Cardioprotective effect of pulicaria wightania against isoproterenol induced myocardial infarction in experimental rats

The current study was carried out to evaluate the cardio protective activity of Pulicaria Wightiana against Isoproterenol (ISO) induced myocardial infarction (MI). Pretreatment to the different groups were given for 30 days and ISO was administered at last two days with an interval of 24 hrs. Due to chronic ionotropy ISO induces MI. Blood was collected at the last day of experimental period and biomarkers were observed. The results indicate that the extract exhibited significant cardioprotective activity

Stability indicating method development and validation for the determination of haloperidol and benzhexol by RP-HPLC

A simple, Accurate, precise method was developed for the simultaneous estimation of the Haloperidol and Benzhexol in Tablet dosage form. The chromatogram was run through Kromasil (250mm 4.6mm, 5µ). Mobile phase containing Buffer and Acetonitrile and methanol in the ratio of 48:52 was pumped through column at a flow rate of 1.0 ml/min. The temperature was maintained at 30°C. The optimized wavelength for Haloperidol and Benzhexol was 220nm. The retention time of Haloperidol and Benzhexol were found to be 2.415 min and 2.820min. %RSD of the Haloperidol and Benzhexol were and found to be 0.6 and 0.2 respectively. %Recover was Obtained as 98.92% and 99.60% for Haloperidol and Benzhexol. LOD, LOQ values were obtained from regression equations of Haloperidol and Benzhexol were 0.42ppm, 1.27ppm and 0.04ppm, 0.14ppm respectively. Regression equation of Haloperidol is y = 24009x + 38704, and of Benzhexol is y = 40558x + 2880. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industrie

Assessment of biogeochemical processes of Ashtamudi Lake ecosystem in relation to clam fishery

The Ashtamudi Lake ecosystem in Kerala (southwest coast of India) is well known for its clam resources. This estuarine system contributes approximately 80% of the total clam export trade of India besides providing livelihoods for at least 3,000 local people. Among bivalves, clams are an important source of meat for human consumption while its shells are used in the cement industry

High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program

Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate cancer model, that high-fat diet (HFD) enhances the MYC transcriptional program through metabolic alterations that favour histone H4K20 hypomethylation at the promoter regions of MYC regulated genes, leading to increased cellular proliferation and tumour burden. Saturated fat intake (SFI) is also associated with an enhanced MYC transcriptional signature in prostate cancer patients. The SFI-induced MYC signature independently predicts prostate cancer progression and death. Finally, switching from a high-fat to a low-fat diet, attenuates the MYC transcriptional program in mice. Our findings suggest that in primary prostate cancer, dietary SFI contributes to tumour progression by mimicking MYC over expression, setting the stage for therapeutic approaches involving changes to the diet

Sediment blue carbon stock of Avicennia officinalis in Vembanad Lake ecosystem, Kerala, India

Stock assessment of the blue carbon pool of selected patches of mangrove sediment in the Vembanad Lake was done using the standard protocols on a per ha basis and multiplied with the estimated area to derive the blue carbon stock of the particular fragmented mangrove stands of the species Avicennia officinalis (Indian Mangrove), twice (in the post and pre-monsoon) during October 2017-March 2018. The treatments included ‘aged’, ‘recent’, ‘healthy’ and ‘degraded’ mangroves of the selected species and ‘control’ without mangroves. The overall mean carbon stock in the A. officinalis sediments in selected locations of the Vembanad Lake area was 136.09 Mg C/ha (Mg=mega gram=1 tonne). This value is far low compared to the mean global soil organic carbon stock in the mangrove ecosystem (386 Mg C/ha). This finding suggests ample opportunity for more carbon sequestration in the selected mangrove ecosystems in Vembanad Lake, toward climate change mitigation measures. The treatments differed significantly in the cumulative stock of blue carbon and layer-wise blue carbon density in sediment (p<0.05), the highest seen in ‘healthy’ mangroves in both seasons. The overall range of layer-wise blue carbon density in sediment was found to be 0.003 to 0.56 Mg/m3. Spatial maps prepared for layer-wise blue carbon density in the sediment revealed its depth-wise increase. Layer wise blue carbon stock in sediment had a significant correlation with total organic carbon and organic matter (p<0.01) and with the C/N ratio of the sediment (p < 0.05). Based on the results, this study suggests total organic carbon and the C/N ratio of sediment as possible predictive indicators of sediment blue carbon

