-derivates from the non-radioactive methyl iodide and its derivates. The radio-labeling method proved methanol transformation to methylal and, in the presence of methyl iodide, decided the roles of methyl group and iodide of methyl iodide in newly synthesized methyl iodide formation in the absence of oxygen gas

Cross sections of proton-induced reactions on natGd with special emphasis on the production possibilities of 152Tb and 155Tb

Cross sections and physical yields are presented for various Tb radionuclides formed in the bombardment of natGd with protons, from their respective thresholds up to 66 MeV. New measurements are compared with theoretical predictions by means of the geometry-dependent hybrid (GDH) model as implemented in the code ALICE/ASH, as well as with previous literature experimental data, where available.Based on the agreement between the experimental results and the theoretical predictions, integral thick-target yields are also derived for the 152Gd(p,n) 152Tb, 155Gd(p,n) 155Tb and 155Gd(p,4n) 152Tb reactions forming the medically important 152gTb (SPECT) and 155Tb (PET) radionuclides

Simulation study of the proton-induced reaction cross sections for the production of F-18 and Ga66-68 radioisotopes

WOS: 000416545300094The excitation functions of O-18(p,n) and Zn66-68(p,xn) reactions were calculated using nuclear model based computer codes for the production of F-18 and Ga66-68 radioisotopes. The model-based calculations, EMPIRE 3.2 Malta, ALICE/ASH and TALYS 1.8 nuclear reaction codes were used for obtaining the cross sections in the production of these radioisotopes. The nuclear reaction model results were compared to the existing experimental values, and TENDL-2015 data. It is generally accepted that the cross section predictions obtained using Superfluid model are preferable for the better description of experimental measurements

Unconventional Nuclides for Radiopharmaceuticals

Rapid and widespread growth in the use of nuclear medicine for both diagnosis and therapy of disease has been the driving force behind burgeoning research interests in the design of novel radiopharmaceuticals. Until recently, the majority of clinical and basic science research has focused on the development of 11 C-, 13 N-, 15 O-, and 18 F-radiopharmaceuticals for use with positron emission tomography (PET) and 99m Tc-labeled agents for use with single-photon emission computed tomography (SPECT). With the increased availability of small, low-energy cyclotrons and improvements in both cyclotron targetry and purification chemistries, the use of “nonstandard” radionuclides is becoming more prevalent. This brief review describes the physical characteristics of 60 radionuclides, including β + , β −− , γ-ray, and α-particle emitters, which have the potential for use in the design and synthesis of the next generation of diagnostic and/or radiotherapeutic drugs. As the decay processes of many of the radionuclides described herein involve emission of high-energy γ-rays, relevant shielding and radiation safety issues are also considered. In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64 Cu, 68 Ga, 86 Y, 89 Zr, and 124 I are discussed