Extracorporeal Shock Wave Therapy (ESWT) as a treatment for recurrent Neurogenic Heterotopic Ossification (NHO)

“This is an Accepted Manuscript of an article published by Taylor & Francis in Brain Injury on 5 Feb 2013, available online: http://www.tandfonline.com/10.3109/02699052.2012.729293." © 2013 Informa UK Ltd.Primary objective: To describe the effects of extracorporeal shock wave therapy (ESWT) on neurogenic heterotopic ossification (NHO). Research design: A single case study was considered the most appropriate methodology in this situation. Methods and procedures: The subject was a 43 year old female 10 years post-traumatic brain injury with recurring NHO around the hip joint. Baseline assessments of pain using a 10-point VAS, range of motion of the hip using a goniometer and walking ability (number of steps over a standard distance) were conducted. Four applications of ESWT using a Minispec™ Extracorporeal Shock Wave Lithotripsy machine (Medispec Int. USA) administered over 6 weeks to the anterolateral aspect of the right hip. Follow-up assessments were conducted weekly over the period of intervention and then monthly for 5 months. Main outcomes and results: Immediately following treatment, pain was reduced to 0 on the VAS scale; hip range of motion increased and the number of steps over a standard distance reduced, indicating increased step length. At 5-month follow-up, without further ESWT intervention, these results were maintained. Conclusion: This case study suggests that ESWT may be a non-invasive, low risk intervention for the management of NHO

The incidence and make up of ability grouped sets in the UK primary school

The adoption of setting in the primary school (pupils ability grouped across classes for particular subjects) emerged during the 1990s as a means to raise standards. Recent research based on 8875 children in the Millennium Cohort Study showed that 25.8% of children in Year 2 were set for literacy and mathematics and a further 11.2% of children were set for mathematics or literacy alone. Logistic regression analysis showed that the best predictors of being in the top set for literacy or mathematics were whether the child was born in the Autumn or Winter and cognitive ability scores. Boys were significantly more likely than girls to be in the bottom literacy set. Family circumstances held less importance for setting placement compared with the child’s own characteristics, although they were more important in relation to bottom set placement. Children in bottom sets were significantly more likely to be part of a long-term single parent household, have experienced poverty, and not to have a mother with qualifications at NVQ3 or higher levels. The findings are discussed in relation to earlier research and the implications for schools are set out

Observations of GEO Debris with the Magellan 6.5-m Telescopes

Optical observations of geosynchronous orbit (GEO) debris are important to address two questions: 1. What is the distribution function of objects at GEO as a function of brightness? With some assumptions, this can be used to infer a size distribution. 2. Can we determine what the likely composition of individual GEO debris pieces is from studies of the spectral reflectance of these objects? In this paper we report on optical observations with the 6.5-m Magellan telescopes at Las Campanas Observatory in Chile that attempt to answer both questions. Imaging observations over a 0.5 degree diameter field-of-view have detected a significant population of optically faint debris candidates with R > 19th magnitude, corresponding to a size smaller than 20 cm assuming an albedo of 0.175. Many of these objects show brightness variations larger than a factor of 2, suggesting either irregular shapes or albedo variations or both. The object detection rate (per square degree per hour) shows an increase over the rate measured in the 0.6-m MODEST observations, implying an increase in the population at optically fainter levels. Assuming that the albedo distribution is the same for both samples, this corresponds to an increase in the population of smaller size debris. To study the second issue, calibrated reflectance spectroscopy has been obtained of a sample of GEO and near GEO objects with orbits in the public U.S. Space Surveillance Network catalog. With a 6.5-m telescope, the exposures times are short (30 seconds or less), and provide simultaneous wavelength coverage from 4500 to 8000 Angstroms. If the observed objects are tumbling, then simultaneous coverage and short exposure times are essential for a realistic assessment of the object fs spectral signature. We will compare the calibrated spectra with lab-based measurements of simple spacecraft surfaces composed of a single material

Optical Reflection Spectroscopy of GEO Objects

We report on optical reflection spectroscopy of geosynchronous (GEO) objects in the US Space Surveillance Network (SSN) catalog. These observations were obtained using imaging spectrographs on the 6.5-m Magellan telescopes at the Las Campanas Observatory in Chile. Our goal is to determine the composition of these objects by comparing these spectral observations with ground-based laboratory measurements of spacecraft materials. The observations are all low resolution (1 nm after smoothing) obtained through a 5 arcsecond wide slit and using a grism as the dispersing element. The spectral range covered was from 450 nm to 800 nm. All spectra were flux calibrated using observations of standard stars with the exact same instrumental setup. An effort was made to obtain all observations within a limited range of topocentric phase angle, although the solar incident angle is unknown due to the lack of any knowledge of the attitude of the observed surface at the time of observation

Comparisons of a Constrained Least Squares Model Versus Human-in-the-Loop for Spectral Unmixing to Determine Material Type of GEO Debris

