The death of the non-native speaker? English as a lingua franca in business communication: A research agenda

Copyright © Cambridge University Press 2015. The impact of globalisation in the last 20 years has led to an overwhelming increase in the use of English as the medium through which many business people get their work done. As a result, the linguistic landscape within which we now operate as researchers and teachers has changed both rapidly and beyond all recognition. In the discussion below, I will outline a research agenda for English as a lingua franca (ELF) in business communication of relevance for scholars and practitioners with an interest in teaching language. I will discuss three main areas of enquiry, which are: (1) the further development of the existing theory concerning the use of English in business and how this impacts language teaching, including the role played by native speakers of English, (2) the influence of culture and context on the production and interpretation of English in business contexts, and (3) the extension of our existing understanding of the use of English in business contexts in order to take increasingly advanced levels of proficiency into account, as well as developing an understanding of what constitutes professional communicative competence in business. For each of these key areas I will suggest a number of tasks which could help to give substance to our research in the future

Cross-sectional Survey of Medical student perceptions of And desires for Research and Training pathways (SMART): an analysis of prospective cohort study of UK medical students

Objective: Clinician-scientists are critical to medical innovation and research. However, the number of clinician scientists in the UK has been declining steadily over the last decade. One of the cited reasons is poor student recruitment to academic training pathways. The SMART study aims to assess current student perceptions on research and identify key factors influencing whether a student is interested in research. Design: We conducted a cross-sectional survey study between January and May 2022. Setting: This was a multi-centre national study with data collected across 40 universities offering medical courses in the UK. Participants: Participants were UK medical students enrolled in medicine for 21/22 academic year. Main outcome and measure: The main outcomes were related to participant perceptions on research and whether they were interested in engaging with research in their future career. These measures were correlated with demographic and non-demographic details using regression analyses. Results: One thousand seven hundred seventy-four individuals participated in the SMART survey from 40 medical schools. Nearly half the participants felt there were barriers preventing them from doing research (46.67%) and almost three-quarters felt it was at least somewhat difficult to combine research with medical school (73.49%). Of the options available, most commonly students did not want to pursue an academic career (43.11%) or training pathway (42.49%). However, most participants felt it was useful to do research at medical school (59.54%) and were also interested in doing more research in the future (69.16%). Regression analysis identified many factors influencing student’s perceptions of research including year of study, gender, socioeconomic status, family background, research exposure at medical school, ethnicity, and country of pre-university education. Conclusions: The SMART study is the first of its kind in the UK, shedding light on medical student perceptions. While some express strong interest in academic careers, a larger proportion show a broader interest in research. Demographic factors like gender, parental occupation, and socioeconomic status play a role. Further exploration is needed for specific groups to address barriers, promote research, and boost academic pathway recruitment

Concurrent Oral 9 - Rheumatoid Arthritis: Aetiopathogenesis [OP59-OP64]: OP59. The Value of Interleukin-17 Serum Level in Rheumatoid Arthritis Immunopathogenesis