Insufficient Rest or Sleep and Its Relation to Cardiovascular Disease, Diabetes and Obesity in a National, Multiethnic Sample

BACKGROUND: A new question on insufficient rest/sleep was included in the 2008 Behavioral Risk Factor Surveillance System (BRFSS) for the 50 states, District of Columbia, and three US territories. No previous study, however, has examined perceived insufficient rest/sleep in relation to cardiovascular disease (CVD) or diabetes mellitus. We examined the association between self-reported insufficient rest/sleep and CVD, diabetes, and obesity in a contemporary sample of US adults. METHODS: Multiethnic, nationally representative, cross-sectional survey (2008 BRFSS) participants were >20 years of age (n=372, 144, 50% women). Self-reported insufficient rest/sleep in the previous month was categorized into four groups: zero, 1-13, 14-29, and 30 days. There were five outcomes: 1) any CVD, 2) coronary heart disease (CHD), 3) stroke, 4) diabetes mellitus, and 5) obesity (body mass index≥30 kg/m2). We employed multivariable logistic regression to calculate odds ratio (OR), (95% confidence interval (CI), of increasing categories of insufficient rest/sleep, taking zero days of insufficient rest/sleep as the referent category. PRINCIPAL FINDINGS: Insufficient rest/sleep was found to be associated with 1) any CVD, 2) CHD, 3) stroke, 4) diabetes mellitus, and 5) obesity, in separate analyses. Compared to those reporting zero days of insufficient sleep (referent), the OR (95% CI) associated with all 30 days of insufficient sleep was 1.67 (1.55-1.79) for any cardiovascular disease, 1.69(1.56-1.83) for CHD, 1.51(1.36-1.68) for stroke, 1.31(1.21-1.41) for diabetes, and 1.51 (1.43-1.59) for obesity. CONCLUSIONS: In a multiethnic sample of US adults, perceived insufficient rest/sleep was found to be independently associated with CHD, stroke, diabetes mellitus and obesity

Status of India's Exploited Marine Fishery Resources in 2013

The Central Marine Fisheries Research Institute start collected and estimation of marine fish landings for the peninsular coast of India since its inception in 1947, based on a stratified multistage random sampling technique. This which continues to date, and provides knowledge-base for many research, planning and policy initiatives in the marine fisheries sector

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Neuroendocrine carcinomas (NEC) are tumors expressing markers of neuronal differentiation that can arise at different anatomic sites but have strong histological and clinical similarities. Here we report the chromatin landscapes of a range of human NECs and show convergence to the activation of a common epigenetic program. With a particular focus on treatment emergent neuroendocrine prostate cancer (NEPC), we analyze cell lines, patient-derived xenograft (PDX) models and human clinical samples to show the existence of two distinct NEPC subtypes based on the expression of the neuronal transcription factors ASCL1 and NEUROD1. While in cell lines and PDX models these subtypes are mutually exclusive, single-cell analysis of human clinical samples exhibits a more complex tumor structure with subtypes coexisting as separate sub-populations within the same tumor. These tumor sub-populations differ genetically and epigenetically contributing to intra- and inter-tumoral heterogeneity in human metastases. Overall, our results provide a deeper understanding of the shared clinicopathological characteristics shown by NECs. Furthermore, the intratumoral heterogeneity of human NEPCs suggests the requirement of simultaneous targeting of coexisting tumor populations as a therapeutic strategy

Design, Performance, and Calibration of the CMS Hadron-Outer Calorimeter

The CMS hadron calorimeter is a sampling calorimeter with brass absorber and plastic scintillator tiles with wavelength shifting fibres for carrying the light to the readout device. The barrel hadron calorimeter is complemented with an outer calorimeter to ensure high energy shower containment in the calorimeter. Fabrication, testing and calibration of the outer hadron calorimeter are carried out keeping in mind its importance in the energy measurement of jets in view of linearity and resolution. It will provide a net improvement in missing \et measurements at LHC energies. The outer hadron calorimeter will also be used for the muon trigger in coincidence with other muon chambers in CMS