Spectral reflectance data through the visible regime was collected at Las Campanas Observatory in Chile using an imaging spectrograph on one of the twin 6.5-m Magellan telescopes. The data were obtained on 1-2 May 2012 on the 'Landon Clay' telescope with the LDSS3 (Low Dispersion Survey Spectrograph 3). Five pieces of Geosynchronous Orbit (GEO) or near-GEO debris were identified and observed with an exposure time of 30 seconds on average. In addition, laboratory spectral reflectance data was collected using an Analytical Spectral Device (ASD) field spectrometer at California Polytechnic State University in San Luis Obispo on several typical common spacecraft materials including solar cells, circuit boards, various Kapton materials used for multi-layer insulation, and various paints. The remotely collected data and the laboratory-acquired data were then incorporated in a newly developed model that uses a constrained least squares method to unmix the spectrum in specific material components. The results of this model are compared to the previous method of a human-in-the-loop (considered here the traditional method) that identifies possible material components by varying the materials and percentages until a spectral match is obtained. The traditional model was found to match the remotely collected spectral data after it had been divided by the continuum to remove the space weathering effects, or a "reddening" of the materials. The constrained least-squares model also used the de-reddened spectra as inputs and the results were consistent with those obtained through the traditional method. For comparison, a first-order examination of including reddening effects into the constrained least-squares model will be explored and comparisons to the remotely collected data will be examined. The identification of each object's suspected material component will be discussed herein

Changing expendable bathythermograph fall rates and their impact on estimates of thermosteric sea level rise

A time-varying warm bias in the global XBT data archive is demonstrated to be largely due to changes in the fall rate of XBT probes likely associated with small manufacturing changes at the factory. Deep-reaching XBTs have a different fall rate history than shallow XBTs. Fall rates were fastest in the early 1970s, reached a minimum between 1975 and 1985, reached another maximum in the late 1980s and early 1990s, and have been declining since. Field XBT/CTD intercomparisons and a pseudoprofile technique based on satellite altimetry largely confirm this time history. A global correction is presented and applied to estimates of the thermosteric component of sea level rise. The XBT fall rate minimum from 1975 to 1985 appears as a 10-yr “warm period” in the global ocean in thermosteric sea level and heat content estimates using uncorrected data. Upon correction, the thermosteric sea level curve has reduced decadal variability and a larger, steadier long-term trend

Searching for Optically Faint GEO Debris

We report on results from a search for optically faint debris (defined as R > 20th magnitude, or smaller than 10 cm assuming an albedo of 0.175)) at geosynchronous orbit (GEO) using the 6.5-m Magellan telescope "Walter Baade" at Las Campanas Observatory in Chile. Our goal is to characterize the brightness distribution of debris to the faintest limiting magnitude possible. Our data was obtained during 6 hours of observing time during the photometric nights of 26 and 27 March 2011 with the IMACS f/2 instrument, which has a field of view (fov) of 0.5 degrees in diameter. All observations were obtained through a Sloan r filter, and calibrated by observations of Landolt standard stars. Our primary objective was to search for optically faint objects from one of the few known fragmentations at GEO: the Titan 3C Transtage (1968-081) fragmentation in 1992. Eight debris pieces and the parent rocket body are in the Space Surveillance Network public catalog. We successfully tracked two cataloged pieces of Titan debris with the 6.5-m telescope, followed by a survey for unknown objects on similar orbits but with different mean anomalies. To establish the bright end of the debris population, calibrated observations were acquired on the same field centers, telescope rates, and time period with a similar filter on the 0.6-m MODEST (Michigan Orbital DEbris Survey Telescope), located 100 km to the south of Magellan at Cerro Tololo Inter-American Observatory, Chile. We will show the calibrated brightness distributions from both telescopes, and compare the observed brightness distributions with that predicted for various population models of debris of different sizes

Plant-expressed Hepatitis B core antigen virus-like particles: Characterization and investigation of their stability in simulated and pig gastro-intestinal fluids

Virus-like particles (VLPs) are potential oral vaccine candidates, as their highly compact structure may allow them to withstand the harsh conditions of the gastro-intestinal (GI) environment. Hepatitis B core antigen (HBcAg) is an immunogenic protein that assembles into 30 or 34 nm diameter VLPs. Here, the stabilities of both the HBcAg polypeptide itself and the three-dimensional structure of the VLPs upon exposure to in vitro and ex vivo simulated gastric and intestinal fluids were investigated. Plant-expressed HBcAg VLPs were efficiently purified by sucrose density gradient and characterized. The purified VLPs did not show major chemical or physical instability upon exposure to the low pH conditions typically found in the stomach; however, they completely agglomerated upon acidification and subsequent pH neutralization. The HBcAg polypeptide was highly digested upon exposure to pepsin in simulated gastric fluids. HBcAg appeared more stable in both simulated and ex vivo intestinal fluids, where despite a partial digestion of the HBcAg polypeptide, the VLPs maintained their most immunogenic epitopes and their particulate conformation. These results suggest that HBcAg VLPs are likely to be unstable in gastric fluids, yet if the gastric instability could be bypassed, they could maintain their particulate structure and immunogenicity in intestinal fluids

Secondary school pupils' preferences for different types of structured grouping practices

The aim of this paper is to explore pupils’ preferences for particular types of grouping practices an area neglected in earlier research focusing on the personal and social outcomes of ability grouping. The sample comprised over 5,000 year 9 pupils (aged 13-14 years) in 45 mixed secondary comprehensive schools in England. The schools represented three levels of ability grouping in the lower school (years 7 to 9). Pupils responded to a questionnaire which explored the types of grouping that they preferred and the reasons for their choices. The majority of pupils preferred setting, although this was mediated by their set placement, type of school, socio-economic status and gender. The key reason given for this preference was that it enabled work to be matched to learning needs. The paper considers whether there are other ways of achieving this avoiding the negative social and personal outcomes of setting for some pupils