Analytical investigation of chromium and zinc in sweet, sour and bitter tasting fruits, vegetables and medicinal plants

Sweet, sour and bitter tasting fruits, vegetables and medicinal plants are an important component of human diet. The role of chromium and zinc in carbohydrate metabolism for control of diabetes is highlighted in selected commodities. Average levels of chromium and zinc in sweet taste were 0.69 ± 0.48 mg kg-1 and 4.81 ± 4.31 mg kg-1 respectively with correlation of 0.545, while in sour taste the values were 22.5 ± 22.0 mg kg-1 and 24.5 ± 11.8 mg kg-1 respectively with the correlation of 0.239 and in bitter taste, 0.61 ± 0.33 mg kg-1 and 4.70 ± 3.54 mg kg-1 respectively with correlation of 0.343. Overall, sour tasting commodities were found higher in levels of chromium and zinc and are recommended as food supplement for diabeties. None of these species contain metals above the toxic level

Synthesis and Structure of 4-Chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and Its Metal Complexes

The present study is devoted to the synthesis of 4-chloro-2-{[5-(diethylamino)-2-hydroxybenzylidene]amino}phenol and its transition metal complexes. Synthesis of the ligand has been achieved by the condensation reaction of N,N-diethylsalicylaldehyde with 4-chloro-2-aminophenol in acidic medium. Metals complexes of the ligand with different transition metal ions [M²⁺= Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), and Pd(II)] have been accumulated in alcoholic media and characterized by spectroscopic methods. UV-Vis analysis of the complexes indicates the ligand coordination to the metal ions via both OH groups and the azomethine nitrogen atom, acting as a tridentate ligand. Anticancer tests of selected complexes demonstrate moderate in vitro activity of Cu(II) complex against HeLa cell line.Facultad de Ciencias ExactasInstituto de Física La PlataCentro de Química Inorgánic

Pt, Pd and Cu metal-amidine coordination

Amidines, R’NH-C(R)=NR’, as for the isoelectronic carboxylic acids, form a variety of compounds incorporating transition metals from lower to higher oxidation states. Many studies reveal that Platinum, palladium and copper metals are very active in bonding with amidine moieties. The novelty of work presented here resides in an unified approach that deals with the interpretation of various types of bonding modes shown by amidine moieties and particularly the most remarkable achievements in the design and development of platinum, palladium and copper (II) complexes of substituted amidines. Special emphasis has been focused on the identification of structural relationships for the complexes formed. © 2019 Editura Academiei Romane. All rights reserved

Tetrakis(thiourea-κS)palladium(II) dithiocyanate

The title compound, [Pd(CH4N2S)4](SCN)2, consists of complex [Pd(TU)4]2+ [TU = thiourea, SC(NH2)2] cations and thiocyanate counter-anions. The PdII cation is situated on an inversion centre and exhibits an almost square-planar coordination by the S atoms of the TU ligands. The complex cations are connected through the thiocyanate ions via N—H...N [2.922 (3)–3.056 (3) Å] and N—H...S [3.369 (2)–3.645 (2) Å] hydrogen bonds

Synthesis, spectral characterization and in vitro antibacterial evaluation and Petra/Osiris/Molinspiration analyses of new Palladium(II) iodide complexes with thioamides

The paper emphasizes on the synthesis of Palladium(II) iodide complexes containing based ligands. The new compounds of general formulae [Pd(L)4]I2 where L = Thiourea (Tu), Methylthiourea (Metu), Dimethylthiourea (Dmtu), Tetramethylthiourea (Tmtu), Imidazolidine-2-thione (Imt), Mercaptopyridine (Mpy), Mercaptopyrimidine (Mpm), and Thionicotinamide (Tna) were prepared simply by reacting K2[PdCl4] with the corresponding thioamides in 1:2 M ratio and then with 2 equivalents Potassium iodide. The complexes were characterized by elemental analysis and spectroscopic techniques (IR, 1H and13C NMR). All the synthesized complexes were screened for antibacterial activity and some of compounds have shown good activities against both gram positive and gram negative bacteria. POM analyses reveal that the compounds are only slightly toxic and present a potential for antibacterial activity. Moreover, they have 16–23% drug score which is an important parameter for the compound possessing the drug properties

3-Carbamothioylpyridinium iodide

In the crystal of the title salt, C6H7N2S+·I−, inversion-related cations form an R22(8) dimer linked by a pair of N—H...S hydrogen bonds. Pairs of iodide anions are located between adjacent cation dimers and are linked to them by way of N—H...I hydrogen bonds. This results in zigzag chains propagating in [001] lying parallel to the bc plane

New triorganotin(iv) compounds with aromatic carboxylate ligands: synthesis and evaluation of the pro-apoptotic mechanism.

Three new organotin(iv) carboxylate compounds were synthesized and structurally characterized by elemental analysis and FT-IR and multinuclear NMR (1H, 13C, 119Sn) spectroscopy. Single X-ray crystallography reveals that compound C2 has a monoclinic crystal system with space group P21/c having distorted bipyramidal geometry defined by C3SnO2. The synthesized compounds were screened for drug-DNA interactions via UV-Vis spectroscopy and cyclic voltammetry showing good activity with high binding constants. Theoretical investigations also support the reactivity of the compounds as depicted from natural bond orbital (NBO) analysis using Gaussian 09. Synthesized compounds were initially evaluated on two cancer (HeLa and MCF-7) cell lines and cytotoxicity to normal cells was evaluated using a non-cancerous (BHK-21) cell line. All the compounds were found to be active, with IC50 values less than that of the standard drug i.e. cisplatin. The cytotoxic effect of the most potent compound C2 was confirmed by LDH cytotoxicity assay and fluorescence imaging after PI staining. Apoptotic features in compound C2 treated cancer cells were visualized after DAPI staining while regulation of apoptosis was observed by reactive oxygen species generation, binding of C2 with DNA, a change in mitochondrial membrane potential and expression of activated caspase-9 and caspase-3 in cancer cells. Results are indicative of activation of the intrinsic pathway of apoptosis in C2 treated cancer cells

Synthesis of highly stable MOF-5@MWCNTs nanocomposite with improved hydrophobic properties

Metal-organic frameworks (MOFs) are a promising class of nanoporous crystalline materials with potential applications in gas storage, catalysis, biomedical and clean energy. However, moisture adsorption dampens their structure and therefore capacity and selectivity. Improving the hydrostability of MOF-5 without compromising on its characteristic features can be a potential way to make the best use of this material. In this work, we used a solvothermal method to precipitate MOF-5 in well-dispersed carboxy derived MWCNTs. By inspiring from the hydrophobic properties of carbon nanotubes (CNTs), we have successfully utilized a solvothermal approach to precipitate MOF-5 in well-dispersed carboxy functionalized multiwalled carbon nanotubes (FMWCNTs) to produce a MOF-5@FMWCNTs nanocomposite. The experimental results in this study reveal that the FMWCNTs form stable nanocomposite with MOF-5 particles and the resultant hybrid MOF-5@FMWCNTs nanocomposite indicated an increase in the moisture stability and even after prolonged exposure to ambient moist environment (55% humidity at 28 °C) showed less degradation as confirmed by the BET surface area, and powder XRD studies. So, our findings demonstrate a simple synthetic route to make use of FMWCNTs to stabilize the MOF-5 and it can be a choice for many other MOFs without much compromise on the surface area