Two new eudesmanolides from Sphaeranthus indicus (Linn)

379-381Two new eudesmanolides have been isolated from the aerial part of Sphaeranthus indicus and their structures have been established as 11α,13-dihydro-3α,7α-dihydroxyeudesm-4-en 6α, 12-olide 1, 4-en-6β,7α-eudesmanolide 3, on the basis of spectral data and comparison of spectral data with those of reported data of compounds 2, 4 and 5

<span style="font-size:14.0pt;line-height: 115%;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; color:black;mso-ansi-language:EN-IN;mso-fareast-language:EN-IN;mso-bidi-language: HI" lang="EN-IN">A new eudesmanolide from <i>Sphaeranthus indicus. </i>(Linn).</span>

217-218A new eudesmanolide has been isolated from the aerial part of Sphaeranthus indicus. The structure and stereochemistry of compound 1 has been established by detailed spectral analysis and comparison of compound 1 with 11α , 13-dihydro-3α, 7α-dihydroxyfrullanolide 2 and 2α-hydroxycostic acid 3

Efficient total synthesis of naturally occurring anti-TMV compound gramniphenol G

<p>An efficient synthesis of Gramniphenol G identified as 2-(4′-Methoxyphenyl)-7,7-dimethyl-7H-furo[3,2-g]chromene and originally isolated from the plant <i>Arundina gramnifolia</i> belonging to orchidaceae family was accomplished starting from resorcinol. The key step involves the oxidative cyclization of o-vinyl phenol to provide benzofuran moiety.</p

<i>In vitro</i> and <i>ex vivo</i> antitubercular activity of diarylheptanoids from the rhizomes of <i>Alpinia officinarum</i> Hance

<p>Phytochemical investigation of methanol extract of the rhizomes of <i>Alpinia officinarum</i> Hance afforded four known diarylheptanoids 1,7-diphenylhept-4-en-3-one (<b>1</b>), 5-hydroxy-1,7-diphenyl-3-heptanone (<b>2</b>), 5-hydroxy-7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl-3-heptanone (<b>3</b>), and 7-(4″-hydroxy-3″-methoxyphenyl)-1-phenyl heptan-3-one (<b>4</b>).The acetate derivative of (<b>4</b>), 7-(4″-actetate-3″-methoxy phenyl)-1-phenyl heptan-3-one (<b>5</b>), was prepared. These diarylheptanoids exhibited promising <i>in vitro</i> and <i>ex vivo</i> antitubercular activity for the first time against dormant <i>Mycobacterium tuberculosis</i> H37Ra with the IC₅₀ values between 0.34<b>–</b>47.69 and 0.13–22.91 μM, respectively. All compounds showed comparable activity against <i>Mycobacterium bovis</i> BCG (dormant phage) and did not show any activity against two gram + ve and two gram –ve bacterial strains. These compounds were also weakly cytotoxic up to 300 μM against three human cancer cell lines THP-1, Panc-1 and A549.</p