Traditions And Transformations:Five Years Of Civil War Books

Interview with Sylvia Frank Rodrigue by Christopher S. Freeman Sylvia Frank Rodrigue is former editor-in-chief of Louisiana State University Press, where over the course of eight years she acquired more than 180 books of history, political science, literary criticism, an...

Self-referential cognition and interests of girls and boys in mathematics lessons at primary school

Der Beitrag beschäftigt sich mit der Frage, inwiefern geschlechtsspezifische Unterschiede in der mathematischen Kompetenz bei Kindern bereits im Grundschulalter vorliegen und wie diese erklärt werden können. Vor diesem Hintergrund wird über eine Untersuchung berichtet, an der insgesamt n=470 Kinder des vierten Schuljahres beteiligt waren. Die Kinder wurden zu ihren mathematischen Kompetenzen sowie zu Indikatoren ihrer leistungsbezogenen Persönlichkeitsentwicklung befragt. Die Ergebnisse zeigen zwar keine Unterschiede in Hinblick auf die mathematischen Kompetenzen von Mädchen und Jungen, wohl aber Differenzen in Bezug auf ihre leistungsbezogenen Selbstkonzepte und ihr Mathematikinteresse. Es zeigt sich, dass die Jungen über höhere Selbstkonzepte und Interessen in Mathematik verfügen als die Mädchen. (DIPF/Orig.)The article deals with the question of how gender differences in mathematical literacy among children at elementary school are available and how these differences can be explained. There is reporting on a study in which a total of n=470 children were involved. The children were interviewed about their maths skills and some of their school-related personality factors. The results show no differences in terms of the mathematical skills of girls and boys at elementary school but differences in terms of their self-concepts and their interest in mathematics: The boys have higher self-concepts and interests in maths than girls. (DIPF/Orig.

Kosmischer Staub im Nano-Labor : ein Blick in die Kinderstube des Sonnensystems

Staubwolken sind im Universum die Geburtsstätten neuer Sterne. Dort wiederholen sich Prozesse, die vor 4,56 Milliarden Jahren auch zur Entstehung unseres Sonnensystems geführt haben. Noch heute gibt es Zeugen aus dieser Zeit: Kometenstaub, Sternenstaub und interstellarer Staub. Die »Stardust-Mission« hat sie eingefangen, und Frankfurter Geowissenschaftler haben darin – dank modernster Labor-Analytik – erstaunliche Funde gemacht

CC3/TIP30 affects DNA damage repair

<p>Abstract</p> <p>Background</p> <p>The pro-apoptotic protein CC3/TIP30 has an unusual cellular function as an inhibitor of nucleocytoplasmic transport. This function is likely to be activated under conditions of stress. A number of studies support the notion that CC3 acts as a tumor and metastasis suppressor in various types of cancer. The yeast homolog of CC3 is likely to be involved in responses to DNA damage. Here we examined the potential role of CC3 in regulation of cellular responses to genotoxic stress.</p> <p>Results</p> <p>We found that forced expression of CC3 in CC3-negative cells strongly delays the repair of UV-induced DNA damage. Exogenously introduced CC3 negatively affects expression levels of DDB2/XPE and p21CIP1, and inhibits induction of c-FOS after UV exposure. In addition, exogenous CC3 prevents the nuclear accumulation of P21CIP in response to UV. These changes in the levels/localization of relevant proteins resulting from the enforced expression of CC3 are likely to contribute to the observed delay in DNA damage repair. Silencing of CC3 in CC3-positive cells has a modest delaying effect on repair of the UV induced damage, but has a much more significant negative affect on the translesion DNA synthesis after UV exposure. This could be related to the higher expression levels and increased nuclear localization of p21CIP1 in cells where expression of CC3 is silenced. Expression of CC3 also inhibits repair of oxidative DNA damage and leads to a decrease in levels of nucleoredoxin, that could contribute to the reduced viability of CC3 expressing cells after oxidative insult.</p> <p>Conclusions</p> <p>Manipulation of the cellular levels of CC3 alters expression levels and/or subcellular localization of proteins that exhibit nucleocytoplasmic shuttling. This results in altered responses to genotoxic stress and adversely affects DNA damage repair by affecting the recruitment of adequate amounts of required proteins to proper cellular compartments. Excess of cellular CC3 has a significant negative effect on DNA repair after UV and oxidant exposure, while silencing of endogenous CC3 slightly delays repair of UV-induced damage.</p