Background: Interleukin (IL)-17 is the main Th-1 cytokine, produced by activated T-lymphocytes. The potential IL-17 value in rheumatoid arthritis (RA) pathogenesis consists of its independent inflammatory response induction and mediated stimulation of proinflammatory factors synthesis resulting in joint destruction. The aim of study was to determine the role of IL-17 in immuno-inflammatory/autoimmune reactions development and to reveal IL-17 serum level associations with clinical and immunological characteristics of RA. Methods: 50 patients with early RA (disease duration >, Russia), anti-CCP antibodies (Axies-Shield Diagnostic, UK) were revealed using ELISA immunoassay. Results: On the base of IL-17 serum level patients were divided in two groups: group1 (n = 28) were patients with normal IL-17 serum level and group2 (n = 22) were those with high IL-17 serum level. In the group2, the rate of patients' pain assessment by visual analogue scale (67.3 ± 7.2 vs 32.8 ± 4.6; P < 0.001), tender (16.7 ± 2.0 vs 8.4 ± 1.1; P < 0.01) and swollen (12.3 ± 2.3 vs 3.9 ± 0.8; P < 0.01) joint count, DAS28 (5.0 ± 0.4 vs 2.8 ± 0.2 P < 0.01) were significantly higher compare to group1. It was found that in group2 the higher T-lymphocyte amount (CD3) was due to CD4 higher quantity, at the same time CD8 amount was significantly lower (22.2 ± 1.5% vs 28.4 ± 1.7%, P < 0.05) compare to group1. This caused the immunoregulative index increasing and indicated in the lost of autoimmune process regulation, including B-lymphocytes (CD19) activation. The CD154 expression was significantly lower in the group2 (3.4 ± 0.4% vs 10.8 ± 2.8%, P < 0.05) compare to group1. The difference in autoimmune reaction indices wasn't significant between groups except antibody-producing B-lymphocytes (13.7 ± 1.5% vs 8.5 ± 1.0%, P < 0.05) and IgM RF serum level (2.9 ± 0.3 U/ml vs 1.6 ± 0.5 U/ml, P < 0.05), which were significantly higher in group1. The IL-17 level had a positive correlative connections with DAS28 (r = 0.7; P < 0.05), circulative immune complex level (r = 0.38; P < 0.05), anti-CCP antibodies (r = 0.4; P < 0.05), IgM RF (r = 0.41; P < 0.05), CD4 (r = 0.38; P < 0.05) and negative correlative connection with CD8 (r = -0.39; P < 0.05). Conclusions: The importance of IL-17 value in immuno-inflammatory and autoimmune reactions development through T-lymphocytes activation in RA pathogenesis was confirmed. Thus the influence on T-depended immuno-inflammatory reaction products synthesis could be a new therapeutic target of RA patients' management. Disclosure statement: All authors have declared no conflicts of interes

The posterior lobe of the monkey cerebellum: Anatomical connections and their functional implications

The cerebellum links visual and motor structures in the brain and plays a critical role in visuo-motor co-ordination. Mossy fibre-mediated visual information is transmitted to the posterior lobe of the cerebellum via the dorsolateral pons (dlpn). Anterograde tracing studies have demonstrated that the dlpn projects heavily to the dorsal paraflocculus (dpf), and moderately to the posterior vermis and hemispheres. The projection to the flocculus is virtually non-existent, but it receives climbing fibre-mediated visual information via the dorsal cap of the inferior olive. Sixteen monkeys received injections of the bi-directional tracer WGA-HRP into cerebellar cortical areas receiving mossy or climbing-fibre mediated visual information. The following questions were addressed: i) Do retrograde studies confirm the absence of floccular projections from the dlpn? ii) How is the olivo-cortico-nuclear parasagittal zonation represented in the monkey? iii) Do cerebellar cortical projections overlap in the deep cerebellar nuclei? The results suggest that the flocculus only receives a sparse collateral input from the dlpn. The olivo-cortico-nuclear system in the monkey is shown to diverge beyond the strict parasagittal zonation seen in non-primates, allowing cross-talk between functional modules. In addition, cortico-nuclear projections from different cortical regions overlap. Indeed, hemispheric eye-movement related areas (dpf, flocculus and crus II) all project to the ventrocaudal posterior interposed nucleus, a discrete eye movement region involved in the control of vertical saccades and the far-response in vergence and accommodation (Van Kan et al., '93; Zhang and Gamlin, '94; Robinson et al., '96). Vermal lobule VII projects to the fastigial oculomotor region of Noda et al. ('88), which controls horizontal saccades and the near-response (Robinson et al., '93; Zhang and Gamlin, '96). Finally, additional observations on cortico-nuclear topography demonstrate how multiple somatotopies in the cortex (e.g. multiple eye movement areas) are reduced onto a single representation of the body in each of the deep cerebellar nuclei

At a Glance Reumatologi, Ortopedi, dan Trauma

117 hal. : il. ; 28 cm

At a Glance reumatologi, ortopedi, dan trauma/ Swales

117 hal.: ill, tab.; 29 cm

At a Glance reumatologi, ortopedi, dan trauma/ Swales

117 hal.: ill, tab.; 29 cm

At a Glance reumatologi, ortopedi, dan trauma/ Swales

117 hal.: ill, tab.; 29 cm