Reducing numerical diffusion for incompressible flow calculations

A number of approaches for improving the accuracy of incompressible, steady-state flow calculations are examined. Two improved differencing schemes, Quadratic Upstream Interpolation for Convective Kinematics (QUICK) and Skew-Upwind Differencing (SUD), are applied to the convective terms in the Navier-Stokes equations and compared with results obtained using hybrid differencing. In a number of test calculations, it is illustrated that no single scheme exhibits superior performance for all flow situations. However, both SUD and QUICK are shown to be generally more accurate than hybrid differencing

Effect of vitamin A supplementation in category-I Pulmonary Tuberculosis patients in a Medical College in India: a rapid assessment analysis

Background: Tuberculosis is one of the major health problems affecting the global population causing immense morbidity and mortality. Studies have shown that a good antioxidant status of the body has immune protective role against tuberculosis and may be associated with a decreased risk of the disease and slower rate of progression. Objective of the study was planned to evaluate the beneficial effects of Vitamin A as add on therapy to the standard drug therapy in patients with sputum positive pulmonary tuberculosis.Methods: The study was done in a Tuberculosis clinic, Department of Internal Medicine, Stanley Medical College for duration of 6 months. All the newly diagnosed sputum positive pulmonary tuberculosis patients (18-55 years) attending the outpatient were taken for the study purpose. A Phase III, prospective, open, two arm parallel group, outpatient, randomized, active controlled study was done.Results: After two weeks of therapy, the number of patients with negative sputum smear was higher in the study group than the control group. Vitamin A supplementation resulted in an earlier elimination of tubercle bacilli from the sputum.Conclusions: This study shows that vitamin A as add on therapy to the existing standard therapy improves the clinical response and decreases the disease activity to a greater extent than with routine standard therapy alone

A comparative study of mebeverine and synbiotic combination in patients with diarrhoea predominant Irritable Bowel Syndrome in a Medical College in South India

Background: Irritable bowel syndrome (IBS) is a chronic, episodic functional gastrointestinal disorder characterized by abdominal pain / discomfort and altered bowel habits. Though it is considered as a functional disorder, the burden of the disease to the patients is very high and the quality of life becomes miserable. Currently available IBS therapies are mainly symptom oriented and have limited efficacy. Various studies had done so far which provide a clear rationale for the use of Synbiotic in this disorder. The objective of the study includes, this study was planned to compare the efficacy of Mebeverine + Synbiotic combination with Mebeverine and Synbiotic monotherapy in patients with diarrhoea predominant irritable bowel syndrome.Methods: The study was done in Department of Medical Gastroenterology, Rajiv Gandhi Government Hospital, Chennai for duration of one year. Patients with Irritable Bowel Syndrome (diarrhea predominant type), diagnosed within 1 year and attending outpatient department were taken. A randomized, Phase III, prospective, interventional, open label, outpatient, comparative study design was done. A total of 60 patients divided into 3 groups were finally selected for the study purpose.Results: Twelve weeks after completion of active drug therapy, the Mebeverine + Synbiotic combination improved all the symptoms of IBS except abdominal pain. Further it was evident that combination therapy had significant remission in stool frequency and consistency when compared with other groups.Conclusions: Combination of Mebeverine + Synbiotic is more effective in improving most of the troublesome symptoms in patients with diarrhea predominant irritable bowel syndrome than other therapies and also in maintaining remission, in terms of frequency and consistency of stools

Imaging benign inflammatory syndromes

AbstractBenign mastitis is a rare disease and its management is difficult. The diagnostic challenge is to distinguish it from carcinomatous mastitis. We make a distinction between acute mastitis secondary to an infection, to inflammation around a benign structure or to superficial thrombophlebitis, and chronic, principally plasma cell and idiopathic granulomatous mastitis. Imaging is often non-specific but we need to know and look for certain ultrasound, mammogram or magnetic resonance imaging (MRI) signs to give a pointer as early as possible towards a benign aetiology. A biopsy should be undertaken systematically where there is the slightest diagnostic doubt, to avoid failing to recognise a carcinomatous mastitis

Pool boiling on modified surfaces using R-123

This article has been made available through the Brunel Open Access Publishing Fund.Saturated pool boiling of R-123 was investigated for five horizontal copper surfaces modified by different treatments, namely, an emery-polished surface, a fine sandblasted surface, a rough sandblasted surface, an electron beam-enhanced surface, and a sintered surface. Each 40-mm-diameter heating surface formed the upper face of an oxygen-free copper block, electrically heated by embedded cartridge heaters. The experiments were performed from the natural convection regime through nucleate boiling up to the critical heat flux, with both increasing and decreasing heat flux, at 1.01 bar, and additionally at 2 bar and 4 bar for the emery-polished surface. Significant enhancement of heat transfer with increasing surface modification was demonstrated, particularly for the electron beam-enhanced and sintered surfaces. The emery-polished and sandblasted surface results are compared with nucleate boiling correlations and other published data. © 2014 Syed W. Ahmad, John S. Lewis, Ryan J. McGlen, and Tassos G. Karayiannis Published with license by Taylor & Francis

