EVALUASI PENGGUNAAN OBAT ANTI HIPERTENSI PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS

The intervention led to various complications in dialysis patients includehypertension intradialitik as a result of hemodynamic changes.The phenomenon of theparadox of which caused activation of endogenous vasopresor due to changes involume status and antihypertensive medication terdialisisnya factor. This study aims todetermine patterns of use of antihypertensive drugs, evaluating the rationality and sideeffects of antihypertensive drugs based on literarur. This study was performed with thepatient’s condition based on the observation of patients to see medical records drugdata, laboratory data of patients and patient’s condition.Retrospective study ofhemodialysis patients in the hospital PKU Muhammadiyah Yogyakarta year periodfrom 2009 to 2010. Patients according to inclusion criteria, anti-hypertensive drugreceipts and complete medical record data. Evaluation of rationality involves the use ofantihypertensive drugs right dose, right patient and side effects based on the DrugInformation Hand Book 2005, Handbook of Clinical Drug Data, 2002. The study found60 patients who fit the inclusion criteria. Based on the research patterns of use ofantihypertensive drugs in patients with hemodialysis is captoril, furosemide, nifedipine,lisinopril, amlodipine, valsatran and clonidin. Evaluation rationality inappropriate useof drugs dose use of captopril 11 patients of 34 patients and furosemide 18 patients from52 patients, inappropriate use of captopril patients was 9 patients of 34 patients.Sideeffects that occur in patients with hypokalemia due to the use of furosemide is 40patients, cough due to captopril was 13 patients, side effects of nifedipinegastrointestinal disorders cough and 11 patients, 5 patients coughlisinopril. Conclusion:he use of antihypertensive medications in hemodialysispatientsat RSU PKU Muhammadiyah Yogyakarta is rational

KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010

Drug interactions are one of the Drug Related Problems (DRPs) that may affectpatient treatment outcomes. Hypertension occurs in approximately 10% to 81.5% ofhemodialysis patients. The purpose of this study was to determine the incidence ofantihypertensive drug interactions in hemodialysis patients in the inpatient wards PKUMuhammadiyah Hospital of Yogyakarta period in 2010. This study descriptive design.Data retrieved retrospectively. Data retrieval were done by taking all the data thatmeet the criteria of existing research on the medical records of hemodialysis patients inPKU Muhammadiyah Hospital of Yogyakarta who received antihypertensive withabove normal blood pressure (= 130/80 mmHg). Data were analyzed based on thedescriptive level of significance, onset, and severity. The results showed that there were54.79% (40 patients) of 73 hemodialysis patients potentially experienced druginteractions. Antihypertensive drugs most widely used in hemodialysis patients wereACEI, CCB, and diuretics. Incidence of antihypertensive drug interactions 27 cases(45.76% were most common at a significance level 3, 48 cases (81.36%) were onsetdelayed, and the severity minor of 44 cases (74.58%). The mechanism of interactionspharmacodynamic were 37 cases (62.71%) of the total 59 events that have druginteractions. Drugs often interactions were furosemide and captopril

PENGARUH PEMBERIAN INFORMASI OBAT TERHADAP TINGKAT KEPATUHAN PENGGUNAAN ANTIBIOTIKA PADA PASIEN ISPA DI PUSKESMAS KOTAGEDE I YOGYAKARTA

ARI is an acute respiratory infection requiring antibiotics. The use of antibiotics shouldbe routinely to prevent resistance. The design of this research was experimental by treatment ofthe cases. How to collect the data used prospective method. The subjects of research who fulfilthe inclusion criteria were 44 patients with acute respiratory infection were divided into twogroups: 22 patients who were given information as the treatment group and 22 patients whowere not given information as the control group. Data was collected through interview to knowthe rest of the drug and questionnaires filling compliance with Modification Morisky AdherenceScale (MMAS). The pattern for antibiotic used in patients of acute respiratory infection atcommunity health centre Kotagede I Yogyakarta were Amoxicillin (65.9%), Cotrimoksazol (25%), Erithromycin (6.8%), and Ciprofloxacin (2.3%). The level of patients compliance byquestionnaire MMAS was 59.09% high compliance, and 40.91 % low compliance. The level ofpatients compliance by the rest of drug was 86.36% and patients uncompliance was 11.36%.The results of questionnaire MMAS with the Chi-Square test p=0.220 (p>0.05), this shows thatgiving drug informations had no influence to level compliance for antibiotic used in patiens ofacute respiratory infection at Community Health Centre Kotagede I Yogyakarta

