MN2006-17031 MEASUREMENT OF MECHANICAL STRENGTH OF NANO COMPOSITE FABRICATED BY NANO COMPOSITE DEPOSITION SYSTEM (NCDS)

ABSTRACT The rapid prototyping (RP) technology has been advanced for various applications such as verification of design, functional test. Recently, researchers have studied various materials to fabricate functional RP parts. In this research, a nano composite deposition system (NCDS), which can fabricate various nano composites using polymer resins with various nano particles, was introduced. The NCDS is a hybrid system in which material removal process by mechanical micro machining and/or the deposition process is combined. To predict the mechanical behavior of nano composite part made by NCDS, it is critical to understand the mechanical properties of the NCDS material. The NCDS process was characterizes by process parameters such as raster orientation, bead width, weight percent, and curing condition. Tensile strengths and compressive strengths of fabricated specimens with various raster orientation were measured, and various sample parts made of nano composites were fabricated using NCDS. INTRODUCTION The Rapid Prototyping technology has been advanced in product development cycle for more than 20 years. Relatively new approaches of RP cover micro scale devices such as micro-stereo lithography and various materials including ceramic and composite materials. Another promising area of RP application is bio and medical fields where simulation of operation by RP model is performed, and artificial bone made by RP is implanted into human body However, many RP machines still have the stair-step effect resulting in poor surface quality, time consuming post-process and limitation of applications for various materials. In this research, a nano composite deposition system (NCDS) was developed to fabricate three dimensional nano composite parts. The NCDS uses polymer resins as matrix and various nano particles to form composite materials, an

Direct numerical simulation of a 30R long turbulent pipe flow at Re=3008

A direct numerical simulation of a turbulent pipe flow at a high Reynolds number of Re-tau = 3008 over a long axial domain length (30R) was performed. The stream-wise mean velocity followed the power law in the overlap region (y(+) = 90-300; y/R = 0.03-0.1) based on the power law indicator function. The scale separation of the Reynolds shear stresses into two components of small-and large-scale motions (LSMs) revealed that the LSMs in the outer region played an important role in constructing the constant-stress layer and the mean velocity. In the pre-multiplied energy spectra of the streamwise velocity fluctuations, the bimodal distribution was observed at both short and long wavelengths. The k(x)(-1) region associated with the attached eddies appeared in lambda(x)/R = 2-5 and lambda(x)/y = 18-160 at y(+) = 90-300, where the power law was established in the same region. The k(z)(-1) region also appeared in lambda(z)/R = 0.3-0.6 at y(+) = 3 and 150. Linear growth of small-scale energy to large-scale energy induced the k(x)(-1) region at high Reynolds numbers, resulting in a large population of the LSMs. This result supported the origin of very-large-scale motions in the pseudo-streamwise alignment of the LSMs. In the pre-multiplied energy spectra of the Reynolds shear stress, the bimodal distribution was observed without the k(x)(-1) region.open

Epitaxial Growth of a Single-Crystal Hybridized Boron Nitride and Graphene layer on a Wide-Band Gap Semiconductor

Vertical and lateral heterogeneous structures of two-dimensional (2D) materials have paved the way for pioneering studies on the physics and applications of 2D materials. A hybridized hexagonal boron nitride (h-BN) and graphene lateral structure, a heterogeneous 2D structure, has been fabricated on single-crystal metals or metal foils by chemical vapor deposition (CVD). However, once fabricated on metals, the h-BN/graphene lateral structures require an additional transfer process for device applications, as reported for CVD graphene grown on metal foils. Here, we demonstrate that a single-crystal h-BN/graphene lateral structure can be epitaxially grown on a wide-gap semiconductor, SiC(0001). First, a single-crystal h-BN layer with the same orientation as bulk SiC was grown on a Si-terminated SiC substrate at 850 oC using borazine molecules. Second, when heated above 1150 oC in vacuum, the h-BN layer was partially removed and, subsequently, replaced with graphene domains. Interestingly, these graphene domains possess the same orientation as the h-BN layer, resulting in a single-crystal h-BN/graphene lateral structure on a whole sample area. For temperatures above 1600 oC, the single-crystal h-BN layer was completely replaced by the single-crystal graphene layer. The crystalline structure, electronic band structure, and atomic structure of the h-BN/graphene lateral structure were studied by using low energy electron diffraction, angle-resolved photoemission spectroscopy, and scanning tunneling microscopy, respectively. The h-BN/graphene lateral structure fabricated on a wide-gap semiconductor substrate can be directly applied to devices without a further transfer process, as reported for epitaxial graphene on a SiC substrate.Comment: 23 pages, 7 figure

Development of a 4D hand gripping aid using a knitted shape memory alloy and evaluation of finger-bending angles in elderly women

As the global population ages, there is an increasing demand for physical assistive devices for the elderly. This study aimed to develop and evaluate a wearable gripping aid for elderly women to assist in their handgrip ability. We developed an actuator module for the hand-gripping aid using a 4D knitted shape memory alloy and attached to a flexible nylon glove. At baseline, we measured the bending angles of the knitted shape memory alloy and the subjects fingers while gripping. The bending angles of the gripping aid demonstrated similar hand mobility to those of elderly women in real life. We also found that SMA modules attached to a glove could implement the bending angle when gripping a ball derived from the index and middle fingers of elderly women. The finding could help to develop hand products that could be worn on the hand of the elderly by realizing the bending motion of each finger. The outcomes of this study suggest the practical potential of this wearable device as an effective hand-gripping aid for the elderly, based on a novel 4D material and ergonomic design approach.This work was supported by Seoul National University Research Grant in 2021 and the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (2016R1A5A1938472)

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.

Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone formation through phosphorylation of serine 14 (S14) on Inhibitor of DNA binding 2 (Id2). This enhances Id2 protein stability by means of escape from proteasomal degradation, and steers its localization to the growth cone, where Id2 interacts with radixin that is critical for growth cone formation. Knockdown of Id2, or abrogation of Id2 phosphorylation at S14, greatly impairs axon growth and the architecture of growth cone. Intriguingly, reinstatement of Akt/Id2 signaling after injury in mouse hippocampal slices redeemed growth promoting ability, leading to obvious axon regeneration. Our results suggest that Akt/Id2 signaling is a key module for growth cone formation and axon growth, and its augmentation plays a potential role in CNS axonal regeneration

Heterologous gene expression using self-assembled supra-molecules with high affinity for HSP70 chaperone

Contrary to the results of direct expression, various human proteins (ferritin light-chain, epithermal growth factor, interleukin-2, prepro-ghrelin, deletion mutants of glutamate decarboxylase and arginine deiminase, and mini-proinsulin) were all soluble in Escherichia coli cytoplasm when expressed with the N-terminus fusion of ferritin heavy-chain (FTN-H). Through systematic investigations, we have found that a specific peptide motif within FTN-H has a high affinity to HSP70 chaperone DnaK, and that the peptide motif was composed of a hydrophobic core of three residues (Ile, Phe and Leu) and two flanking regions enriched with polar residues (Gly, Gln and Arg). It was also observed that all the recombinant proteins expressed with the fusion of FTN-H formed spherical nanoparticles with diameters of 10–15 nm, as confirmed by the transmission electron microscopy image. The protein nanoparticles are non-covalently cross-linked supra-molecules formed by the self-assembly function of FTN-H. Upon the formation of the supra-molecule, its size is likely to be limited by the assembly properties of FTN-H, thereby keeping the self-assembled particles soluble. This study reports on the dual function of FTN-H for fusion expression and solubility enhancement of heterologous proteins: (i) high-affinity interaction with DnaK and (ii) formation of self-assembled supra-molecules with limited and constant sizes, thereby avoiding the undesirable formation of insoluble macro-aggregates of heterologous proteins

Frank–van der Merwe Growth versus Volmer–Weber Growth in Successive Stacking of a Few-Layer Bi2Te3/Sb2Te3 by van der Waals Heteroepitaxy: The Critical Roles of Finite Lattice-Mismatch with Seed Substrates

1133Ysciescopu

Vascular effects of estrogen in type II diabetic postmenopausal women

AbstractOBJECTIVESWe assessed the effects of estrogen on vascular dilatory and other homeostatic functions potentially affected by nitric oxide (NO)-potentiating properties in type II diabetic postmenopausal women.BACKGROUNDThere is a higher cardiovascular risk in diabetic women than in nondiabetic women. This would suggest that women with diabetes do not have the cardioprotection associated with estrogen.METHODSWe administered placebo or conjugated equine estrogen, 0.625 mg/day for 8 weeks, to 20 type II diabetic postmenopausal women in a randomized, double-blinded, placebo-controlled, cross-over design.RESULTSCompared with placebo, estrogen tended to lower low-density lipoprotein (LDL) cholesterol levels by 15 ± 23% (p = 0.007) and increase high-density lipoprotein (HDL) cholesterol levels by 8 ± 16% (p = 0.034). Thus, the ratio of LDL to HDL cholesterol levels significantly decreased with estrogen, by 20 ± 24%, as compared with placebo (p = 0.001). Compared with placebo, estrogen tended to increase triglyceride levels by 16 ± 48% and lower glycosylated hemoglobin levels by 3 ± 13% (p = 0.295 and p = 0.199, respectively). However, estrogen did not significantly improve the percent flow-mediated dilatory response to hyperemia (17 ± 75% vs. placebo; p = 0.501). The statistical power to accept our observation was 81.5%. Compared with placebo, estrogen did not significantly change E-selectin, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, monocyte chemoattractant protein-1 or matrix metalloproteinase-9 levels. Compared with placebo, estrogen tended to decrease tissue factor antigen and increase tissue factor activity levels by 7 ± 46% and 5 ± 34%, respectively (p = 0.321 and p = 0.117, respectively) and lower plasminogen activator inhibitor-1 levels by 16 ± 31% (p = 0.043).CONCLUSIONSThe effects of estrogen on endothelial, vascular dilatory and other homeostatic functions were less apparent in type II diabetic postmenopausal women, despite the beneficial effects of estrogen on lipoprotein levels