Passivity and Immersion based-modified gradient estimator: A control perspective in parameter estimation

In this paper, a constructive and systematic strategy with more apparent degrees of freedom to achieve the accurate estimation of unknown parameters via a control perspective is proposed. By adding a virtual control in the final equation of the gradient dynamics, the Gradient Estimator (GE) and Memory Regressor and Extension (MRE) approaches are extended. The solution of the virtual control law is identified by the P&I approach. The P&I approach is based on the choice of an appropriate implicit manifold and the generation of a suitable passive output and a related storage function. This facilitates the virtual control law being obtained in a way that the parametric error converges asymptotically to zero. Because the above ideas connect with the P&I approach and GE, the developed methodology is labeled the passivity and immersion-based modified gradient estimator (MGE). The proposed P&I-based modified gradient estimator is extended via the MRE approach. This modification provides improved transient response and fast convergence. Based on certain PE and non-PE examples, a comparative analysis is carried out to show the efficacy of the proposed approaches

Serious Bacterial Infections Acquired During Treatment of Patients Given a Diagnosis of Chronic Lyme Disease - United States.

The term "chronic Lyme disease" is used by some health care providers as a diagnosis for various constitutional, musculoskeletal, and neuropsychiatric symptoms (1,2). Patients with a diagnosis of chronic Lyme disease have been provided a wide range of medications as treatment, including long courses of intravenous (IV) antibiotics (3,4). Studies have not shown that such treatments lead to substantial long-term improvement for patients, and they can be harmful (1,5). This report describes cases of septic shock, osteomyelitis, Clostridium difficile colitis, and paraspinal abscess resulting from treatments for chronic Lyme disease. Patients, clinicians, and public health practitioners should be aware that treatments for chronic Lyme disease can carry serious risks

NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.

BackgroundThe molecular pathway that controls cardiogenesis is temporally and spatially regulated by master transcriptional regulators such as NKX2-5, Isl1, MEF2C, GATA4, and beta-catenin. The interplay between these factors and their downstream targets are not completely understood. Here, we studied regulation of beta-catenin and GATA4 by NKX2-5 in human fetal cardiac myocytes.Methodology/principal findingsUsing antisense inhibition we disrupted the expression of NKX2-5 and studied changes in expression of cardiac-associated genes. Down-regulation of NKX2-5 resulted in increased beta-catenin while GATA4 was decreased. We demonstrated that this regulation was conferred by binding of NKX2-5 to specific elements (NKEs) in the promoter region of the beta-catenin and GATA4 genes. Using promoter-luciferase reporter assay combined with mutational analysis of the NKEs we demonstrated that the identified NKX2-5 binding sites were essential for the suppression of beta-catenin, and upregulation of GATA4 by NKX2-5.ConclusionsThis study suggests that NKX2-5 modulates the beta-catenin and GATA4 transcriptional activities in developing human cardiac myocytes

Microcanonical entropies and radiative strength functions of 50,51^{50,51}V

The level densities and radiative strength functions (RSFs) of $^{50,51}$V have been extracted using the ($^3$He,$\alpha \gamma$) and ($^3$He,$^3$He$^{\prime} \gamma$) reactions, respectively. From the level densities, microcanonical entropies are deduced. The high $\gamma$-energy part of the RSF is described by the giant electric dipole resonance. A significant enhancement over the predicted strength in the region of $E_{\gamma} \lesssim 3$ MeV is seen, which at present has no theoretical explanation.Comment: 16 pages including 9 figure

A co-simulation approach using powerfactory and matlab/simulink to enable validation of distributed control concepts within future power systems

In power network analysis it is increasingly desirable to implement controller and power systems models within different software environments. This stems from, among other things, an increasing influence of new and distrib-uted control functions within smart grids and a growing influence of market operations. The computation time re-sulting from use of multiple simulation environments can cause significant delays and constrain the number of scenarios considered. This paper introduces and com-pares several techniques for integrating external control system models into power systems models for time do-main simulations. In particular, a new technique is reported in this paper for PowerFactory-MATLAB/Simulink co-simulation interfaces, which offers a significant advantage over alternative methods in terms of the reduction in simulation runtimes and flexi-bility for the end user