GAMBARAN PENGGUNAAN OBAT PASIEN PENYAKIT GINJAL KRONIK DI INSTALASI RAWAT INAP RS PKU MUHAMMADIYAH GAMPING

Penyakit ginjal kronik (PGK) merupakan penurunan fungsi ginjal secara progesif dan sudah berlangsung lama. Pada pasien PGK membutuhkan terapi yang tepat dan aman untuk mencegah terjadinya akumulasi obat akibat gangguan ekskresi obat melalui ginjal. Penelitian ini bertujuan untuk mengetahui karakteristik pasien PGK, golongan obat, jenis obat dan obat yang bersifat kontraindikasi pada pasien PGK di instalasi Rawat Inap RS PKU Muhammadiyah Gamping. Metode penelitian yang digunakan adalah metode observasional deskriptif dengan mendeskripsikan karakteristik dan penggunaan obat pasien PGK. Pengambilan data secara retrospektif meliputi penggunaan obat dan data rekam medik pasien PGK di instalasi rawat inap PKU Muhammadiyah Gamping tahun 2019. Jumlah sampel di tentukan dengan rumus slovin diperoleh 41 rekam medik pasien PGK dengan teknik purposive sampling sesuai dengan kriteria inklusi pasien. Data dianalisis dengan cara deskriptif dalam bentuk persentase meliputi karakteristik pasien, golongan obat, jenis obat dan obat yang dikontraindikasikan terhadap pasien PGK. Hasil penelitian dari 41 pasien menunjukan bahwa karakteristik dengan persentase tertinggi berdasarkan usia adalah 45-59 tahun 20 pasien (48,78%), jenis kelamin laki-laki 28 pasien (68,29%). Berdasarkan penyakit penyerta yaitu hipertensi 14 pasien (34,14%), jumlah penggunaan obat terbanyak yaitu 6-10 obat (39,02%). Pada golongan dan jenis obat terbanyak yaitu sistem kardiovaskular dan hematopoietik terdapat 100 jumlah pemberian (32,78%). Penggunaan obat yang dikontraindikasikan pada pasien PGK adalah ketorolac, asam mefenamat dan spironolactone. Kesimpulan penelitian ini adalah penggunaan obat yang bersifat kontraindikasi yaitu ketorolac, asam mefenamat dan spironolactone

GAMBARAN PASIEN GERIATRI MELAKUKAN SWAMEDIKASI DI KABUPATEN SLEMAN

The increase in life expectancy caused geriatric population is also increasing. Geriatric patient is identicalto the decline in physiological function that can lead to various diseases. Self medication in geriatric requirespecial attention from the pharmacist. The purpose of this study was to determine the description of geriatric thatdoes self medication and assosation factors in geriatric patients doing the self medication in Sleman. This researchwas conducted using a survey to determine the presence of pharmacy in Sleman. Determination of pharmaciesconducted with a purposive sampling technique and determination of areas of research subjects or respondentswith accidental sampling. Subjects were geriatric patients with age> 60 years who did self medication inpharmacies. The data were analyzed by using chi-square statistic to determine which are the most influentialassociation factors. The research subjects in this study was 38 respondents. The pattern of disease that occur ingeriatric patients who performs a self-medication is a chronic 12 respondens, non-respondens and 16 non chronicrespondens ten respondens is unknown. Factors that association geriatric patients that is doing self medication isown of health insurance. The results of the chi square test showed that the sex factor with OR 1,11 ( p >0,05),ownership asurance (OR = 1,841,p < 0,05,CI : 1,184 – 2,184) is a factor of self association with geriatric patientsmedications at the pharmacy of district Sleman

Evaluation of erythropoietin therapy in hemodialysis patients at PKU Muhammadiyah Hospital Yogyakarta

Most of the patients with end-stage renal disease who undergo hemodialysis receive erythropoietin (EPO) therapy for anemia treatment. Anemia with EPO deficiency is a common complication of chronic kidney disease (CKD). EPO therapy is expected to improve anemia and quality of life of patients. This analytic observational study was conducted in a cross-sectional design. It aimed to identify the difference in red blood cell profiles, namely hemoglobin (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC), and quality of life of CKD patients on EPO and non-EPO therapy at PKU Muhammadiyah Hospital in Yogyakarta. The inclusion criteria were PGK ICD N18.9 outpatients who received hemodialysis therapy at this hospital and were literate, able to understand the questionnaire, and willing to be a respondent. The results showed that there was no significant difference (p>0,05) between the red blood cells (Hb, MCV, MCH, MCHC) of the EPO and non-EPO therapy groups. The correlation between the EPO and the quality of life of patients in all of the KDQOL domains was p> 0.05. Aside from the insignificant difference between the EPO and non-EPO therapy groups, the research concluded that there was no correlation between either the EPO or the non-EPO therapy with the quality of life of hemodialysis patients