Stability indicating method development and validation for the determination of haloperidol and benzhexol by RP-HPLC

A simple, Accurate, precise method was developed for the simultaneous estimation of the Haloperidol and Benzhexol in Tablet dosage form. The chromatogram was run through Kromasil (250mm 4.6mm, 5µ). Mobile phase containing Buffer and Acetonitrile and methanol in the ratio of 48:52 was pumped through column at a flow rate of 1.0 ml/min. The temperature was maintained at 30°C. The optimized wavelength for Haloperidol and Benzhexol was 220nm. The retention time of Haloperidol and Benzhexol were found to be 2.415 min and 2.820min. %RSD of the Haloperidol and Benzhexol were and found to be 0.6 and 0.2 respectively. %Recover was Obtained as 98.92% and 99.60% for Haloperidol and Benzhexol. LOD, LOQ values were obtained from regression equations of Haloperidol and Benzhexol were 0.42ppm, 1.27ppm and 0.04ppm, 0.14ppm respectively. Regression equation of Haloperidol is y = 24009x + 38704, and of Benzhexol is y = 40558x + 2880. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industrie

भारतातील आणि महाराष्ट्रातील पिंजऱ्यातील मत्स्यपैदास : सद्य आणि भविष्यातील प्रगतीच्या संधी

Sea farming is a popular area of aquaculture practice throughout the world. In Asian countries, it is rapidly growing to meet the increasing demand of high value marine fishes. Although India has a tradition of aquaculture, sea farming ventures on commercial scale were lacking. In this context, Central Marine Fisheries Research Institute started open sea floating cage culture activities in 2006-07 with Department of Animal Husbandry, Dairying and Fisheries (DAHD&F), Government of India assistance. Indigenous cage of 15 m diameter was fabricated following Norwegian open sea floating cage design and launched at Visakhapatnam. There was a technical setback with the design of cage, and consultation with Indian Institute of Technology, West Bengal helped to overcome technical issues with the cage structure. Open sea floating cage diameter was reduced to 6 m and 14 new open sea floating cages were launched at Sutrapada (Gujarat), Vasai (Maharashtra), Mangalore (Karnataka), Cochin (Kerala), Pulicat (Tamil Nadu), Nellore, Kakinada, Baruva (Andhra Pradesh) and Balasore (Odisha) in participation with National Fisheries Development Board (NFDB)

Assessment of biogeochemical processes of Ashtamudi Lake ecosystem in relation to clam fishery

The Ashtamudi Lake ecosystem in Kerala (southwest coast of India) is well known for its clam resources. This estuarine system contributes approximately 80% of the total clam export trade of India besides providing livelihoods for at least 3,000 local people. Among bivalves, clams are an important source of meat for human consumption while its shells are used in the cement industry

Mass envenomation during Ganesh idol immersion at Girgaum-Chowpathy beach, Mumbai, Maharashtra

At the end of South-West monsoon along Mumbai coast a swarm of the box jelly fish, Chiropsoides buitendijki was observed during Ganesh idol immersion at Girgaum-Chowpathy beach, Mumbai on 10th September, 2013. The occurrence of such large number of jelly fishes coincided with Ganesh idol immersion, perhaps for the first time in Mumbai waters. Several devotees of Ganesh who congregated at Girgaum-Chowpathy beach for immersion ritual of Ganesh idol were stung by the jelly fish. According to the news paper reports, the devotees moved with the idol in ankledeep water for immersion and immediately thin tentacle-like threads pierced legs and ankles causing severe burning sensation

Occurrence of cystoisosporosis among domestic cats in Thrissur district, Kerala

This study was aimed to evaluate the prevalence of cystoisosporosis among domestic cats in Thrissur district, Kerala. A total of 155 cats were included in this study. Faecal samples collected from all the cats were subjected examination by direct smear method and floatation by Sheather’s sugar solution. Of 155 faecal samples examined, oocysts were found in 28 cats (18.06 per cent). Among these, 12 were collected from cats with signs of gastrointestinal diseases and 16 from cats which are apparently healthy with firm faeces. Mixed infection with Cystoisospora spp and Toxocara, Ancylostoma and Cystoisospora were also detected in three (1.94 per cent) and one (0.65 per cent) cat respectively. Various risk factors associated with the infection were also studied. Prevalence was found to be higher in cats less than six months old. Gender and breed were not affected the prevalence. This study demonstrates that cystoisosporosis is common in cats

