Effect of percutaneous mitral vavuloplasty on pregnant mother and foetus--a tertiary care hospital experience from a developing country

This study evaluated the short and long-term consequences of Percutaneous Mitral Valvuloplasty (PMV) in pregnant patients and their offspring, in a tertiary care setting, Karachi, Pakistan. The hospital database was used to retrieve all patients who underwent PMV during pregnancy in the period 1998-2007. The follow up data of the patients and the born children were obtained from the hospital records and also by contacting the patients via phone. Six patients underwent PMV but follow-up was available for 5 patients only. All 5 patients were admitted due to severe mitral stenosis with symptoms of dyspnea and palpitation. Mean age was 27 +/- 5.3 years with a mean gestational age at the time of procedure of 22.20 +/- 1.6 weeks. The mean valve area increased from 0.94 +/- 0.22 cm2 preoperatively to 1.62 +/- 0.50 cm2 post-operatively. The ejection fraction changed from a mean of 50 +/- 11.7% to 56 +/- 2.2%. There were no maternal deaths, abortions or stillbirths. Developmental milestones were achieved at the appropriate ages in all babies. PMV appears to be a safe and effective intervention for patients with severe MS during pregnancy. Keywords: Mitral stenosis, Percutaneous Mitra

Possibilities of Regional Trade Expansion: A Link Model for Pakistan, India, Bangladesh and Sri Lanka

Econometric models are generally constructed for a specific country on the assumption that national economies are independent. In reality, this is not the case. In this paper, we have constructed prototype linkage econometric models for Pakistan, India, Bangladesh and Sri Lanka, These models are linked to each other through foreign-trade equations to explore possibilities of fruitful economic cooperation among these four countries Policy simulations, carried out to highlight the pay-off of specific policies in terms of the stated objective, show that, given the resolve of these countries to extend the area of collaboration, the prospects are by no means dim. There is also the extra bonus that the growth of GNP in the region will also be helped by mutual economic co-operation. The need for conscious policy decisions to this effect has been underscored

Enhancing properties of iron and manganese ores as oxygen carriers for chemical looping processes by dry impregnation

The use of naturally occurring ores as oxygen carriers in CLC processes is attractive because of their relative abundance and low cost. Unfortunately, they typically exhibit lower reactivity and lack the mechanical robustness required, when compared to synthetically produced carriers. Impregnation is a suitable method for enhancing both the reactivity and durability of natural ores when used as oxygen carriers for CLC systems. This investigation uses impregnation to improve the chemical and mechanical properties of a Brazilian manganese ore and a Canadian iron ore. The manganese ore was impregnated with Fe2O3 and the iron ore was impregnated with Mn2O3 with the goal of forming a combined Fe/Mn oxygen carrier. The impregnated ore’s physical characteristics were assessed by SEM, BET and XRD analysis. Measurements of the attrition resistance and crushing strength were used to investigate the mechanical robustness of the oxygen carriers. The impregnated ore’s mechanical and physical properties were clearly enhanced by the impregnation method, with boosts in crushing strength of 11–26% and attrition resistance of 37–31% for the impregnated iron and manganese ores, respectively. Both the unmodified and impregnated ore’s reactivity, for the conversion of gaseous fuel (CH4 and syngas) and gaseous oxygen release (CLOU potential) were investigated using a bench-scale quartz fluidised-bed reactor. The impregnated iron ore exhibited a greater degree of syngas conversion compared to the other samples examined. Iron ore based oxygen carrier’s syngas conversion increases with the number of oxidation and reduction cycles performed. The impregnated iron ore exhibited gaseous oxygen release over extended periods in an inert atmosphere and remained at a constant 0.2% O2 concentration by volume at the end of this inert period. This oxygen release would help ensure the efficient use of solid fuels. The impregnated iron ore’s reactivity for CH4 conversion was similar to the reactivity of its unmodified counterpart. The unmodified manganese ore converted CH4 to the greatest extent of all the samples tested here, while the impregnated manganese ore exhibited a decrease in reactivity with respect to syngas and CH4 conversion.EPSR

HIV/AIDS in Pakistan: the battle begins

Pakistan, the second most populous Muslim nation in the world, has started to finally experience and confront the HIV/AIDS epidemic. The country had been relatively safe from any indigenous HIV cases for around two decades, with most of the infections being attributable to deported HIV positive migrants from the Gulf States. However, the virus finally seems to have found a home-base, as evidenced by the recent HIV outbreaks among the injection drug user community. Extremely high-risk behavior has also been documented among Hijras (sex workers) and long-distance truck drivers. The weak government response coupled with the extremely distressing social demographics of this South-Asian republic also helps to compound the problem. The time is ripe now to prepare in advance, to take the appropriate measures to curtail further spread of the disease. If this opportunity is not utilized right now, little if at all could be done later

Compact Polarization Diversity Antenna for 28/38 GHz Bands

In this paper, design and analysis of a millimeter wave dual- and dual-polarized antenna for 5G millimeter communications system is presented. The proposed design has a compact structure with size of 5 × 5 mm 2 . It consists of a rectangular patch with a crossed-slot etched off in the patch to reduce the interference between the two targeted 5G bands of 28 and 38 GHz. To achieve dual polarization performance, the radiating patch is fed by two different 50-Ω microstrip transmission lines. The antenna has -10dB impedance bandwidths of 2.6GHz (26.8-29.4 GHz) and 2.5GHz (37.7-40.2GHz) to cover 28/38 GHz mobile communication bands respectively. The antenna has the merits of miniaturized dimensions, stable broadside radiation patterns with high gains and low cross polarization in both bands of operation

