The Use Of Multiple Technological Media In Teaching Science From The Point Of View Of Teachers Field Study On The Teachers Of Science In The Stage Of Basic Education (The Second) In The City Of Latakia

 The aim of the research is to identify the attitudes of science teachers in the basic education stage (second cycle) towards the use of multiple technological media in teaching science, and study differences in their attitudes according to gender variables, years of teaching experience, scientific qualification and computer literacy. The research was based on a descriptive analytical method. A questionnaire was developed and distributed to a random sample of (150) teachers, of which 145 were returned complete and valid for statistical analysis with a response rate of 96.67%. The research reached a number of results, the most important of which are: *The trend of science teachers in basic education (second cycle) in the city of Lattakia towards the use of multiple technological media in teaching science is a positive trend, as they have a desire to use multiple technological media technologies in teaching science because of its positive effects on the educational process of Their point of view. *There is no difference between the average grade of science teachers in the basic stage (the second episode) in their attitudes towards the use of multiple technological media in the teaching of science according to the gender variable. *There is a statistically significant difference between the average score of science teachers in the basic education stage (the second episode) in their attitudes toward the use of the various technological media in teaching science according to the variables of the scientific qualification, the years of teaching experience and computer knowledge. Teaching, and computer literacy among teachers are gaining a positive impression of the use of multiple technological media in teaching science

Novel Quinuclidinone Derivatives Induced Apoptosis in Human Breast Cancer via Targeting P53

Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). Their anticancer activities were investigated against breast cancer cells MCF-7, MDA-MB-231 breast cancer cells harboring mutant p53 and normal breast counterpart MCF-12a. Derivative 2e reduced proliferation of MCF-7 and MCD-12a while it has no effect on MDA-MB-231. Derivative 2e induced apoptosis in MCF-7 cells which is further confirmed by TUNEL assay and it reduced the percentage of cell in G2/M phase as confirmed by increased expression of cyclin B and reduced expression of cyclinD1. Derivative 2e reduced expression levels of Mdm2, Akt and ERK1/2 by and increased expression level of p53. Moreover, the apoptosis induction by 2e was also inhibited by PFT-α as evidenced by non-significant induction of apoptosis after treatment of MCF-7 cells with both derivative 2e and PFT-α. In addition, docking study reveals that derivative 2e has a binding pattern close to the pattern observed in the structure of the lead fragment 5,6-dimethoxy-2-methylbenzothiazole bound to T-p53C-Y220C. The above findings demonstrate that derivative 2e induces apoptosis in MCF-7 cells via targeting p53 which merits further development

Cooling Period Calculation of Evolutionary Power Reactor Spent Fuel for Dry Management Safety

The calculation of the evolutionary power reactor (EPR) spent fuel (SF) cooling period (CP) was performed. The CP was determined by comparing the heat load of a cask with the calculated value of EPR decay heat (DH). The EPR DH was calculated by the ORIGEN computer code based on the EPR parameters. For conservatively study, the EPR and ORIGEN parameters that lead to higher DH values were selected and safety margins were considered. The fitting tool was utilized in the calculation of CP to overcome the ORIGEN limitation. The resultant values of CP will maintain the peak cladding temperature (PCT) of SF lower than 400°C during storage, transport, and disposal. The results show that -for normal operation- the SF of EPR should stay in the pool at least 4.75 years before it is loaded to the passively cooled dry casks.Выполнен расчет периода охлаждения отработавшего ядерного топлива эволюционного(европейского) энергетического реактора (ЭЭР). Период охлаждения определялся путем сравнения термической нагрузки на контейнер с вычисленным значением остаточного энерговыделения ЭЭР. Остаточное энерговыделение ЭЭР рассчитано с применением компьютерного кода ORIGEN на основании параметров ЭЭР. Для консервативного анализа выбраны такие параметры ЭЭР и ORIGEN, которые приводят к более высоким значениям остаточного энерговыделения, а также обеспечивают необходимые запасы безопасности. При расчете периода охлаждения применялась методика корректировки для преодоления ограничения кода ORIGEN. Полученные значения периода охлаждения обеспечат поддержание максимальной температуры оболочек твэлов отработавшего топлива на уровне ниже 400 °C при хранении, транспортировке и захоронении. Результаты показали, что для нормальной эксплуатации отработавшее топливо ЭЭР должно оставаться в бассейне выдержки как минимум 4,75 года перед загрузкой в контейнеры сухого хранения с пассивным охлаждением.Розраховано період охолодження відпрацьованого ядерного палива (ВЯП) еволюційного (європейського) енергетичного реактора (ЕЕР). Період охолодження визначався порівнянням термічного навантаження на контейнер зберігання з обчисленим за допомогою комп’ютерного коду ORIGEN на основі параметрів ЕЕР значенням остаточного енерговиділення ЕЕР. Для консервативного аналізу обрано такі параметри ЕЕР та ORIGEN, що призводять до більш високих значень остаточного енерговиділення, а також забезпечують потрібні запаси безпеки. У розрахунку застосовано методику коригування для подолання обмеження коду ORIGEN. Отримані значення періоду охолодження забезпечать підтримку максимальної температури оболонок твелів ВЯП на рівні нижчому, ніж 400 °C, протягом зберігання, транспортування та захоронення. Результати показали, що ВЯП для нормальної експлуатації має залишатись у басейні витримки принаймні 4,75 року перед завантаженням у контейнери сухого зберігання з пасивним охолодженням

