Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs

It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this substance, since the suppression of the AF coincides with its anticholinergic effect observed for more than 2 hours, but cardiotropic action at this time was not observed. High antiarrhythmic activity of SS-68 to neurogenic AF may be due to the IKAch inhibition and blockade of M2-cholinergic receptor

Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/ MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practic

Distance learning: opportunities and challenges in quarantine.

The urgent introduction of distance education into the learning process due to the COVID-19 pandemic has become a spontaneous experiment, requiring urgent decisions, effective mechanisms to implement into the educational process and analysis of ongoing educational process. The possibilities of modern digital technologies made it possible to quickly set up the information component of education and to controle student’s knowledge. A detailed analysis of the communication between the faculty members of the department among themselves and analysis of the features of teaching and self-education of students in the field of medical radiology and oncology based on answers and comments with using Google classroom, Socrative, Messenger Telegram, etc. was made. Issues of communicative interaction between faculty members and students, psychological aspects of distance communication, language of instruction, logistics of distance education and methodological problems are described in details. It has been suggested that distance education may be equally effective for theoretical subjects in full-time study form, but when studying clinical disciplines, the priority should be given to traditional methods of teaching, involving student's bedside training. Taking into account technical possibilities and high risk of development of extreme and emergency situations, it is suggested to introduce permanent readiness for distance education, to create all – Ukrainian distance imitation service of patients’ follow-up. The importance of using the state language in training as the basis for mastering the professional Ukrainian and English language as the basis for mastering international medical experience is indicated

MAGNETIC RELAXATIONAL BEHAVIOUR IN Fe3+ DOPED POLYVINYLPYRIDINE

Des mesures d'effet Mössbauer et d'aimantation ont été faites sur de la polyvinylpyridine dopée avec des ions Fe3+ (0,l ; 0,8 et 3% en poids). Les spectres de relaxation magnétique observés en dessous d'environ 10 K sont interprétés comme provenant d'une réduction du temps d'inversion de l'aimantation résultante des régions amorphes ordonnées spéromagnétiquement. Ce comportement magnétique trouve son origine dans la variation de l'angle et de la longueur de liaison des différents ions Fe3+.Mössbauer and magnetization measurements have been performed on polyvinylpyridine doped with Fe3+ ions (0.1, 0.8 and 3 wt %). The magnetic relaxation spectra observed below ~ 10 K are interpreted as arising from a reduction in the flipping time of the resultant magnetization of speromagnetically ordered amorphous regions. This magnetic behaviour originates from the variation in bond angle and bond length of different Fe3+ ions

Anticholinergic activity and pharmacokinetic parameters of agent SS-68 with properties of class III antiarrhythmic drugs

It was shown that the indole derivate SS-68 (50 and 250 μg/kg intravenous) in acute experiments on cats with neurogenic atrial fibrillation (AF) has a dose-dependent antiarrhythmic action which is associated with the neurotropic influence of this substance, since the suppression of the AF coincides with its anticholinergic effect observed for more than 2 hours, but cardiotropic action at this time was not observed. High antiarrhythmic activity of SS-68 to neurogenic AF may be due to the IKAch inhibition and blockade of M2-cholinergic receptor

Pharmacokinetic studies derived indole SS-68 with antiarrhythmic and antianginal properties

A method of quantitative determination of SS-68 derivative of indole in rabbit blood plasma by high performance liquid chromatography with tandem mass spectrometric detector (HPLCMS/ MS). Conducted pharmacokinetic studies SS-68 in the body of rabbits. Set the main pharmacokinetic parameters of the substance that allow you to optimize the future use of it’s as a potential drug in cardiology practic