1,776 research outputs found

    PHP17 IMPACT OF CO-PAY DIFFERENTIAL ON GENERIC PRESCRIPTIONS FILLED THROUGH 90-DAY RETAIL CHANNEL

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    Multistage remediation of heavy metal contaminated river sediments in a mining region based on particle size

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    Sediment pollution is an important environmental problem, and the remediation of heavy metal contaminated sediments is crucial to river ecosystem protection, especially in mining regions. In this work, characteristics of heavy metals (Cu, Zn, Cd, As and Hg) were investigated, including contents and fractions based on particle size (PS) in river sediments. Chemical leaching and stabilization for sediment remediation were performed, and the technology feasibility was assessed. The results indicated that the heavy metals were primarily reserved within fine sediments (PS 150 mu m), while the oxidizable fraction, reducible fraction and weak acid extractable fraction dominated the total content in fine sediments, except for that of Hg. Chemical leaching can transform most metals in sediments from large-sized particles to fine particles because the metals are absorbed by fine particles in solution rather than complexation. The stabilization suggested that cement could be an effective agent for ecological risk control for heavy metals. In field engineering, a total of 145,000 m(3) sediment was divided into various sections by PS and synchronously washed by eluting agents. Finally, clean sediments (PS > 150 mu m) were used as building material and clean backfilling; meanwhile, heavily polluted sediments (PS < 150 mu m) were buried as general industrial solid waste after stabilization treatment. Over 90% of the contaminated sediments were reused throughout multistep remediation. Furthermore, a reduction in waste and harm, along with resources, was obtained. This study provided a feasible technology for heavy metal contaminated sediment remediation. (C) 2019 Elsevier Ltd. All rights reserved

    Microwave Oscillations of a Nanomagnet Driven by a Spin-Polarized Current

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    We describe direct electrical measurements of microwave-frequency dynamics in individual nanomagnets that are driven by spin transfer from a DC spin-polarized current. We map out the dynamical stability diagram as a function of current and magnetic field, and we show that spin transfer can produce several different types of magnetic excitations, including small-angle precession, a more complicated large-angle motion, and a high-current state that generates little microwave signal. The large-angle mode can produce a significant emission of microwave energy, as large as 40 times the Johnson-noise background.Comment: 12 pages, 3 figure

    Ciliary assessment in bronchiectasis: is there a clinico-pathological correlation?

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    Ciliary ultrastructural abnormalities in Chinese patients with bronchiectasis

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    Conference Theme: Challenges to specialists in the 21st centurypublished_or_final_versio

    Studies on Anti-Hepatoma Effect of Gan-Ai-Xiao Decoction

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    Purpose: To explore the anti-hepatoma effect of Gan-Ai-Xiao Decoction (GAXD), a folk remedy.Methods: High performance liquid chromatography (HPLC) was used to identify the major chemical components of GAXD ethanol extract (EE). The cytotoxic effect of GAXD EE against HepG2 cells was measured by methyl thiazolyl tetrazolium (MTT) assay. Flow cytometry and Western blot were used to study the effect of GAXD EE on apoptosis and apoptotic proteins (Bcl-2, Bax and caspase-3) in HepG2 cells. Xenograft assay was used to evaluate the anti-hepatoma effect of GAXD EE in vivo.Results: Four components were identified in GAXD EE by HPLC. The results of MTT and flow cytometry assays indicated that GAXD EE significantly reduced HepG2 cells viability (p &lt; 0.05) and induced its apoptosis. The results of Western blot assay suggested that GAXD EE down-regulated the expression of anti-apoptotic protein (Bcl-2) and up-regulated the expression of pro-apoptotic proteins (Bax and caspase-3) in HepG2 cells. Furthermore, the results of xenograft assay showed that GAXD EE significantly inhibited the growth of HepG2 cells-induced tumor (p &lt; 0.05) without any effect on the body weight of nude mice.Conclusion: GAXD has anti-hepatoma activity, and the mechanism is associated with apoptosis.Keywords: Gan-Ai-Xiao Decoction, Anti-hepatoma, Flow Cytometry, Western Blot, Xenograft, HepG2 cells, Apoptosi

    Differential regulation of cytokine-and phorbol ester-induced activation of nuclear factor kappa B by Pseudomonas aeruginosa pyocyanin in human airway epithelial cells

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    Erythromycin alters pseudomonas aeruginosa adherence to basement membrane collagen and morphology in vitro

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    Ciliary abnormalities in idiopathic bronchiectasis

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