The Views of Secondary School Teachers Towards the Use of Strategy Inverted learning in Science Teaching Field Study in Lattakia

 The aim of the research is to identify the attitudes of secondary school teachers towards the use of the inverted learning strategy in teaching science, and to study differences in their attitudes according to gender variables, years of teaching experience, scientific qualification and computer literacy. The research was based on a descriptive method. A questionnaire was designed and distributed to a random sample of (200) teachers and schools, (187) of which were fully valid and valid for statistical analysis, with a response rate of (93.5%). The research found a number of results, the most important of which is that the attitudes of secondary school teachers towards the use of the inverted learning strategy in teaching science is positive and relatively important (79.9%). Where they have a desire to use this strategy because of their positive implications for the educational process from their point of view, where teachers emphasize that inverted learning contributes to increasing learning time by transforming the process of home learning and solving homework in the classroom, and provides a stimulating learning environment Share learners in the responsibility of learning. The results showed no statistically significant differences between the average scores of teachers in secondary education in Lattakia in their attitudes towards the use of the inverted learning strategy according to the gender variable, while there were statistically significant differences according to the variables of the academic qualification and the years of teaching experience and computer knowledge

The role of multimedia in improving the achievement level A semi-experimental study on the sixth grade students in Lattakia

The aim of the research was to construct and design a science-based multimedia education program for Grade 6 students, and to investigate the impact on learning achievement in the light of Bloom's cognitive levels (remembering, understanding, applying) and at the test level as a whole. The researcher used the semi-experimental method, where the sample was divided into two experimental groups taught by multimedia software, and a control group taught in the traditional way by the traditional school explanation. The researcher selected two samples of the sixth grade students randomly and systematically. The total number of students in each group was 25 divided by gender (23 males and 12 females) for each group, bringing the total number of students to 50. The first module of the science curriculum for the sixth grade was selected, entitled (Classification of Biology and Study of Inter-Biology Relationships in the Environment), Chapter 1 (General Characteristics and Classification of Biology) for the first semester of the academic year 2017-2018. Using the appropriate statistical methods, an impact of the multimedia learning program was found in the post-post and post-post-test trials for the experimental group

Perception of Biostatistics by Lebanese Medical Students: A Cross-Sectional Study

