30 research outputs found
Exploring Faculty Mindsets in Equity-Oriented Assessment
The COVID-19 pandemic and the resultant move to remote learning in 2020-2021 paved the way for deeper conversations about assessment practices in higher education. Over the last two years, there have been an increasing number of discussions about alternative assessments and about equity in assessment. This study examined the impact of a course (entitled âEquity in Assessmentâ) delivered by the authors on the participantsâ understandings of equity and assessment. We used semi-structured interviews to collect data from the participants. Data collected from six interviews were systematically and thematically analysed in line with Braun and Clarkeâs (2006) six stages of conducting thematic analyses. The data analysis resulted in three main emergent themes: flexibility, academic rigour, and wellness. The implications of the findings of this project are important for educational developers, institutional leadership, and researchers
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
The Production and Use of Administrative Documents in Somerset from Glanvill to Magna Carta
The Production and Use of Administrative Documents in Somerset from Glanvill to Magna Carta
Robin Sutherland-Harris
Doctor of Philosophy
Centre for Medieval Studies
University of Toronto
2016
Abstract
This thesis studies how various kinds of administrative documents were produced and used through the late twelfth and early thirteenth centuries within the geographical and administrative territory bounded by the shire of Somerset and the diocese of Bath and Wells. Documents were increasingly part of administration in medieval England at all levels, from royal government to the local land market, from archbishops to cathedral canons. Parallel to the growing importance of administrative texts, an increasingly regularized body of administrative personnel also emerged during the twelfth and thirteenth centuries. This thesis is therefore situated in the intersection of a flourishing documentary culture and a burgeoning administrative class. Theoretical frameworks provided by scholarship on the partial shift from memory to the written word, on textual communities, and on pragmatic literacy inform the analysis throughout.
Focussing on the production and use of administrative documents over a short time period and in a specific region makes it possible to approach them in detail and at multiple levels. At the level of the institution, both the diocese of Bath and Wells and the monastery of Glastonbury made use of administrative documents while in conflict with one another. At the level of the individual, the archdeacons of the diocese found a range of administrative roles in royal government, in which they relied on pragmatic literacies tailored to their individual circumstances. At the level of the documents themselves, connections between surviving charter originals reveal the articulation of large-scale changes in documentary and administrative culture in the uneven small-scale nuances of scribal and chancery production. Each chapter examines documentary culture and pragmatic literacy in the local context, exposing bureaucratic rather than literary or religious reading communities. Rather than the high-culture focus adopted by most studies of medieval literacy, the emphasis here is on the more wide-spread and practically engaged world of administrative bodies, personnel, and documents; this allows a Ăą core sampleĂą of evidence from a local temporal and geographical microcosm to be tested against our understanding of macrocosmic changes in the uses of texts and the roles of literacy in the medieval west.Ph.D.2019-11-07 00:00:0
2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer
2-Methoxyestradiol Is an Estrogen Receptor Agonist That Supports Tumor Growth in Murine Xenograft Models of Breast Cancer
The Exeterâą Universal Hip in Patients 50 Years or Younger at 10â17 Yearsâ Followup
The Exeterâą Universal hip (Stryker Inc., Newbury, UK) has reported survival rates of 91.74% at 12Â years in all patients with reoperation as an endpoint. However, its performance in younger patients has not been fully established. We reviewed survivorship and the clinical and radiographic outcomes of this hip system implanted in 107 patients (130 hips) 50Â years old or younger at the time of surgery. The mean age at surgery was 42Â years. The minimum followup was 10Â years (mean, 12.5Â years; range, 10â17Â years) with no patients lost to followup. Twelve hips had been revised. Of these, nine had aseptic loosening of the acetabular component and one cup was revised for focal lysis and pain. One hip was revised for recurrent dislocation and one joint underwent revision for infection. Radiographs demonstrated 14 (12.8%) of the remaining acetabular prostheses were loose but no femoral components were loose. Survivorship of both stem and cup from all causes was 92.6% at an average of 12.5Â years. Survivorship of the stem from all causes was 99% and no stem was revised for aseptic loosening. The Exeterâą Universal stem performed well, even in the young, high-demand patient
Ten-year results with the Morscher press-fit cup: an uncemented, non-modular, porous-coated cup inserted without screws
Total hip arthroplasty (THA) with well designed cementless acetabular implants has shown excellent results. The purpose of this study was to assess our clinical and radiological outcomes using an uncemented cup. We conducted a prospective cohort study including all consecutive primary THAs performed with the Morscher press-fit cup, an uncemented non-modular acetabular component, between March 1996 and December 1998. Patients were evaluated at ten years with clinical and radiological follow-up, patient satisfaction and questionnaire assessment using the Harris hip score (HHS), Merle dâAubignĂ© and Postel score, the UCLA score, the 12-item short-form health survey (SF-12) and a visual analog scale. Five hundred sixty-one THAs were performed in 518 patients. At 120 months (± 7.3 months), 303 patients with 335 THAs were still available for follow-up. None of the patients had required cup revision for aseptic loosening. At ten years, the cup survivorship was 98.8% (95% CI 97.4â99.5) with cup revision for any cause as an endpoint. No radiolucencies were seen around the cups, but osteolytic defects involved 21 stems (8.3%). Mean total linear polyethylene wear was 0.9 mm. The Morscher acetabular replacement cup provides excellent results at ten years. There were no revisions for aseptic loosening of the cup, and no osteolytic defects were found around the cup. Patient satisfaction was high and the clinical results were very good