Újkőkori településrészlet Novajidrány határában : előzetes jelentés Novajidrány, Szőlő-alja II. lelőhely feltárásáról

A Magyar Nemzeti Múzeum Régészeti Örökségvédelmi Igazgatósága az M30-as számú gyorsforgalmi út Miskolcot Košice/Kassával összekötő szakaszának építési munkálatai során 2018. augusztus 28. és szeptember 19. között egy újkőkori település részleges feltárását végezte el Novajidrány, Szőlő-alja II. lelőhelyen. Az előzetes feldolgozás alapján az előkerült mintegy 86, településhez, illetve temetkezéshez köthető objektum az Alföldi Vonaldíszes Kerámia kultúrája (AVK) legkorábbi, kialakuló fázisára keltezhető

The Istállóskő Cave Excavation in 2020 and Its Research Objectives

Istállós-kői-barlang (Istállóskő Cave) is one of the most famous prehistoric sites in the Bükk Mountains of Northeast Hungary. This cave is the most visited archaeological site for tourists in Hungary, due to its location in the valley of Szalajka Stream, a high-tourism area of the Bükk Nature Reserve. The site can be visited freely but is protected by nature conservation laws. The importance of Istállóskő Cave is based on the fact that it is one of the oldest shelters used by the first anatomically modern humans in Europe. Field research that obtained a variety of samples for interdisciplinary studies was carried out decades ago, but the methods for investigating Palaeolithic sites have become more refined since that time. This inspired us to conduct a renewed excavation at the site to understand the ecological aspects of the first anatomically modern humans in Central Europe bette

Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke

<p>Abstract</p> <p>Background</p> <p>A number of data indicate that the lectin pathway of complement activation contributes to the pathophysiology of ischemic stroke. The lectin pathway may be triggered by the binding of mannose-binding lectin (MBL), ficolin-2 or ficolin-3 to different ligands. Although several papers demonstrated the significance of MBL in ischemic stroke, the role of ficolins has not been examined.</p> <p>Methods</p> <p>Sera were obtained within 12 hours after the onset of ischemic stroke (admission samples) and 3-4 days later (follow-up samples) from 65 patients. The control group comprised 100 healthy individuals and 135 patients with significant carotid stenosis (patient controls). The concentrations of ficolin-2 and ficolin-3, initiator molecules of the lectin complement pathway, were measured by ELISA methods. Concentration of C-reactive protein (CRP) was also determined by a particle-enhanced immunturbidimetric assay.</p> <p>Results</p> <p>Concentrations of both ficolin-2 and ficolin-3 were significantly (p < 0.001) decreased in both the admission and in the follow-up samples of patients with definite ischemic stroke as compared to healthy subjects. Concentrations of ficolin-2 and ficolin-3 were even higher in patient controls than in healthy subjects, indicating that the decreased levels in sera during the acute phase of stroke are related to the acute ischemic event. Ficolin-3 levels in the follow-up samples inversely correlated with the severity of stroke indicated by NIH scale on admission. In follow-up samples an inverse correlation was observed between ficolin-3 levels and concentration of S100β, an indicator of the size of cerebral infarct. Patients with low ficolin-3 levels and high CRP levels in the follow up samples had a significantly worse outcome (adjusted ORs 5.6 and 3.9, respectively) as measured by the modified Rankin scale compared to patients with higher ficolin-3 and lower CRP concentrations. High CRP concentrations were similarly predictive for worse outcome, and the effects of low ficolin-3 and high CRP were independent.</p> <p>Conclusions</p> <p>Our findings indicate that ficolin-mediated lectin pathways of complement activation contribute to the pathogenesis of ischemic stroke and may be additive to complement-independent inflammatory processes.</p

Chlorine Dioxide Is a Size-Selective Antimicrobial Agent

Background / Aims: ClO2, the so-called "ideal biocide", could also be applied as an antiseptic if it was understood why the solution killing microbes rapidly does not cause any harm to humans or to animals. Our aim was to find the source of that selectivity by studying its reaction-diffusion mechanism both theoretically and experimentally. Methods: ClO2 permeation measurements through protein membranes were performed and the time delay of ClO2 transport due to reaction and diffusion was determined. To calculate ClO2 penetration depths and estimate bacterial killing times, approximate solutions of the reaction-diffusion equation were derived. In these calculations evaporation rates of ClO2 were also measured and taken into account. Results: The rate law of the reaction-diffusion model predicts that the killing time is proportional to the square of the characteristic size (e. g. diameter) of a body, thus, small ones will be killed extremely fast. For example, the killing time for a bacterium is on the order of milliseconds in a 300 ppm ClO2 solution. Thus, a few minutes of contact time (limited by the volatility of ClO2) is quite enough to kill all bacteria, but short enough to keep ClO2 penetration into the living tissues of a greater organism safely below 0.1 mm, minimizing cytotoxic effects when applying it as an antiseptic. Additional properties of ClO2, advantageous for an antiseptic, are also discussed. Most importantly, that bacteria are not able to develop resistance against ClO2 as it reacts with biological thiols which play a vital role in all living organisms. Conclusion: Selectivity of ClO2 between humans and bacteria is based not on their different biochemistry, but on their different size. We hope initiating clinical applications of this promising local antiseptic