Integration of TTF, UTAUT, and ITM for mobile Banking Adoption

The introduction of mobile banking facility has enabled customers to carry out banking transactionswith the use of smartphones and other handheld devices from anywhere. It has become a luxurious and exclusive method of online payments. The recent growth of telecommunication sector and a tremendous increase in mobile USAge has opened new doors for sparking future of banking sector industry. The following research is aimed to find out the mobile banking adoption attitudes with the integration of TTF, UTAUT,and ITM models

An overview on recent biomedical applications of biopolymers: Their role in drug delivery systems and comparison of major systems

Polymers are ubiquitous in our daily lives, from workplaces to homes. Biopolymers are becoming more popular as an alternative to petroleum-based polymers because of their lower environmental impact due to their low carbon footprint and easy degradation. The primary aim of developing technology is a better quality of life. Improved therapies and tailor-made treatments are currently the focus of scientists. However, the delivery of drugs has been a long problem in the field of medicine. As a result, many drug delivery systems (DDSs) have been created for this purpose. Among these, nanotechnology-based DDSs, especially nanofibers, hold a promising future. This review focuses on the importance of naturally abundant biopolymers in recent medical applications, especially their role in DDSs, and provides a crucial comparison of the merits and demerits of the major DDSs for researchers to develop tailor-made DDSs

Therapeutic targeting of integrin αvβ6 in breast cancer

BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n &gt; 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of ?6 in breast cell lines, the role of ?v?6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, invasion, growth in vivo) was assessed by flow cytometry, MTT, Transwell invasion, proximity ligation assay, and xenografts (n ? 3), respectively. A student's t-test was used for two variables; three-plus variables used one-way analysis of variance with Bonferroni's Multiple Comparison Test. Xenograft growth was analyzed using linear mixed model analysis, followed by Wald testing and survival, analyzed using the Log-Rank test. All statistical tests were two sided.RESULTS: High expression of either the mRNA or protein for the integrin subunit ?6 was associated with very poor survival (HR = 1.60, 95% CI = 1.19 to 2.15, P = .002) and increased metastases to distant sites. Co-expression of ?6 and HER2 was associated with worse prognosis (HR = 1.97, 95% CI = 1.16 to 3.35, P = .01). Monotherapy with 264RAD or trastuzumab slowed growth of MCF-7/HER2-18 and BT-474 xenografts similarly (P &lt; .001), but combining 264RAD with trastuzumab effectively stopped tumor growth, even in trastuzumab-resistant MCF-7/HER2-18 xenografts.CONCLUSIONS: Targeting ?v?6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.<br/

Characterisation of the Stromal Microenvironment in Lobular Breast Cancer

SIMPLE SUMMARY: Invasive lobular breast cancer (ILC) accounts for approximately 5–15% of breast cancers, and although response rates to treatments are initially good, an ILC diagnosis is associated with adverse long-term outcomes; better treatments, specifically targeted to this sub-type of breast cancer, are required to improve patient survival. The tumor microenvironment (TME) plays an important role in determining how cancers respond to treatment, and in this study, we carried out an in-depth analysis of the TME in ILC following laser-capture microdissection of the tumor stroma, and analysis of primary cancer-associated fibroblasts (CAFs), which comprise the majority of non-malignant cells within tumors. This identified changes in genes involved in regulation of the extracellular matrix and also growth factor signaling pathways that were differentially regulated in ILC. Further analysis of breast cancer datasets showed that two of these genes which encode a secreted metalloproteinase (PAPPA) and a metalloproteinase inhibitor (TIMP2) were associated with survival outcomes in ILC. ABSTRACT: Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer, and it exhibits a number of clinico-pathological characteristics distinct from the more common invasive ductal carcinoma (IDC). We set out to identify alterations in the tumor microenvironment (TME) of ILC. We used laser-capture microdissection to separate tumor epithelium from stroma in 23 ER+ ILC primary tumors. Gene expression analysis identified 45 genes involved in regulation of the extracellular matrix (ECM) that were enriched in the non-immune stroma of ILC, but not in non-immune stroma from ER+ IDC or normal breast. Of these, 10 were expressed in cancer-associated fibroblasts (CAFs) and were increased in ILC compared to IDC in bulk gene expression datasets, with PAPPA and TIMP2 being associated with better survival in ILC but not IDC. PAPPA, a gene involved in IGF-1 signaling, was the most enriched in the stroma compared to the tumor epithelial compartment in ILC. Analysis of PAPPA- and IGF1-associated genes identified a paracrine signaling pathway, and active PAPP-A was shown to be secreted from primary CAFs. This is the first study to demonstrate molecular differences in the TME between ILC and IDC identifying differences in matrix organization and growth factor signaling pathways

Utilizing a 5G spectrum for health care to detect the tremors and breathing activity for multiple sclerosis

Utilizing fifth‐generation (5G) sensing in the health care sector with increased capacity and massive spectrum range increases the quality of health care monitoring systems. In this paper, 5G C‐band sensing operating at 4.8 GHz is used to monitor a particular body motion of multiple sclerosis patients, especially the tremors and breathing patterns. The breathing pattern obtained using 5G C‐band technology is compared with the invasive breathing sensor to monitor the subtle chest movements caused due to respiration. The 5G C‐band has a huge spectrum from 1 to 100 GHz, which enhances the capacity and performance of wireless communication by increasing the data rate from 20 Gb/s to 1 Tb/s. The system captures and monitors the wireless channel information of different body motions and efficiently identifies the tremors experienced since each body motion induces a unique imprint that is used for a particular purpose. Different machine learning algorithms such as support vector machine, k‐nearest neighbors, and random forest are used to classify the wireless channel information data obtained for various human activities. The values obtained using different machine learning algorithms for various performance metrics such as accuracy, precision, recall, specificity, Kappa, and F‐measure indicate that the proposed method can efficiently identify the particular conditions experienced by multiple sclerosis patients