Cage culture in maharashtra: present and future prospects

Sea farming is a popular area of aquaculture practice throughout the world. In Asian countries, it is rapidly growing to meet the increasing demand of high value marine fishes. Although India has a tradition of aquaculture, sea farming ventures on commercial scale were lacking. In this context, Central Marine Fisheries Research Institute started open sea floating cage culture activities in 2006-07 with Department of Animal Husbandry, Dairying and Fisheries (DAHD&F), Government of India assistance. Indigenous cage of 15 m diameter was fabricated following Norwegian open sea floating cage design and launched at Visakhapatnam. There was a technical setback with the design of cage, and consultation with Indian Institute of Technology, West Bengal helped to overcome technical issues with the cage structure. Open sea floating cage diameter was reduced to 6 m and 14 new open sea floating cages were launched at Sutrapada (Gujarat), Vasai (Maharashtra), Mangalore (Karnataka), Cochin (Kerala), Pulicat (Tamil Nadu), Nellore, Kakinada, Baruva (Andhra Pradesh) and Balasore (Odisha) in participation with National Fisheries Development Board (NFDB)

Adult immersion test for assessment of amitraz resistance in Rhipicephalus sanguineus ticks

Ticks are obligate blood sucking ectoparasites recognised globally as vectors of various pathogens, next to mosquitoes. The present study is conducted on brown dog ticks collected from naturally infested dogs in and around Thrissur district. Adult immersion test was performed and the parameters such as engorged tick weight, egg mass weight as well as tick mortality were recorded to derive the reproductive indices, percentage inhibition of oviposition and percentage mortalities. Non-linear regression analysis of the dose response data yielded the LC50 values at 95% confidence intervals and, the slopes and regression coefficients of the different parameters were also derived. The Resistance factors (RF) were calculated to categorise resistance levels into I, II, III and IV. Resistance to amitraz was detected at level II in tick isolates collected from Choolissery and Mundur, at level III and level IV in isolates collected from Mannuthy and Paravattani, respectively. Two isolates collected from Mannuthy were found to be susceptible. One way ANOVA of resistance levels revealed that the resistance levels III and IV were significantly different from that of susceptible and resistance level II. This is the first report on detection of amitraz resistance levels in dog ticks from south India calling for proper implementation of tick control strategies to prevent spread of amitraz resistance

Insufficient Rest or Sleep and Its Relation to Cardiovascular Disease, Diabetes and Obesity in a National, Multiethnic Sample

BACKGROUND: A new question on insufficient rest/sleep was included in the 2008 Behavioral Risk Factor Surveillance System (BRFSS) for the 50 states, District of Columbia, and three US territories. No previous study, however, has examined perceived insufficient rest/sleep in relation to cardiovascular disease (CVD) or diabetes mellitus. We examined the association between self-reported insufficient rest/sleep and CVD, diabetes, and obesity in a contemporary sample of US adults. METHODS: Multiethnic, nationally representative, cross-sectional survey (2008 BRFSS) participants were >20 years of age (n=372, 144, 50% women). Self-reported insufficient rest/sleep in the previous month was categorized into four groups: zero, 1-13, 14-29, and 30 days. There were five outcomes: 1) any CVD, 2) coronary heart disease (CHD), 3) stroke, 4) diabetes mellitus, and 5) obesity (body mass index≥30 kg/m2). We employed multivariable logistic regression to calculate odds ratio (OR), (95% confidence interval (CI), of increasing categories of insufficient rest/sleep, taking zero days of insufficient rest/sleep as the referent category. PRINCIPAL FINDINGS: Insufficient rest/sleep was found to be associated with 1) any CVD, 2) CHD, 3) stroke, 4) diabetes mellitus, and 5) obesity, in separate analyses. Compared to those reporting zero days of insufficient sleep (referent), the OR (95% CI) associated with all 30 days of insufficient sleep was 1.67 (1.55-1.79) for any cardiovascular disease, 1.69(1.56-1.83) for CHD, 1.51(1.36-1.68) for stroke, 1.31(1.21-1.41) for diabetes, and 1.51 (1.43-1.59) for obesity. CONCLUSIONS: In a multiethnic sample of US adults, perceived insufficient rest/sleep was found to be independently associated with CHD, stroke, diabetes mellitus and obesity