Background: Inadequate use of statistics in biomedical research might not only affect science but also harm human beings if applied in medical practice. Biostatistics is fundamental to improve understanding and appraising of evidence-based medicine (EBM); yet, it is still not well understood and appreciated by medical students. Therefore, early exposure of medical students and physicians-in-training to research tools including Biostatistics is of utmostimportance.Objective: The aim of this study is to determine the perception of Biostatistics by medical students at a private medical school in Beirut, Lebanon, and to identify its best implementation time in the medical curriculum.Methods: This is a cross-sectional study based on a self-administered questionnaire distributed among medical students in their pre-clerkship years (first three years of a 6-year program) who undertook Biostatistics. The assessment of perception was based on the 5-point Likert scale anchored by Strongly disagree = 1 and Strongly agree = 5 including 36 questions distributed into four domains to assess the course value, difficulty, behavioral, and expectations.Results: 186 of 269 students responded to the questionnaire, yielding a response rate of 69.14%. Around 60% of students declared that the knowledge gained from biostatistics courses is useful to their future career, and almost 70% understood the main concepts of biostatistics. 57.7% of students perceived that lack of practicing exercises might contribute to making the course more difficult. The mean score of domains was higher in females but did not significantly differ within the three academic years. Only 35.1% of the students positively perceived the importance of biostatistics modules, mostly third-year students.Conclusion: Although the majority of medical students perceived biostatistics modules negatively, they were aware of the relevance of biostatistics to their medical career and real-life health issues

Synthesis Methods in Solid-State Chemistry

The synthesis of single crystal is an area of intense activity in the materials science. The obtaining of the single crystal with sufficient dimension for X-ray diffraction depends on several factors including the chemical composition, crystal structure of the reagents, and physical parameters (temperature and pressure). In this context, this chapter is dedicated to the description of the most common synthesis methods of single crystal in the solid-state chemistry: solid-state method, hydrothermal, and slow evaporation at room temperature. Same other materials can be obtained at high pressure. There are also some physical techniques to grow single crystal, each technique is specific for specific materials

Effect of water flow rate on quantity and quality of lettuce (Lactuca sativa L.) in nutrient film technique (NFT) under hydroponics conditions

In the study of hydroponics, questions have risen concerning about ideal water flow that allow the plant to absorbing highest amount of nutrient from the nutrient solution during irrigating process. Thus, this experiment was aimed to determine the ideal water flow rate in nutrient film technique system in order to optimize the nutrients uptake with growth of lettuce. Different flow rates 10, 20 and 30 L/hour were assigned as T1, T2 and T3, respectively, with lettuce plants and the space between plants 15 cm. Generally, the growth decreased significantly with increasing in water flow rate. The analysis of lettuce hydroponics variable reveals that flow rate at 20 L/hour provides higher mean rank rather than other flow rate 10 L/hour and 30 L/hour. The findings of this research stated that if flow rate is increased to 30 L/hour plant height, number of leaves, number of outer and inner leaves, heat mass and stem mass decreases. On the whole from the analysis it is concluded that for flow rate 20 L/hour enhances the growth rate of lettuce in hydroponics hence it is stated that flow rate of 20 L/hour is good flow rate rather than 10 L/hour and 30 L/hour. Water flow in nutrient film technique is essential to be ideal through allow the plants root to absorb all elements needed form nutrient solutions in hydroponics system. And thus, water movement in the system and the rate of turnover should be designed to ensure good contact time for roots and water flow in the system

An Overview Recognizing Nephrotic Syndrome, Role Of General Physicians, Nursing And Clinical Laboratory

Nephrotic syndrome is a frequently diagnosed kidney illness in childhood, and its advancing stages can result in chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). There is a lack of longitudinal research conducted on a multi-ethnic group to identify potential risk factors that may affect the susceptibility, responsiveness to treatment, and progression of nephrotic syndrome. Temporal correlations cannot be examined using a cross-sectional study design. The clinical nursing pathway encompasses the stages of developing and applying. In a prior study, a specialized nursing team developed a nursing pathway that involved the senior level of care, the visiting physician, the clinical laboratory, and nurses.The main sources of reference were local and foreign studies, as well as the specific characteristics of the patients in the selected group. The implementation of the nursing model must be carried out strictly in accordance with the formulated plan. Subsequently, it is necessary to specify the completed section, while the incomplete section forms the main substance of the following nursing phase. The clinical nursing pathway seeks to improve patient care by promoting collaboration among different healthcare professionals and guiding them in using treatment techniques that are supported by scientific evidence